Abstract：
:Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blind, placebo-controlled design was utilized. The sample included 258 children and adolescents aged 5-18 years who were having venipuncture or intravenous (i.v.) cannulation. After having their anxiety assessed, subjects were randomly assigned to have EMLA or placebo applied over the procedure site for 90 min. The visual analogue scale was used to assess pain caused by removal of the semi-permeable dressing and by the procedure. Other information that was collected included: duration of drug application, interval between drug removal and procedure, skin changes at bandage and drug sites and rated difficulty of the procedure. EMLA was successful 84% of the time for venipuncture and 51% of the time for i.v. cannulation. Factors which predicted success of EMLA included type of procedure, duration of drug application and anxiety. EMLA was less successful for i.v. cannulation compared to venipuncture even with duration of drug application controlled. Those who had a poor outcome were more anxious than those with a good outcome. Age of child was not a factor. Strategies for improving efficient use of EMLA were recommended.
journal_name
Painjournal_title
Painauthors
Lander J,Hodgins M,Nazarali S,McTavish J,Ouellette J,Friesen Edoi
10.1016/0304-3959(95)00100-Xsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
89-97issue
1eissn
0304-3959issn
1872-6623pii
00006396-199601000-00009journal_volume
64pub_type
临床试验,杂志文章,随机对照试验相关文献
PAIN文献大全abstract：:Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2006.03.019
更新日期：2006-09-01 00:00:00
abstract：:Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(00)00483-8
更新日期：2001-05-01 00:00:00
abstract：:Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reporte...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001877
更新日期：2020-08-01 00:00:00
abstract：:Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001746
更新日期：2020-03-01 00:00:00
abstract：:The clinical effectiveness of locally administered opioids is still under discussion; in particular, the potency of morphine in settings other than intra-articular arthroscopy has been questioned. We developed another pain model, postpartum resection of the fallopian tubes for sterilisation, in which each patient serv...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0304-3959(98)00157-2
更新日期：1999-01-01 00:00:00
abstract：:In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0304-3959(98)00062-1
更新日期：1998-06-01 00:00:00
abstract：:The molecular/genetic era has seen the discovery of a staggering number of molecules implicated in pain mechanisms [18,35,61,69,96,133,150,202,224]. This has stimulated pharmaceutical and biotechnology companies to invest billions of dollars to develop drugs that enhance or inhibit the function of many these molecules...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/j.pain.2013.05.037
更新日期：2013-12-01 00:00:00
abstract：:Unlike most classical analgesics, botulinum toxin type A (BoNT/A) does not alter acute nociceptive thresholds, and shows selectivity primarily for allodynic and hyperalgesic responses in certain pain conditions. We hypothesized that this phenomenon might be explained by characterizing the sensory neurons targeted by B...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.04.027
更新日期：2014-08-01 00:00:00
abstract：:A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(87)91074-8
更新日期：1987-08-01 00:00:00
abstract：:This study characterized the pain reported in a selected group of obstetrical patients in labor and compared the pain experienced at 2 stages of dilation, dilation of 2-5 cm and of 6-10 cm. Pain was defined as the perception of an unpleasant sensory and emotional experience with multidimensional factors that evoke beh...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90215-7
更新日期：1989-09-01 00:00:00
abstract：:The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00026-X
更新日期：2002-08-01 00:00:00
abstract：:Although pains arising from the craniofacial complex can be severe and debilitating, relatively little is known about the peripheral and central mechanisms that generate and maintain orofacial pain. To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stim...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(01)00397-9
更新日期：2002-01-01 00:00:00
abstract：:A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression. Treatment was given, in randomized order, for periods of 4 weeks, separated by 1 week wash-o...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(89)90108-5
更新日期：1989-01-01 00:00:00
abstract：:Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chron...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.02.026
更新日期：2010-05-01 00:00:00
abstract：:Pain stimulates some behaviors (e.g., withdrawal responses) but depresses many other behaviors (e.g., feeding). Pain-stimulated behaviors are widely used in preclinical research on pain and analgesia, but human and veterinary medicine often rely on measures of functional impairment and pain-depressed behavior to diagn...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.04.010
更新日期：2009-07-01 00:00:00
abstract：:Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(86)90244-7
更新日期：1986-06-01 00:00:00
abstract：:Electrophysiological evidence has been obtained suggesting the presence of reciprocal excitation between descending pathways from the nucleus raphe magnus (NRM) and adjacent reticular formation (Ret.F) and spinal cord neurones projecting to these brain stem areas. In decerebrate and decerebellate cats, 40 spinal cord ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90094-0
更新日期：1984-10-01 00:00:00
abstract：:This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.12.018
更新日期：2012-04-01 00:00:00
abstract：:When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90166-U
更新日期：1991-04-01 00:00:00
abstract：:Colonoscopy is an invaluable tool for the screening and diagnosis of many colonic diseases. For most colonoscopies, moderate sedation is used during the procedure. However, insufflation of the colon produces a nociceptive stimulus that is usually accompanied by facial grimacing/groaning while under sedation. The objec...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000446
更新日期：2016-04-01 00:00:00
abstract：:One year follow-up data are analyzed for the effects of using transcutaneous neurostimulators on patients with chronic benign pain. Those who have successful surgery for pain relief have lower pain and analgesic intake levels than those who supplement their surgery with neurostimulation. Those who do not receive surge...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(76)90044-0
更新日期：1976-03-01 00:00:00
abstract：:Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.03.024
更新日期：2012-06-01 00:00:00
abstract：:According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000116
更新日期：2015-08-01 00:00:00
abstract：:This study examined the adaptational classification stability of the multidimensional pain inventory (MPI) in two samples of female fibromyalgia syndrome patients. Retest resulted in one-third of patients being assigned to a different classification. Twenty patients had four repeated MPI assessments over a 10-month pe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.01.014
更新日期：2004-05-01 00:00:00
abstract：:Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1016/j.pain.2014.04.020
更新日期：2014-08-01 00:00:00
abstract：:Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium channel subtype...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.06.015
更新日期：2014-10-01 00:00:00
abstract：:Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90046-0
更新日期：1984-04-01 00:00:00
abstract：:We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(00)00474-7
更新日期：2001-05-01 00:00:00
abstract：:(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fl...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(81)90637-0
更新日期：1981-12-01 00:00:00
abstract：:The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.06.022
更新日期：2009-09-01 00:00:00
