The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine.

Abstract:

:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functions. Although the vasodilatory properties of CGRP are well documented, its somatosensory function regarding modulation of neuronal sensitization and of enhanced pain has received considerable attention recently. Growing evidence indicates that CGRP plays a key role in the development of peripheral sensitization and the associated enhanced pain. Calcitonin gene-related peptide is implicated in the development of neurogenic inflammation and it is upregulated in conditions of inflammatory and neuropathic pain. It is most likely that CGRP facilitates nociceptive transmission and contributes to the development and maintenance of a sensitized, hyperresponsive state not only of the primary afferent sensory neurons but also of the second-order pain transmission neurons within the central nervous system, thus contributing to central sensitization as well. The maintenance of a sensitized neuronal condition is believed to be an important factor underlying migraine. Recent successful clinical studies have shown that blocking the function of CGRP can alleviate migraine. However, the mechanisms through which CGRP may contribute to migraine are still not fully understood. We reviewed the role of CGRP in primary afferents, the dorsal root ganglion, and in the trigeminal system as well as its role in peripheral and central sensitization and its potential contribution to pain processing and to migraine.

journal_name

Pain

journal_title

Pain

authors

Iyengar S,Ossipov MH,Johnson KW

doi

10.1097/j.pain.0000000000000831

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

543-559

issue

4

eissn

0304-3959

issn

1872-6623

pii

00006396-201704000-00003

journal_volume

158

pub_type

杂志文章,评审

相关文献

PAIN文献大全
  • Preliminary validation of a self-efficacy scale for child functioning despite chronic pain (child and parent versions).

    abstract::Despite frequent targeting of health beliefs in pediatric chronic pain treatment interventions, there are currently no reliable and valid self-efficacy measures for children with chronic pain and their parents. The current study examined the psychometric properties of parent and child versions of a self-efficacy measu...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2006.04.026

    authors: Bursch B,Tsao JC,Meldrum M,Zeltzer LK

    更新日期:2006-11-01 00:00:00

  • Depression and the chronic pain experience.

    abstract::The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(91)90073-7

    authors: Haythornthwaite JA,Sieber WJ,Kerns RD

    更新日期:1991-08-01 00:00:00

  • Weight bearing of the limb as a confounding factor in assessment of mechanical allodynia in the rat.

    abstract::Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(97)00143-7

    authors: Kauppila T,Kontinen VK,Pertovaara A

    更新日期:1998-01-01 00:00:00

  • Problems of long-term spinal opioid treatment in advanced cancer patients.

    abstract::Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...

    journal_title:Pain

    pub_type: 杂志文章,评审

    doi:10.1016/S0304-3959(98)00118-3

    authors: Mercadante S

    更新日期:1999-01-01 00:00:00

  • Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study.

    abstract::A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/0304-3959(85)90010-7

    authors: Gomez-Perez FJ,Rull JA,Dies H,Rodriguez-Rivera GJ,Gonzalez-Barranco J,Lozano-Castañeda O

    更新日期:1985-12-01 00:00:00

  • A 2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury.

    abstract::Peripheral nerve injury produces a persistent neuropathic pain state characterized by spontaneous pain, allodynia and hyperalgesia. In this study, we evaluated the possible involvement of A 2ARs in the development of neuropathic pain and the expression of microglia and astrocytes in the spinal cord after sciatic nerve...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2008.07.012

    authors: Bura AS,Nadal X,Ledent C,Maldonado R,Valverde O

    更新日期:2008-11-15 00:00:00

  • An evaluation of sex differences in psychological and physiological responses to experimentally-induced pain: a path analytic description.

    abstract::A cold pressor task (CPT) was used with 203 college students (112 women and 91 men) in a study of sex differences in pain response. Physiological measures were taken before and after pain induction, and sex-differentiating personality traits were assessed with the Personal Attributes Questionnaire (PAQ). The Pain Cata...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2004.08.017

    authors: Dixon KE,Thorn BE,Ward LC

    更新日期:2004-11-01 00:00:00

  • Response to cold pressor pain and to acupuncture analgesia in Oriental and Occidental subjects.

    abstract::On a no treatment trial, a group of 24 oriental subjects rated cold pressor pain as significantly more painful and distressing than did a group of 24 occidental subjects. For half of the Orientals and half of the Occidentals, a second trial was conducted after acupuncture analgesia had been induced. The remaining 12 O...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(77)90086-0

    authors: Knox JV,Shum K,McLaughlin DM

    更新日期:1977-10-01 00:00:00

  • Effect of peripheral nerve injury on cGMP and nitric oxide synthase levels in rat dorsal root ganglia: time course and coexistence.

    abstract::Using the indirect immunofluorescence method, the distribution of cyclic GMP (cGMP) and nitric oxide synthase (NOS) was investigated in lumbar 5 dorsal root ganglia (DRGs) of untreated rats 1, 3 and 7 days following sciatic nerve section (axotomy). Untreated and axotomized (7 days) rats were also studied after perfusi...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(98)00124-9

    authors: Sten Shi TJ,Holmberg K,Xu ZD,Steinbusch H,de Vente J,Hökfelt T

    更新日期:1998-12-01 00:00:00

  • The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients.

    abstract::The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients with the NaV1.7/I848T...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001511

    authors: Meents JE,Bressan E,Sontag S,Foerster A,Hautvast P,Rösseler C,Hampl M,Schüler H,Goetzke R,Le TKC,Kleggetveit IP,Le Cann K,Kerth C,Rush AM,Rogers M,Kohl Z,Schmelz M,Wagner W,Jørum E,Namer B,Winner B,Zenke M,Lam

    更新日期:2019-06-01 00:00:00

  • Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome.

    abstract::Burning mouth syndrome is a common disorder that frequently affects women in the 5th-7th decade. It is characterized by persisting painful symptoms mainly involving the anterior two-thirds of the tongue. For several years it has been attributed to psychological causes. We investigated the innervation of the epithelium...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2005.03.028

    authors: Lauria G,Majorana A,Borgna M,Lombardi R,Penza P,Padovani A,Sapelli P

    更新日期:2005-06-01 00:00:00

  • Medically incongruent chronic back pain: physical limitations, suffering, and ineffective coping.

    abstract::Chronic low back pain (CLBP) patients with pain and symptomatology incongruent with physical pathology have been found to have a poorer outcome to medical treatment and rehabilitation, and to use health care resources excessively. To examine possible psychological and behavioral bases for this pattern, this investigat...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(88)90021-8

    authors: Reesor KA,Craig KD

    更新日期:1988-01-01 00:00:00

  • A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.

    abstract::Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(98)00120-1

    authors: Rabert DK,Koch BD,Ilnicka M,Obernolte RA,Naylor SL,Herman RC,Eglen RM,Hunter JC,Sangameswaran L

    更新日期:1998-11-01 00:00:00

  • On the relationship between nociceptive evoked potentials and intraepidermal nerve fiber density in painful sensory polyneuropathies.

    abstract::This study analyzed the relationship between the density of intraepidermal nerve fibers (IENF) and the characteristics of either nociceptive laser-evoked potentials (LEPs) or contact heat-evoked potentials (CHEPs) in patients with painful sensory polyneuropathy with the aim to determine which parameters of LEPs and CH...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2010.11.012

    authors: Casanova-Molla J,Grau-Junyent JM,Morales M,Valls-Solé J

    更新日期:2011-02-01 00:00:00

  • Spinal cord stimulation: a possible therapeutic alternative for chronic mesenteric ischaemia.

    abstract::A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(00)00266-9

    authors: Ceballos A,Cabezudo L,Bovaira M,Fenollosa P,Moro B

    更新日期:2000-07-01 00:00:00

  • Evaluating the efficacy of an attention modification program for patients with fibromyalgia: a randomized controlled trial.

    abstract::Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001746

    authors: Carleton RN,Asmundson GJG,Korol SL,LeBouthillier DM,Hozempa K,Katz JD,Vlaeyen JWS,Crombez G

    更新日期:2020-03-01 00:00:00

  • Multiple reflex sympathetic dystrophy. Which patients are at risk for developing a recurrence of reflex sympathetic dystrophy in the same or another limb.

    abstract::Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/0304-3959(95)00160-3

    authors: Veldman PHJM,Goris JAR

    更新日期:1996-03-01 00:00:00

  • Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations.

    abstract::A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...

    journal_title:Pain

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.pain.2012.03.003

    authors: Dworkin RH,Turk DC,Peirce-Sandner S,Burke LB,Farrar JT,Gilron I,Jensen MP,Katz NP,Raja SN,Rappaport BA,Rowbotham MC,Backonja MM,Baron R,Bellamy N,Bhagwagar Z,Costello A,Cowan P,Fang WC,Hertz S,Jay GW,Junor R,Ker

    更新日期:2012-06-01 00:00:00

  • Pain referral and regional deep tissue hyperalgesia in experimental human hip pain models.

    abstract::Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...

    journal_title:Pain

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.pain.2014.01.008

    authors: Izumi M,Petersen KK,Arendt-Nielsen L,Graven-Nielsen T

    更新日期:2014-04-01 00:00:00

  • Treatment outcome and compliance with therapeutic regimens: long-term follow-up of a multidisciplinary pain program.

    abstract::Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(83)90102-1

    authors: Lutz RW,Silbret M,Olshan N

    更新日期:1983-11-01 00:00:00

  • Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist.

    abstract::In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2006.01.029

    authors: Miranda-Cardenas Y,Rojas-Piloni G,Martínez-Lorenzana G,Rodríguez-Jiménez J,López-Hidalgo M,Freund-Mercier MJ,Condés-Lara M

    更新日期:2006-05-01 00:00:00

  • Parent physical and mental health contributions to interpersonal fear avoidance processes in pediatric chronic pain.

    abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001820

    authors: Birnie KA,Heathcote LC,Bhandari RP,Feinstein A,Yoon IA,Simons LE

    更新日期:2020-06-01 00:00:00

  • Receptive properties of pial afferents.

    abstract::The blood vessels and the pial surface of the brain, spinal cord and its roots are innervated by primary afferent neurones. Here, we have electrophysiologically characterized the functional properties of a subpopulation of these afferent fibres that supply the ventral roots of the cat sacral spinal cord. We have taken...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(91)90167-V

    authors: Jänig W,Koltzenburg M

    更新日期:1991-04-01 00:00:00

  • Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial.

    abstract::Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety of loxoprofen patch (LX...

    journal_title:Pain

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/j.pain.0000000000001549

    authors: Fujiki EN,Netto NA,Kraychete DC,Daher MT,Tardini R,Nakamoto A,Lopes DG

    更新日期:2019-07-01 00:00:00

  • Descending analgesia--when the spine echoes what the brain expects.

    abstract::Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2006.11.011

    authors: Goffaux P,Redmond WJ,Rainville P,Marchand S

    更新日期:2007-07-01 00:00:00

  • Pain during mammography: characteristics and relationship to demographic and medical variables.

    abstract::Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/0304-3959(96)03057-6

    authors: Kornguth PJ,Keefe FJ,Conaway MR

    更新日期:1996-08-01 00:00:00

  • Peripheral involvement of PKA and PKC in subcutaneous bee venom-induced persistent nociception, mechanical hyperalgesia, and inflammation in rats.

    abstract::The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2007.04.040

    authors: Chen HS,Lei J,He X,Qu F,Wang Y,Wen WW,You HJ,Arendt-Nielsen L

    更新日期:2008-03-01 00:00:00

  • Reflex sympathetic dystrophy following traumatic myelopathy.

    abstract::Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(84)90046-0

    authors: Wainapel SF

    更新日期:1984-04-01 00:00:00

  • Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro.

    abstract::Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(01)00318-9

    authors: Roza C,Reeh PW

    更新日期:2001-09-01 00:00:00

  • Cooperation of NMDA and tachykinin NK(1) and NK(2) receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach.

    abstract::Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signaled to the nucleus tractus solitarii (NTS) and area postrema (AP). This study examined the participation of glutamate and tachykinins in the medullary transmission process. Activation of neurons was visualized by in situ hybridization autor...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(00)00357-2

    authors: Jocic M,Schuligoi R,Schöninkle E,Pabst MA,Holzer P

    更新日期:2001-01-01 00:00:00