Abstract：
:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functions. Although the vasodilatory properties of CGRP are well documented, its somatosensory function regarding modulation of neuronal sensitization and of enhanced pain has received considerable attention recently. Growing evidence indicates that CGRP plays a key role in the development of peripheral sensitization and the associated enhanced pain. Calcitonin gene-related peptide is implicated in the development of neurogenic inflammation and it is upregulated in conditions of inflammatory and neuropathic pain. It is most likely that CGRP facilitates nociceptive transmission and contributes to the development and maintenance of a sensitized, hyperresponsive state not only of the primary afferent sensory neurons but also of the second-order pain transmission neurons within the central nervous system, thus contributing to central sensitization as well. The maintenance of a sensitized neuronal condition is believed to be an important factor underlying migraine. Recent successful clinical studies have shown that blocking the function of CGRP can alleviate migraine. However, the mechanisms through which CGRP may contribute to migraine are still not fully understood. We reviewed the role of CGRP in primary afferents, the dorsal root ganglion, and in the trigeminal system as well as its role in peripheral and central sensitization and its potential contribution to pain processing and to migraine.
journal_name
Painjournal_title
Painauthors
Iyengar S,Ossipov MH,Johnson KWdoi
10.1097/j.pain.0000000000000831subject
Has Abstractpub_date
2017-04-01 00:00:00pages
543-559issue
4eissn
0304-3959issn
1872-6623pii
00006396-201704000-00003journal_volume
158pub_type
杂志文章,评审相关文献
PAIN文献大全abstract：:In inflammatory neuropathy, immune activation near intact peripheral nerves induces mechanical allodynia. The identity of the peripheral immune product(s) that lead to these changes in pain behavior is unknown. The present series of studies utilized the sciatic inflammatory neuropathy (SIN) model to examine this quest...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.04.008
更新日期：2004-07-01 00:00:00
abstract：:Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000587
更新日期：2016-08-01 00:00:00
abstract：:The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90078-C
更新日期：1991-08-01 00:00:00
abstract：:The purpose of this study was to explore gender differences in pain experiences, pain control beliefs, pain coping strategies, and depressive tendency among Chinese elderly with knee osteoarthritis (OA). Participants (N=199) were drawn from a previous convenience sample of outpatients with OA in Taiwan. Results indica...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.03.014
更新日期：2007-07-01 00:00:00
abstract：:The investigation of neurotransmitter systems in placebo and nocebo effects has improved our understanding of these phenomena. Yet, most studies involve healthy participants. Because the pain modulatory system may differ in healthy participants and patients with chronic pain, it is important to investigate the evidenc...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001682
更新日期：2020-01-01 00:00:00
abstract：:Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the develo...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001497
更新日期：2019-05-01 00:00:00
abstract：:In rats anesthetized with sodium pentobarbital, we quantitatively analyzed descending modulation from the midbrain of a nociceptive flexion withdrawal reflex and responses of associated spinal neurons. We monitored the isometric force of hind limb withdrawal elicited by noxious heat stimuli (42-54 degrees C, 10 sec) o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90061-F
更新日期：1992-02-01 00:00:00
abstract：:Primary burning mouth syndrome (BMS) is defined as an "intraoral burning or dysaesthetic sensation, recurring daily… more than 3 months, without clinically evident causative lesions" (IHS 2013). In addition to pain, taste alterations are frequent (dysgeusia, xerostomia). Although lacking clinical signs of neuropathy, ...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000001090
更新日期：2018-03-01 00:00:00
abstract：:The failure to translate research evidence into day-to-day clinical practices is identified as a significant reason for suboptimal quality care across the health system, including procedural pain management in children. Clinical practice guidelines (CPGs) have been developed to assist in this process by synthesizing a...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000000090
更新日期：2015-04-01 00:00:00
abstract：:The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000000401
更新日期：2016-02-01 00:00:00
abstract：:Numerous animal studies suggest that acute and chronic exposure to opioids can be associated with the development of hyperalgesia, i.e. an increased sensitivity to noxious stimuli. Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids. A pivotal role in the gene...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(03)00276-8
更新日期：2003-11-01 00:00:00
abstract：:Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000650
更新日期：2016-11-01 00:00:00
abstract：:Medical case management has improved in the past few decades, changing the dynamic interaction between depression and prevalent medical diseases. It is relevant to describe the comorbidity between depression and medical diseases to further improve the effectiveness of case management. We analyzed the data of adults ag...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000826
更新日期：2017-04-01 00:00:00
abstract：:Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90046-0
更新日期：1984-04-01 00:00:00
abstract：:The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined. Buspirone produced dose- and time-dependent analgesia in all nociceptive tests, with greatest effects against chemical and mechanical pain. Buspirone was less po...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90181-4
更新日期：1989-10-01 00:00:00
abstract：:In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pai...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/0304-3959(87)90016-9
更新日期：1987-09-01 00:00:00
abstract：:We investigated the efficacy of local intraplantar (i.pl.) injection of peptide and non-peptide mu-, delta- and kappa-opioid receptor agonists in rat models of inflammatory and neuropathic pain. Locally applied agonists dose-dependently reduced formalin-induced flinching of the inflamed paw and induced antiallodynic a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.12.006
更新日期：2009-02-01 00:00:00
abstract：:The characteristics and impact of pain were evaluated in a prospective cross-sectional survey of 438 ambulatory AIDS patients recruited from health care facilities in New York City. More than 60% of the patients reported 'frequent or persistent pain' during the 2 wks preceding the study. Patients with pain reported an...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(96)03215-0
更新日期：1996-12-01 00:00:00
abstract：:(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91121-X
更新日期：1990-03-01 00:00:00
abstract：:The cybernetic model of analgesia is a simple servo-loop: altered sensory input--complaints--medication--temporary restoration of acceptable processing of the sensory input--return of altered sensations. Under ordinary clinical circumstances the functioning of this mechanism is masked by "noise" generated by the inter...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(79)90129-5
更新日期：1979-04-01 00:00:00
abstract：:We aimed to investigate whether small-fibre pathology, a common skin biopsy finding in patients with fibromyalgia, implies clinically important abnormalities of somatosensory system function and verify whether it is associated with voltage-gated sodium channel variants. In 57 consecutively enrolled patients with fibro...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001920
更新日期：2020-10-01 00:00:00
abstract：:Many treatments used for women with vulvodynia are based solely upon expert opinion. This randomized trial aimed to test the relative efficacy of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) in women with vulvodynia. Of the 50 participants, 42 (84%) completed 10-week treatments and 47 (94%) co...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2008.09.031
更新日期：2009-01-01 00:00:00
abstract：:As part of a comprehensive study of the natural history of herpes zoster (HZ), 57 of 94 subjects in a cohort at elevated risk for post-herpetic neuralgia (PHN) consented to collection of 3-mm skin punch biopsies from affected, mirror-image, and distant control skin at baseline and followup visits. As cutaneous innerva...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.04.002
更新日期：2010-07-01 00:00:00
abstract：:Intrathecal administration of serotonin type 2 (5-HT(2)) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antial...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2003.12.019
更新日期：2004-03-01 00:00:00
abstract：:Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the ability of the fun...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00270-1
更新日期：2002-10-01 00:00:00
abstract：:Managing acute procedural pain effectively in preterm infants in the neonatal intensive care unit remains a significant problem. The objectives of this study were to evaluate the efficacy of breastfeeding for reducing pain and to determine if breastfeeding skills were altered after this treatment. Fifty-seven infants ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2011.07.022
更新日期：2011-11-01 00:00:00
abstract：:The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(99)00233-x
更新日期：2000-03-01 00:00:00
abstract：:Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(99)00284-5
更新日期：2000-04-01 00:00:00
abstract：:Musculoskeletal trauma and pain can sensitize central pain mechanisms, but whether these normalize on recovery is unknown. This study compared the extent of pain referral in individuals recovered from a musculoskeletal trauma and healthy controls. Twenty pain-free participants recovered from a shoulder fracture and 20...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000001234
更新日期：2018-10-01 00:00:00
abstract：:Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2014.01.008
更新日期：2014-04-01 00:00:00
