当前位置： SCI文献检索 > PAIN期刊下所有文献 > The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.

Abstract：

:We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. WIN55,212-2 (0.3-10 mg kg(-1)), CP-55,940 (0.03-1 mg kg(-1)) and HU-210 (0.001-0.03 mg kg(-1)) were all active in a 'tetrad' of tests consisting of tail-flick, catalepsy, rotarod and hypothermia following subcutaneous administration, with a rank order of potency in each of HU-210 > CP-55,940 > WIN55,212-2. The effects of WIN55,212-2 in each assay were blocked by the Cannabinoid1 (CB1) antagonist SR141716A. In the partial sciatic ligation model of neuropathic pain WIN55,212-2, CP-55,940 and HU-210 produced complete reversal of mechanical hyperalgesia within 3 h of subcutaneous administration with D50 values of 0.52, 0.08 and 0.005 mg kg(-1), respectively. In this model WIN55,212-2 was also effective against thermal hyperalgesia and mechanical allodynia. WIN55,212-2 produced pronounced reversal of mechanical hyperalgesia following intrathecal administration that was blocked by the CB1 antagonist SR141716A. Following intraplantar administration into the ipsilateral hindpaw, WIN55,212-2 produced up to 70% reversal of mechanical hyperalgesia, although activity was also observed at high doses following injection into the contralateral paw. The antihyperalgesic effect of WIN55,212-2 injected into the ipsilateral paw was blocked by subcutaneously administered SR141716A, but was not affected by intrathecally administered SR141716A. These data show that cannabinoids are highly potent and efficacious antihyperalgesic agents in a model of neuropathic pain. This activity is likely to be mediated via an action in both the CNS and in the periphery.

journal_name

Pain

journal_title

Pain

authors

Fox A,Kesingland A,Gentry C,McNair K,Patel S,Urban L,James I

doi

10.1016/s0304-3959(00)00474-7

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

91-100

issue

1-2

eissn

0304-3959

issn

1872-6623

pii

S0304-3959(00)00474-7

journal_volume

92

pub_type

杂志文章

相关文献

PAIN文献大全
  • The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine.

    abstract：:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...

    journal_title：Pain

    pub_type： 杂志文章,评审

    doi：10.1097/j.pain.0000000000000831

    authors： Iyengar S,Ossipov MH,Johnson KW

    更新日期：2017-04-01 00:00:00

  • Cut and thrust: antecedent surgery and trauma among patients attending a chronic pain clinic.

    abstract：:Surgery and trauma are recognised as important causes of chronic pain, although their overall contribution has not been systematically studied. This paper reports on the contribution of surgery and trauma to chronic pain among 5130 patients attending 10 outpatient clinics located throughout North Britain. Surgery cont...

    journal_title：Pain

    pub_type： 杂志文章

    doi：

    authors： Crombie IK,Davies HT,Macrae WA

    更新日期：1998-05-01 00:00:00

  • Impairment of pain inhibition in chronic tension-type headache.

    abstract：:Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2005.08.019

    authors： Pielsticker A,Haag G,Zaudig M,Lautenbacher S

    更新日期：2005-11-01 00:00:00

  • Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse.

    abstract：:Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in somatosensory processing, as exemplified by the importance of spinal dynorphin-expressing neurons for the suppression of mechanical pain and chemical itch. Although it is...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1097/j.pain.0000000000001636

    authors： Serafin EK,Chamessian A,Li J,Zhang X,McGann A,Brewer CL,Berta T,Baccei M

    更新日期：2019-10-01 00:00:00

  • Extent of sympathetic blockade after stellate ganglion block with bupivacaine.

    abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/0304-3959(89)90023-7

    authors： Hardy PAJ,Wells JCD

    更新日期：1989-02-01 00:00:00

  • Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation.

    abstract：:Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2006.04.022

    authors： Li CY,Zhang XL,Matthews EA,Li KW,Kurwa A,Boroujerdi A,Gross J,Gold MS,Dickenson AH,Feng G,Luo ZD

    更新日期：2006-11-01 00:00:00

  • The relationship between paraspinal EMG and chronic low back pain.

    abstract：:Two models of the relationship between paraspinal EMG and low back pain have been proposed. Specific predictions arising from these are listed and the literature relating to them reviewed. Recent research on patterns of EMG rather than absolute levels is also discussed. It is concluded that there is no consistent evid...

    journal_title：Pain

    pub_type： 杂志文章,评审

    doi：10.1016/0304-3959(84)90093-9

    authors： Nouwen A,Bush C

    更新日期：1984-10-01 00:00:00

  • Mixed-methods development of a new patient-reported outcome instrument for chronic low back pain: part 2-The Patient Assessment for Low Back Pain-Impacts (PAL-I).

    abstract：:We describe qualitative and quantitative development and preliminary validation of the Patient Assessment for Low Back Pain-Impacts (PAL-I), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Concept elicitation and cognitive interviews (qualitative methods) were used to identi...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1097/j.pain.0000000000001309

    authors： Bushnell DM,Blum SI,Liedgens H,Martin ML,Freynhagen R,Wallace M,Argoff C,Eerdekens M,Kok M,Patrick DL

    更新日期：2018-10-01 00:00:00

  • Catastrophizing, pain, and functional outcomes for children with chronic pain: a meta-analytic review.

    abstract：:Pediatric chronic pain is associated with numerous negative outcomes including increased physical disability, increased rates of depression and anxiety, and decreased quality of life (QOL). Pain catastrophizing-broadly conceptualized as including rumination, magnification, and helplessness cognitions surrounding one's...

    journal_title：Pain

    pub_type： 杂志文章,meta分析,评审

    doi：10.1097/j.pain.0000000000001342

    authors： Miller MM,Meints SM,Hirsh AT

    更新日期：2018-12-01 00:00:00

  • Intraoral somatosensory abnormalities in patients with atypical odontalgia--a controlled multicenter quantitative sensory testing study.

    abstract：:Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...

    journal_title：Pain

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.pain.2013.04.005

    authors： Baad-Hansen L,Pigg M,Ivanovic SE,Faris H,List T,Drangsholt M,Svensson P

    更新日期：2013-08-01 00:00:00

  • The musculoskeletal diagnosis cohort: examining pain and pain care among veterans.

    abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1097/j.pain.0000000000000567

    authors： Goulet JL,Kerns RD,Bair M,Becker WC,Brennan P,Burgess DJ,Carroll CM,Dobscha S,Driscoll MA,Fenton BT,Fraenkel L,Haskell SG,Heapy AA,Higgins DM,Hoff RA,Hwang U,Justice AC,Piette JD,Sinnott P,Wandner L,Womack JA,Br

    更新日期：2016-08-01 00:00:00

  • Psychometric properties of the Pain Attitudes Questionnaire (revised) in adult patients with chronic pain.

    abstract：:Previous evidence supports the utility of the newly developed pain attitudes questionnaire (PAQ) for assessing pain-related stoicism and cautiousness in community-dwelling pain-free adults (Yong et al., 2001). A revised questionnaire (PAQ-R) was examined in the present study to determine the generalizability of psycho...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/S0304-3959(03)00140-4

    authors： Yong HH,Bell R,Workman B,Gibson SJ

    更新日期：2003-08-01 00:00:00

  • Cutaneous pain threshold changes after sympathetic block in reflex dystrophies.

    abstract：:In a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 day...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/0304-3959(75)90100-1

    authors： Procacci P,Francini F,Zoppi M,Maresca M

    更新日期：1975-06-01 00:00:00

  • Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome.

    abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/s0304-3959(02)00344-5

    authors： Staud R,Cannon RC,Mauderli AP,Robinson ME,Price DD,Vierck CJ Jr

    更新日期：2003-03-01 00:00:00

  • Dental nerve regeneration in rats. I. Electrophysiological studies of molar sensory deficit and recovery.

    abstract：:Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/0304-3959(83)90071-4

    authors： Berger RL,Byers MR,Calkins DF

    更新日期：1983-04-01 00:00:00

  • Endocannabinoids: a unique opportunity to develop multitarget analgesics.

    abstract：:After 4 millennia of more or less documented history of cannabis use, the identification of cannabinoids, and of Δ(9)-tetrahydrocannabinol in particular, occurred only during the early 1960s, and the cloning of cannabinoid CB1 and CB2 receptors, as well as the discovery of endocannabinoids and their metabolic enzymes,...

    journal_title：Pain

    pub_type： 杂志文章,评审

    doi：10.1016/j.pain.2013.03.023

    authors： Maione S,Costa B,Di Marzo V

    更新日期：2013-12-01 00:00:00

  • Function-limiting dysesthetic pain syndrome among traumatic spinal cord injury patients: a cross-sectional study.

    abstract：:Diffuse burning dysesthetic sensations distal to the level of spinal injury are the most common and disabling painful sequelae of traumatic spinal cord injury (SCI). In a cross-sectional study of 19 SCI patients, clinical characteristics and results of 3 validated pain measurement instruments (McGill Pain Questionnair...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/0304-3959(87)90176-X

    authors： Davidoff G,Roth E,Guarracini M,Sliwa J,Yarkony G

    更新日期：1987-04-01 00:00:00

  • Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.

    abstract：:Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1097/j.pain.0000000000001886

    authors： Stine C,Coleman DL,Flohrschutz AT,Thompson AL,Mishra S,Blagg BS,Largent-Milnes TM,Lei W,Streicher JM

    更新日期：2020-08-01 00:00:00

  • Left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation reduces the development of long-term muscle pain.

    abstract：:The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence t...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1097/j.pain.0000000000001350

    authors： Seminowicz DA,de Martino E,Schabrun SM,Graven-Nielsen T

    更新日期：2018-12-01 00:00:00

  • Quantification of local and referred muscle pain in humans after sequential i.m. injections of hypertonic saline.

    abstract：:The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...

    journal_title：Pain

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0304-3959(96)03243-5

    authors： Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

    更新日期：1997-01-01 00:00:00

  • Unmyelinated and myelinated skin nerve damage in Guillain-Barré syndrome: correlation with pain and recovery.

    abstract：:We performed a prospective study in 32 patients with Guillain-Barré syndrome (GBS) or its variants to correlate intraepidermal nerve fiber density (IENFD) at the distal leg and lumbar region with pain, autonomic dysfunction, and outcome. In the acute phase, IENFD was reduced in 60% and 61.9% of patients at the distal ...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2011.10.037

    authors： Ruts L,van Doorn PA,Lombardi R,Haasdijk ED,Penza P,Tulen JHM,Hempel RJ,van den Meiracker AH,Lauria G

    更新日期：2012-02-01 00:00:00

  • Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome.

    abstract：:Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2011.06.012

    authors： Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

    更新日期：2011-12-01 00:00:00

  • Orofacial pain: just another chronic pain? Results from a population-based survey.

    abstract：:Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/S0304-3959(02)00181-1

    authors： Macfarlane TV,Blinkhorn AS,Davies RM,Ryan P,Worthington HV,Macfarlane GJ

    更新日期：2002-10-01 00:00:00

  • Lack of analgesic effect of 50 and 100 mg oral tramadol after orthopaedic surgery: a randomized, double-blind, placebo and standard active drug comparison.

    abstract：:Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now availabl...

    journal_title：Pain

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0304-3959(95)00056-X

    authors： Stubhaug A,Grimstad J,Breivik H

    更新日期：1995-07-01 00:00:00

  • Induction of long-term potentiation of C fibre-evoked spinal field potentials requires recruitment of group I, but not group II/III metabotropic glutamate receptors.

    abstract：:In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2003.08.007

    authors： Azkue JJ,Liu XG,Zimmermann M,Sandkühler J

    更新日期：2003-12-01 00:00:00

  • Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat.

    abstract：:The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/s0304-3959(97)00021-3

    authors： Khandwala H,Hodge E,Loomis CW

    更新日期：1997-09-01 00:00:00

  • Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.

    abstract：:Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2005.02.006

    authors： Liaw WJ,Stephens RL Jr,Binns BC,Chu Y,Sepkuty JP,Johns RA,Rothstein JD,Tao YX

    更新日期：2005-05-01 00:00:00

  • Tolerance to repeated microinjection of morphine into the periaqueductal gray is associated with changes in the behavior of off- and on-cells in the rostral ventromedial medulla of rats.

    abstract：:Although the administration of opioids is the most effective treatment for pain, their efficacy is limited by the development of tolerance. The midbrain periaqueductal gray matter (PAG) participates in opioid analgesia and tolerance. Microinjection of morphine into PAG produces antinociception, probably through neuron...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/s0304-3959(00)00367-5

    authors： Tortorici V,Morgan MM,Vanegas H

    更新日期：2001-01-01 00:00:00

  • Sociodemographic disparities in chronic pain, based on 12-year longitudinal data.

    abstract：:Existing estimates of sociodemographic disparities in chronic pain in the United States are based on cross-sectional data, often treat pain as a binary construct, and rarely test for nonresponse or other types of bias. This study uses 7 biennial waves of national data from the Health and Retirement Study (1998-2010; n...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1097/j.pain.0000000000000762

    authors： Grol-Prokopczyk H

    更新日期：2017-02-01 00:00:00

  • Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia.

    abstract：:The role of 5-hydroxytryptamine (5-HT)(4), 5-HT(6), and 5-HT(7) receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term secondary mechanical allodynia and hyperalgesia. Pretreatment (-10...

    journal_title：Pain

    pub_type： 杂志文章

    doi：10.1016/j.pain.2010.12.020

    authors： Godínez-Chaparro B,Barragán-Iglesias P,Castañeda-Corral G,Rocha-González HI,Granados-Soto V

    更新日期：2011-03-01 00:00:00