Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: electrophysiological and behavioral evidence.

abstract：:Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In t...

journal_title：Pain

authors： Hernández N,López Y,Vanegas H

更新日期：1989-11-01 00:00:00

abstract：:The localization of sodium channels (NaChs) change following nerve lesions and this change may contribute to the development of increased pain states. Here we examine the change in distribution of NaChs within the rat infraorbital nerve (ION) two weeks after a combined inflammatory/partial axotomy lesion that results ...

journal_title：Pain

authors： Henry MA,Freking AR,Johnson LR,Levinson SR

更新日期：2006-09-01 00:00:00

abstract：:The purpose of this study was to assess if the functional activation caused by painful stimuli could be detected with arterial spin labeling (ASL), which is a non-invasive magnetic resonance imaging (MRI) technique for measuring cerebral blood flow (CBF). Because ASL directly measures blood flow, it is well suited to ...

journal_title：Pain

authors： Owen DG,Bureau Y,Thomas AW,Prato FS,St Lawrence KS

更新日期：2008-05-01 00:00:00

abstract：:The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...

journal_title：Pain

authors： Riley JL 3rd,Wade JB,Myers CD,Sheffield D,Papas RK,Price DD

更新日期：2002-12-01 00:00:00

abstract：:This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...

journal_title：Pain

authors： Peters J,G Large R,Elkind G

更新日期：1992-07-01 00:00:00

abstract：:The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...

journal_title：Pain

authors： Paleček J,Palečková V,Dougherty PM,Willis WD

更新日期：1994-03-01 00:00:00

abstract：:Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no m...

journal_title：Pain

authors： Ling B,Authier N,Balayssac D,Eschalier A,Coudore F

更新日期：2005-12-15 00:00:00

abstract：:The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...

journal_title：Pain

authors： Leinisch E,Evers S,Kaempfe N,Kraemer C,Sostak P,Jürgens T,Straube A,May A

更新日期：2005-10-01 00:00:00

abstract：:Poor women and women of color are disproportionately affected by HIV and this is particularly evident in sub-Saharan Africa. Even with increased access to antiretroviral therapy that makes HIV/AIDS a chronic manageable condition, little progress has been made to address the issues of pain caused by HIV disease in wome...

journal_title：Pain

authors： Gray G,Berger P

更新日期：2007-11-01 00:00:00

abstract：:The aim of the present study was to determine if acupuncture stimulation inhibits sympathetic nerve activity in humans. Multiunit efferent postganglionic sympathetic activity was recorded with a tungsten microelectrode inserted in a muscle fascicle of the peroneal nerve. Mean arterial pressure, heart rate and skin blo...

journal_title：Pain

authors： Knardahl S,Elam M,Olausson B,Wallin GB

更新日期：1998-03-01 00:00:00

abstract：:Chronic neuropathic pain is associated with long-term changes at multiple levels of the neuroaxis, including in the brain, where electrical stimulation has been used to manage severe pain conditions. However, the clinical outcome of deep brain stimulation is often mixed, and the mechanisms are poorly understood. By me...

journal_title：Pain

authors： Iwata M,LeBlanc BW,Kadasi LM,Zerah ML,Cosgrove RG,Saab CY

更新日期：2011-11-01 00:00:00

abstract：:Chronic low back pain (CLBP) patients with pain and symptomatology incongruent with physical pathology have been found to have a poorer outcome to medical treatment and rehabilitation, and to use health care resources excessively. To examine possible psychological and behavioral bases for this pattern, this investigat...

journal_title：Pain

authors： Reesor KA,Craig KD

更新日期：1988-01-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00

abstract：:Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for ...

journal_title：Pain

authors： Gündel H,Valet M,Sorg C,Huber D,Zimmer C,Sprenger T,Tölle TR

更新日期：2008-07-15 00:00:00

abstract：:A secondary zone of cutaneous hyperalgesia in humans is characterized by increased pain to mechanical stimuli. In contrast, the perception of heat stimuli delivered to a secondary zone of hyperalgesia in humans often shows a paradoxical decrease in magnitude. A number of studies have shown that the responses of spinal...

journal_title：Pain

authors： Dougherty MP,Willis DW,Lenz AF

更新日期：1998-08-01 00:00:00

abstract：:Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...

journal_title：Pain

authors： Byers MR,Neuhaus SJ,Gehrig JD

更新日期：1982-07-01 00:00:00

abstract：:Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve inju...

journal_title：Pain

authors： Liljencrantz J,Björnsdotter M,Morrison I,Bergstrand S,Ceko M,Seminowicz DA,Cole J,Bushnell CM,Olausson H

更新日期：2013-02-01 00:00:00

abstract：:Forty patients with cancer pain receiving intermittent narcotics were admitted to a prospective study designed to assess the cognitive effects of narcotics. Twenty patients had undergone no change in narcotic dose or type greater than or equal to 7 days (stable dose, SD, group), and 20 patients had undergone an increa...

journal_title：Pain

authors： Bruera E,Macmillan K,Hanson J,MacDonald NR

更新日期：1989-10-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psycholo...

journal_title：Pain

authors： Cao JL,He JH,Ding HL,Zeng YM

更新日期：2005-12-05 00:00:00

abstract：:A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct ...

journal_title：Pain

authors： Shields SD,Ahn HS,Yang Y,Han C,Seal RP,Wood JN,Waxman SG,Dib-Hajj SD

更新日期：2012-10-01 00:00:00

abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...

journal_title：Pain

authors： Gomis A,Miralles A,Schmidt RF,Belmonte C

更新日期：2007-07-01 00:00:00

abstract：:Spinal synaptic plasticity is believed to drive central sensitization that underlies the persistent nature of neuropathic pain. Our recent data showed that synaptic plasticity in the dorsal horn is cell type specific: intense afferent stimulation produced long-term potentiation (LTP) in excitatory spinothalamic tract ...

journal_title：Pain

authors： Bittar A,Jun J,La JH,Wang J,Leem JW,Chung JM

更新日期：2017-11-01 00:00:00

abstract：:Musculoskeletal trauma and pain can sensitize central pain mechanisms, but whether these normalize on recovery is unknown. This study compared the extent of pain referral in individuals recovered from a musculoskeletal trauma and healthy controls. Twenty pain-free participants recovered from a shoulder fracture and 20...

journal_title：Pain

authors： Doménech-García V,Skuli Palsson T,Boudreau SA,Herrero P,Graven-Nielsen T

更新日期：2018-10-01 00:00:00

abstract：:Physicians are frequently called upon to evaluate patients with chronic pain to (1) establish the etiology, (2) determine the extent of impairment and disability, and (3) prescribe treatment. In many cases, there is little agreement as to what evaluation procedures should be used or how to weight and integrate these f...

journal_title：Pain

authors： Rudy TE,Turk DC,Brena SF

更新日期：1988-07-01 00:00:00

abstract：:Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...

journal_title：Pain

authors： Lötsch J,Dimova V,Hermens H,Zimmermann M,Geisslinger G,Oertel BG,Ultsch A

更新日期：2015-03-01 00:00:00

abstract：:The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

journal_title：Pain

authors： Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

更新日期：1995-12-01 00:00:00

abstract：ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...

journal_title：Pain

authors： Agalave NM,Rudjito R,Farinotti AB,Khoonsari PE,Sandor K,Nomura Y,Szabo-Pardi TA,Urbina CM,Palada V,Price TJ,Erlandsson Harris H,Burton MD,Kultima K,Svensson CI

更新日期：2021-02-01 00:00:00

abstract：:The experience of anger (i.e. trait anger) and anger management style (i.e. anger-in, anger-out) are related to sensitivity to acute and chronic pain stimuli, although underlying mechanisms are unknown. This study tested whether anger variables are associated with impaired endogenous opioid antinociceptive activity, a...

journal_title：Pain

authors： Bruehl S,Burns JW,Chung OY,Ward P,Johnson B

更新日期：2002-09-01 00:00:00

abstract：:Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase (COX) inhibition at both peripheral and central sites can contribute to the antihyperalgesic effects of NSAIDs, with the predominant clinical effect ...

journal_title：Pain

authors： Hodkinson DJ,Khawaja N,O'Daly O,Thacker MA,Zelaya FO,Wooldridge CL,Renton TF,Williams SCR,Howard MA

更新日期：2015-07-01 00:00:00

abstract：:Recent studies showed an enhanced general sensitivity to painful stimuli in adult migraineurs during as well as between attacks. Yet, the influence of a prolonged pain history and potential sex differences has not been studied. We used quantitative sensory testing to examine 25 children with migraine between attacks a...

journal_title：Pain

authors： Zohsel K,Hohmeister J,Oelkers-Ax R,Flor H,Hermann C

更新日期：2006-07-01 00:00:00