Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior.

abstract：:In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein kinase C epsilon (PKC epsilon ) agonist (psi epsilon RACK) produces prolongation of the hyperalgesia induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to as hyperalgesic priming. Since many chronic...

journal_title：Pain

authors： Joseph EK,Parada CA,Levine JD

更新日期：2003-09-01 00:00:00

abstract：:This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...

journal_title：Pain

authors： Mailis A,Plapler P,Ashby P,Shoichet R,Roe S

更新日期：1997-03-01 00:00:00

abstract：:Attenuation of neuropathic manifestations in experimental animals, by lidocaine injection in the rostral ventro-medial medulla (RVM), has been traditionally attributed to selective block of a descending pain facilitatory system. However, the presence of descending fibers carrying this effect and the selective action o...

journal_title：Pain

authors： Saadé NE,Al Amin H,Tchachaghian S,Jabbur SJ,Atweh SF

更新日期：2010-04-01 00:00:00

abstract：:It is well known that acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to acupuncture analgesia is less clear. One hundred one patients who developed pain of ≥ 3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive activ...

journal_title：Pain

authors： Vase L,Baram S,Takakura N,Yajima H,Takayama M,Kaptchuk TJ,Schou S,Jensen TS,Zachariae R,Svensson P

更新日期：2013-09-01 00:00:00

abstract：:We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, do...

journal_title：Pain

authors： de Andrade DC,Mhalla A,Adam F,Texeira MJ,Bouhassira D

更新日期：2011-02-01 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be algogenic in both animals and humans. Research focus has been directed towards the P2X(3) receptor, as it is preferentially expressed on nociceptive C-fibers a...

journal_title：Pain

authors： Honore P,Kage K,Mikusa J,Watt AT,Johnston JF,Wyatt JR,Faltynek CR,Jarvis MF,Lynch K

更新日期：2002-09-01 00:00:00

abstract：:Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits ne...

journal_title：Pain

authors： Wu M,Li Z,Liang L,Ma P,Cui D,Chen P,Wu G,Song XJ

更新日期：2020-03-01 00:00:00

abstract：:Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...

journal_title：Pain

authors： Wang W,Wu SX,Wang YY,Liu XY,Li YQ

更新日期：2003-11-01 00:00:00

abstract：:Primary neuronal cell bodies, whose peripheral axons comprised the cutaneous branch of the mylohyoid nerve or innervated the mandibular molar tooth pulp or the cornea, were labeled with HRP and their cross-sectional area was analyzed. Most of their cell bodies were smaller than 1000 microns2 in cross-sectional area an...

journal_title：Pain

authors： Sugimoto T,Takemura M,Wakisaka S

更新日期：1988-03-01 00:00:00

abstract：:We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions a...

journal_title：Pain

authors： Bruera E,Fainsinger R,Moore M,Thibault R,Spoldi E,Ventafridda V

更新日期：1991-05-01 00:00:00

abstract：:The purpose of this study was to assess the hypothesis that pain and depression negatively impact the cognitive functioning of individuals with rheumatoid arthritis (RA). One hundred twenty-one community-dwelling RA patients (ages 34-84) completed a battery of cognitive tasks and multiple measures of pain and depressi...

journal_title：Pain

authors： Brown SC,Glass JM,Park DC

更新日期：2002-04-01 00:00:00

abstract：:Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective ...

journal_title：Pain

authors： Bérard A,Sheehy O,Girard S,Zhao JP,Bernatsky S

更新日期：2018-05-01 00:00:00

abstract：:Laser-evoked potentials (LEPs) are acknowledged as the most reliable laboratory tool for assessing thermal and pain pathways. Electrical stimulation with a newly developed planar concentric electrode, delivering stimuli limited to the superficial skin layers, has been suggested to provide selective activation of Aδ fi...

journal_title：Pain

authors： Perchet C,Frot M,Charmarty A,Flores C,Mazza S,Magnin M,Garcia-Larrea L

更新日期：2012-06-01 00:00:00

abstract：:Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...

journal_title：Pain

authors： Igwe OJ,Li N

更新日期：1994-07-01 00:00:00

abstract：:Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...

journal_title：Pain

authors： Wainapel SF

更新日期：1984-04-01 00:00:00

abstract：:TRPV1 is expressed in a subpopulation of myelinated Aδ and unmyelinated C-fibers. TRPV1+ fibers are essential for the transmission of nociceptive thermal stimuli and for the establishment and maintenance of inflammatory hyperalgesia. We have previously shown that high-power, short-duration pulses from an infrared diod...

journal_title：Pain

authors： Mitchell K,Lebovitz EE,Keller JM,Mannes AJ,Nemenov MI,Iadarola MJ

更新日期：2014-04-01 00:00:00

abstract：:An experimental mononeuropathy was produced in rats by unilateral loose ligation of the sciatic nerve, with a contralateral sham surgery. Repeated bilateral sensory testing was performed over time to investigate any threshold differences between the loose ligature side and the contralateral control side. A prolonged r...

journal_title：Pain

authors： Kingery WS,Castellote JM,Wang EE

更新日期：1993-12-01 00:00:00

abstract：:Morphine is increasingly used in patients with chronic non-cancer pain, but a major concern associated with chronic use relates to possible cognitive side-effects. The aim of this long-term prospective study was to evaluate the cognitive impact of oral sustained release morphine in patients with non-cancer pain. A bat...

journal_title：Pain

authors： Tassain V,Attal N,Fletcher D,Brasseur L,Dégieux P,Chauvin M,Bouhassira D

更新日期：2003-07-01 00:00:00

abstract：:The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...

journal_title：Pain

authors： Lau JYF,Badaoui M,Meehan AJ,Heathcote LC,Barker ED,Rimes KA

更新日期：2020-02-01 00:00:00

abstract：:The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo and active-controlled clinical trial. The trial involved 2 periods (separated by a 2-week washout) consisting of a 1-week wash-in phase fo...

journal_title：Pain

authors： Huggins JP,Smart TS,Langman S,Taylor L,Young T

更新日期：2012-09-01 00:00:00

abstract：:Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...

journal_title：Pain

authors： Sagen J,Winker MA,Proudfit HK

更新日期：1983-07-01 00:00:00

abstract：:The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...

journal_title：Pain

authors： Schmidtko A,Del Turco D,Coste O,Ehnert C,Niederberger E,Ruth P,Deller T,Geisslinger G,Tegeder I

更新日期：2005-05-01 00:00:00

abstract：:Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on...

journal_title：Pain

authors： Salvo E,Campana WM,Scheff NN,Nguyen TH,Jeong SH,Wall I,Wu AK,Zhang S,Kim H,Bhattacharya A,Janal MN,Liu C,Albertson DG,Schmidt BL,Dolan JC,Schmidt RE,Boada MD,Ye Y

更新日期：2020-11-01 00:00:00

abstract：:The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...

journal_title：Pain

authors： Croft PR,Lewis M,Papageorgiou AC,Thomas E,Jayson MIV,Macfarlane GJ,Silman AJ

更新日期：2001-09-01 00:00:00

abstract：:Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...

journal_title：Pain

authors： Green PG,Chen X,Alvarez P,Ferrari LF,Levine JD

更新日期：2011-11-01 00:00:00

abstract：:It has been confirmed that the voltage-gated persistent sodium currents mediate the generation of subthreshold membrane potential oscillations (SMPOs) and contribute to shaping repetitive firing. Our previous study indicated that gabapentin (GBP) administration induced a dose-dependent inhibition of SMPO in chronicall...

journal_title：Pain

authors： Yang RH,Wang WT,Chen JY,Xie RG,Hu SJ

更新日期：2009-05-01 00:00:00

abstract：:In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder. Both treatments resulted in a statistically significant ...

journal_title：Pain

authors： Zitman FG,Linssen ACG,Edelbroek PM,Van Kempen GMJ

更新日期：1991-10-01 00:00:00

abstract：:Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...

journal_title：Pain

authors： Edwards RR,Fillingim RB,Ness TJ

更新日期：2003-01-01 00:00:00

abstract：:Substance P like immunoreactivity (SPLI) and total protein (TP) concentrations in plasma and saliva were measured in 80 healthy female patients divided into the following four groups: women in group 1 were not pregnant and they were awaiting tubal ligation; women in group 2 were not pregnant but they experienced acute...

journal_title：Pain

authors： Dalby PL,Ramanathan S,Rudy TE,Roy L,Amenta JS,Aber A

更新日期：1997-02-01 00:00:00

abstract：:This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Stud...

journal_title：Pain

authors： Thakral M,Shi L,Foust JB,Patel KV,Shmerling RH,Bean JF,Leveille SG

更新日期：2016-12-01 00:00:00