Abstract:
:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profiles predicted differences in clinical outcomes and central sensitization (wind-up) on average 9years later. In 843 pediatric FAP patients, cluster analysis was used to identify subgroups at initial FAP evaluation based on profiles of pain severity, gastrointestinal (GI) and non-GI symptoms, pain threat appraisal, pain coping efficacy, catastrophizing, negative affect, and activity impairment. Three profiles were identified: high pain dysfunctional, high pain adaptive, and low pain adaptive. Logistic regression analyses controlling for age and sex showed that, compared with pediatric patients with the low pain adaptive profile, those with the high pain dysfunctional profile were significantly more likely at long-term follow-up to meet criteria for pain-related functional gastrointestinal disorder (FGID) (odds ratio: 3.45, confidence interval: 1.95 to 6.11), FGID with comorbid nonabdominal chronic pain (odds ratio: 2.6, confidence interval: 1.45 to 4.66), and FGID with comorbid anxiety or depressive psychiatric disorder (odds ratio: 2.84, confidence interval: 1.35 to 6.00). Pediatric patients with the high pain adaptive profile had baseline pain severity comparable to that of the high pain dysfunctional profile, but had outcomes as favorable as the low pain adaptive profile. In laboratory pain testing at follow-up, high pain dysfunctional patients showed significantly greater thermal wind-up than low pain adaptive patients, suggesting that a subgroup of FAP patients has outcomes consistent with widespread effects of heightened central sensitization.
journal_name
Painjournal_title
Painauthors
Walker LS,Sherman AL,Bruehl S,Garber J,Smith CAdoi
10.1016/j.pain.2012.03.026subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1798-1806issue
9eissn
0304-3959issn
1872-6623pii
00006396-201209000-00009journal_volume
153pub_type
杂志文章相关文献
PAIN文献大全abstract::In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein kinase C epsilon (PKC epsilon ) agonist (psi epsilon RACK) produces prolongation of the hyperalgesia induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to as hyperalgesic priming. Since many chronic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00175-1
更新日期:2003-09-01 00:00:00
abstract::Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat model of endometriosis. Eight weeks after endometrium transplantation into the inte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001657
更新日期:2019-11-01 00:00:00
abstract::Although many patients with multiple sclerosis (MS) complain of trigeminal neuralgia (TN), its cause and mechanisms are still debatable. In a multicentre controlled study, we collected 130 patients with MS: 50 patients with TN, 30 patients with trigeminal sensory disturbances other than TN (ongoing pain, dysaesthesia,...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2008.12.026
更新日期:2009-06-01 00:00:00
abstract::High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2012.08.012
更新日期:2013-02-01 00:00:00
abstract::The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001817
更新日期:2020-06-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001886
更新日期:2020-08-01 00:00:00
abstract::The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00021-3
更新日期:1997-09-01 00:00:00
abstract::An electrophysiological study was carried out in anesthetized rats to characterize the properties of single neurons in trigeminal (V) subnucleus caudalis. Each neuron was functionally classified in terms of its cutaneous mechanoreceptive field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90010-B
更新日期:1990-06-01 00:00:00
abstract::This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(97)00126-7
更新日期:1997-12-01 00:00:00
abstract::Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90071-4
更新日期:1983-04-01 00:00:00
abstract::Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000000304
更新日期:2015-11-01 00:00:00
abstract::It is known that morphine has a negative impact on the immune responses. The potent opioids fentanyl and buprenorphine have recently become available as transdermal preparation for the treatment of chronic pain. We analyze the effect of fentanyl and buprenorphine on splenic cellular immune responses in the mouse. The ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.04.020
更新日期:2004-07-01 00:00:00
abstract::Musculoskeletal trauma and pain can sensitize central pain mechanisms, but whether these normalize on recovery is unknown. This study compared the extent of pain referral in individuals recovered from a musculoskeletal trauma and healthy controls. Twenty pain-free participants recovered from a shoulder fracture and 20...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001234
更新日期:2018-10-01 00:00:00
abstract::Poor women and women of color are disproportionately affected by HIV and this is particularly evident in sub-Saharan Africa. Even with increased access to antiretroviral therapy that makes HIV/AIDS a chronic manageable condition, little progress has been made to address the issues of pain caused by HIV disease in wome...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2007.10.009
更新日期:2007-11-01 00:00:00
abstract::To date, patients with bony metastases were only a small fraction of the samples studied, or they were entirely excluded. Patients with metastatic cancers, such as bone metastases, are more likely to report pain, compared to patients without metastatic cancer (50-74% and 15%, respectively). Their cancer pain results i...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.06.021
更新日期:2011-10-01 00:00:00
abstract::Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001146
更新日期:2018-04-01 00:00:00
abstract::The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(98)00232-2
更新日期:1999-03-01 00:00:00
abstract::Recent studies showed an enhanced general sensitivity to painful stimuli in adult migraineurs during as well as between attacks. Yet, the influence of a prolonged pain history and potential sex differences has not been studied. We used quantitative sensory testing to examine 25 children with migraine between attacks a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.12.015
更新日期:2006-07-01 00:00:00
abstract::The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1016/s0304-3959(96)03316-7
更新日期:1997-04-01 00:00:00
abstract::Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevanc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.09.038
更新日期:2014-12-01 00:00:00
abstract::A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90174-5
更新日期:1985-06-01 00:00:00
abstract::Quantitative sensory testing of heat pain sensation has become an important tool to evaluate small caliber afferent nerve function in peripheral neuropathy. In earlier studies, we found that topical application of capsaicin in humans results in the loss of epidermal nerve fibers (ENFs) with a corresponding decrease in...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(00)00444-9
更新日期:2001-04-01 00:00:00
abstract::The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91167-H
更新日期:1990-08-01 00:00:00
abstract::The existence of a pathophysiological link between tonic muscle activity and chronic muscle pain is still being debated. The purpose of this retrospective, controlled study was to evaluate the electromyographic (EMG) activity of masticatory muscles in subjects with different orofacial pain conditions. The temporal and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.03.011
更新日期:2005-07-01 00:00:00
abstract::Our objectives were to determine whether procedural pain and glucose exposure are associated with altered structural and functional brain development differently in preterm males and females, and neurodevelopment at 18-month corrected age. Fifty-one very preterm neonates (22 males; median [interquartile range] gestati...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001123
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00306-8
更新日期:2002-12-01 00:00:00
abstract::Physicians are frequently called upon to evaluate patients with chronic pain to (1) establish the etiology, (2) determine the extent of impairment and disability, and (3) prescribe treatment. In many cases, there is little agreement as to what evaluation procedures should be used or how to weight and integrate these f...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90181-9
更新日期:1988-07-01 00:00:00
abstract::Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.002
更新日期:2009-08-01 00:00:00
abstract::The effects of nitrous oxide (N2O) are thought to be mediated by several pharmacological pathways at different levels of the central nervous system. Here, we focus on excitatory glutamatergic transmission in the superficial dorsal horn of the spinal cord with respect to its importance for the nociceptive processing. T...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.03.026
更新日期:2008-01-01 00:00:00
abstract::The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00112-7
更新日期:1997-12-01 00:00:00