Abstract：
:Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain) was applied on untreated ("control") and topical capsaicin-hypersensitized ("test") skin. Z-transformed QST-parameter values obtained at the test site were compared with corresponding values published from 1236 patients with neuropathic pain using Bayesian statistics. Subjects were clustered for the resemblance of their QST pattern to neuropathic pain. Although QST parameter values from the untreated site agreed with reference values, several QST parameters acquired at the test site treated with topical capsaicin deviated from normal. These deviations resembled in 0 to 7 parameters of the QST pattern observed in patients with neuropathic pain. Higher degrees (50%-60%) of resemblance to neuropathic QST pattern were obtained in 18% of the subjects. Inclusion in the respective clusters was predictable at a cross-validated accuracy of 86.9% by a classification and regression tree comprising 3 QST parameters (mechanical pain sensitivity, wind-up ratio, and z-transformed thermal sensory limen) from the control sites. Thus, we found that topical capsaicin partly induced the desired clinical pattern of neuropathic pain in a preselectable subgroup of healthy subjects to a degree that fuels expectations that experimental pain models can be optimized toward mimicking clinical pain. The subjects, therefore, qualify for enrollment in analgesic drug studies that use highly selected cohorts to enhance predictivity for clinical analgesia.
journal_name
Painjournal_title
Painauthors
Lötsch J,Dimova V,Hermens H,Zimmermann M,Geisslinger G,Oertel BG,Ultsch Adoi
10.1097/01.j.pain.0000460328.10515.c9subject
Has Abstractpub_date
2015-03-01 00:00:00pages
405-414issue
3eissn
0304-3959issn
1872-6623pii
00006396-201503000-00010journal_volume
156pub_type
杂志文章相关文献
PAIN文献大全abstract：:Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.09.032
更新日期：2010-12-01 00:00:00
abstract：ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000002195
更新日期：2021-01-12 00:00:00
abstract：:The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90083-0
更新日期：1983-05-01 00:00:00
abstract：:Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.02.006
更新日期：2005-05-01 00:00:00
abstract：:Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is activated by cold temperatures and cooling agents, such as menthol and icilin. Compounds containing peppermint are reported to reduce symptoms of bowel hypersensitivity; however, the underlying mechanisms of action are unclear. Here we determined...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.01.027
更新日期：2011-07-01 00:00:00
abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(96)03186-7
更新日期：1996-12-01 00:00:00
abstract：:Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/01.j.pain.0000460350.30707.8d
更新日期：2015-04-01 00:00:00
abstract：:Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2006.03.019
更新日期：2006-09-01 00:00:00
abstract：:The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(97)00112-7
更新日期：1997-12-01 00:00:00
abstract：:Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)00226-1
更新日期：1998-04-01 00:00:00
abstract：:Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.02.006
更新日期：2007-11-01 00:00:00
abstract：:Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(95)00199-9
更新日期：1996-05-01 00:00:00
abstract：:Involvement of the NMDA receptor system in the transmission of nociceptive information, including the development of central sensitization and a wind-up phenomenon, has increased interest in NMDA-receptor antagonists as antinociceptive drugs. This case report describes the use of an NMDA receptor antagonist 3-(2-carbo...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90266-E
更新日期：1992-11-01 00:00:00
abstract：:The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the habituation to pain has never been evaluated. Our aim was to assess the nociceptive pathway function and the habituation to experimental pain in patients with migraine. Scalp potentials were evoked by CO(2) laser s...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(03)00137-4
更新日期：2003-09-01 00:00:00
abstract：:Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000827
更新日期：2017-04-01 00:00:00
abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)03376-9
更新日期：1997-07-01 00:00:00
abstract：:Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blin...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(95)00100-X
更新日期：1996-01-01 00:00:00
abstract：:Data from daily diaries were used to analyze pain coping processes in rheumatoid arthritis patients. For 30 consecutive days, 53 individuals described the pain coping strategies they used that day and rated the efficacy of their coping, joint pain, and positive and negative mood. Relations among variables were examine...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(96)03246-0
更新日期：1997-01-01 00:00:00
abstract：:Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(99)00097-4
更新日期：1999-11-01 00:00:00
abstract：:The efficacy of psychological treatments emphasising a self-management approach to chronic pain has been demonstrated by substantial empirical research. Nevertheless, high drop-out and relapse rates and low or unsuccessful engagement in self-management pain rehabilitation programs have prompted the suggestion that peo...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(01)00493-6
更新日期：2002-05-01 00:00:00
abstract：:Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(99)00259-6
更新日期：2000-03-01 00:00:00
abstract：:A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00266-9
更新日期：2000-07-01 00:00:00
abstract：:The aim of this study was to investigate the relationship between psychosocial work characteristics and neck and upper limb symptoms and to examine to what extent this relationship could be explained by other risk factors. Data were used from a prospective cohort study in a working population, with a follow-up period ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.12.008
更新日期：2005-03-01 00:00:00
abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(80)90049-4
更新日期：1980-12-01 00:00:00
abstract：:Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90185-6
更新日期：1994-07-01 00:00:00
abstract：:The aims of this study were threefold. Firstly, to investigate the effect of increasing threat-expectancy on attentional biases towards pain-related words. Secondly, to determine the interaction between threat-expectancy and the effectiveness of two coping strategies on pain threshold and tolerance. Thirdly, to invest...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2005.09.032
更新日期：2005-12-15 00:00:00
abstract：:The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.01.011
更新日期：2010-04-01 00:00:00
abstract：:Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90009-2
更新日期：1989-11-01 00:00:00
abstract：:Chronic pain is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance,...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.08.043
更新日期：2011-01-01 00:00:00
abstract：:Aerobic exercise has been shown to activate endogenous opioid and adrenergic systems and attenuate experimental pain in normal control subjects (NC). In contrast, fibromyalgia (FM) subjects' experimental pain ratings increase after aerobic exercise, suggestive of abnormal pain modulation. In order to determine whether...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.08.007
更新日期：2005-11-01 00:00:00
