Transcutaneous electrical analgesia: a follow-up analysis.

abstract：:Psychologic assessment and treatment of the family of the chronic pain patient has been thought to be of benefit in the outcome of pain therapy. The present study was designed to determine the presence of psychologic symptoms in the spouses of pain patients and the relationship of distress levels between the marital p...

journal_title：Pain

authors： Shanfield SB,Heiman EM,Cope N,Jones JR

更新日期：1979-12-01 00:00:00

abstract：:Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...

journal_title：Pain

authors： Byers MR,Neuhaus SJ,Gehrig JD

更新日期：1982-07-01 00:00:00

abstract：:This study investigated the effects of a single administration of 6-(4-methoxyphenyl)-5-methyl-3-pyridinyl-4-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), a negative allosteric modulator (NAM) of metabotropic glutamate receptor 7 (mGluR7), on pain and on affective and cognitive behavior in neuropathic mice. The activity ...

journal_title：Pain

authors： Palazzo E,Romano R,Luongo L,Boccella S,De Gregorio D,Giordano ME,Rossi F,Marabese I,Scafuro MA,de Novellis V,Maione S

更新日期：2015-06-01 00:00:00

abstract：:This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...

journal_title：Pain

authors： Nicholas MK,Wilson PH,Goyen J

更新日期：1992-03-01 00:00:00

abstract：:Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precise cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test the...

journal_title：Pain

authors： Thomaidou MA,Veldhuijzen DS,Meulders A,Evers AWM

更新日期：2021-01-01 00:00:00

abstract：:Pain evoked potentials (EPs) have been used in the last two decades as means of obtaining objective measures of pain, in clinical and experimental setups. The possibility that the pain EP wave contains elements of the endogenous P300 potential rather than being a neurophysiological correlate of pain has been raised by...

journal_title：Pain

authors： Zaslansky R,Sprecher E,Tenke EC,Hemli AJ,Yarnitsky D

更新日期：1996-07-01 00:00:00

abstract：:The aims of this study were two-fold: first, to simplify the method for creating a recently described neuropathic pain model in the rat, and second, to evaluate the effects of a number of drugs with analgesic or antihyperalgesic properties, in this model. Continuous intravenous vincristine infusion (1-100 microg kg(-1...

journal_title：Pain

authors： Nozaki-Taguchi N,Chaplan SR,Higuera ES,Ajakwe RC,Yaksh TL

更新日期：2001-07-01 00:00:00

abstract：:When faced with the problem of pain one can attempt a solution aimed at relief (assimilation) or a solution aimed at acceptance (accommodation). Using this dual process model of adaptation to pain, this study compares acute and chronic pain patients on their approach to problem solving. Three hundred and sixty-four pa...

journal_title：Pain

authors： Crombez G,Eccleston C,Van Hamme G,De Vlieger P

更新日期：2008-07-31 00:00:00

abstract：:Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...

journal_title：Pain

authors： Sagen J,Wang H,Pappas GD

更新日期：1990-07-01 00:00:00

abstract：:Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of a...

journal_title：Pain

authors： Moore RA,Derry S,Wiffen PJ,Banerjee S,Karan R,Glimm E,Wiksten A,Aldington D,Eccleston C

更新日期：2018-11-01 00:00:00

abstract：:We have developed a model in which inflammation contiguous to and within a dorsal root ganglion (DRG) was generated by local application of complete Freund's adjuvant (CFA) to the L4 lumbar spinal nerve as it exits from the intervertebral foramen. The periganglionic inflammation (PGI) elicited a marked reduction in wi...

journal_title：Pain

authors： Amaya F,Samad TA,Barrett L,Broom DC,Woolf CJ

更新日期：2009-03-01 00:00:00

abstract：:The molecular/genetic era has seen the discovery of a staggering number of molecules implicated in pain mechanisms [18,35,61,69,96,133,150,202,224]. This has stimulated pharmaceutical and biotechnology companies to invest billions of dollars to develop drugs that enhance or inhibit the function of many these molecules...

journal_title：Pain

authors： Reichling DB,Green PG,Levine JD

更新日期：2013-12-01 00:00:00

abstract：:Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...

journal_title：Pain

authors： Kleggetveit IP,Namer B,Schmidt R,Helås T,Rückel M,Ørstavik K,Schmelz M,Jørum E

更新日期：2012-10-01 00:00:00

abstract：:The present study examined the role of catastrophizing in predicting levels of pain and disability in a sample of individuals who had sustained soft-tissue injuries to the neck, shoulders or back following work or motor vehicle accidents. Participants were 86 (27 men, 59 women) consecutive referrals to the Atlantic Pa...

journal_title：Pain

authors： Sullivan MJL,Stanish W,Waite H,Sullivan M,Tripp DA

更新日期：1998-09-01 00:00:00

abstract：:Using a number of complementary anatomical and molecular techniques, we studied the effects of chronic constriction injury (CCI), a model of partial nerve injury that elicits behavioral hyperalgesia, on primary sensory neurons in the rat. Dorsal root ganglia taken from animals with CCI were analyzed for alterations in...

journal_title：Pain

authors： Nahin RL,Ren K,De León M,Ruda M

更新日期：1994-07-01 00:00:00

abstract：:We report a case control study comparing patients attending a pain clinic whose symptoms were not considered medically explained (cases) with those whose symptoms were considered medically explained (controls). Principal comparisons were psychiatric morbidity, medication use, and iatrogenic factors assessed by intervi...

journal_title：Pain

authors： Kouyanou K,Pither CE,Rabe-Hesketh S,Wessely S

更新日期：1998-06-01 00:00:00

abstract：ABSTRACT:Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. The...

journal_title：Pain

authors： Doyle TM,Janes K,Chen Z,Grace PM,Esposito E,Cuzzocrea S,Largent-Milnes TM,Neumann WL,Watkins LR,Spiegel S,Vanderah TW,Salvemini D

更新日期：2020-09-01 00:00:00

abstract：:Using the indirect immunofluorescence method, the distribution of cyclic GMP (cGMP) and nitric oxide synthase (NOS) was investigated in lumbar 5 dorsal root ganglia (DRGs) of untreated rats 1, 3 and 7 days following sciatic nerve section (axotomy). Untreated and axotomized (7 days) rats were also studied after perfusi...

journal_title：Pain

authors： Sten Shi TJ,Holmberg K,Xu ZD,Steinbusch H,de Vente J,Hökfelt T

更新日期：1998-12-01 00:00:00

abstract：:A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...

journal_title：Pain

authors： Melzack R

更新日期：1987-08-01 00:00:00

abstract：:Chronic pain is currently considered a public health problem with high costs to the individual and society. To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain. The aims of this study were to estimate the prevalence of chronic pain in the adult Danish pop...

journal_title：Pain

authors： Kurita GP,Sjøgren P,Juel K,Højsted J,Ekholm O

更新日期：2012-12-01 00:00:00

abstract：:Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...

journal_title：Pain

authors： Gu Y,Li G,Chen Y,Huang LM

更新日期：2016-07-01 00:00:00

abstract：:The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....

journal_title：Pain

authors： Ohrbach R,Crow H,Kamer A

更新日期：1998-02-01 00:00:00

abstract：:Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...

journal_title：Pain

authors： Slosky LM,BassiriRad NM,Symons AM,Thompson M,Doyle T,Forte BL,Staatz WD,Bui L,Neumann WL,Mantyh PW,Salvemini D,Largent-Milnes TM,Vanderah TW

更新日期：2016-11-01 00:00:00

abstract：:Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...

journal_title：Pain

authors： Goodenough B,Thomas W,Champion GD,Perrott D,Taplin JE,von Baeyer CL,Ziegler JB

更新日期：1999-03-01 00:00:00

abstract：:Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...

journal_title：Pain

authors： Macfarlane TV,Blinkhorn AS,Davies RM,Ryan P,Worthington HV,Macfarlane GJ

更新日期：2002-10-01 00:00:00

abstract：:Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...

journal_title：Pain

authors： Urtikova N,Berson N,Van Steenwinckel J,Doly S,Truchetto J,Maroteaux L,Pohl M,Conrath M

更新日期：2012-06-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00

abstract：:To assess the efficacy of 4% topical lidocaine in spheno-palatine blocks, a randomized controlled trial was carried out on patients with chronic muscle pain syndromes. Sixty-one patients (42 with fibromyalgia (FM) and 19 with myofascial pain syndrome (MPS)) completed the trial. Outcome measures included pain intensity...

journal_title：Pain

authors： Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

更新日期：1995-07-01 00:00:00

abstract：:The cybernetic model of analgesia is a simple servo-loop: altered sensory input--complaints--medication--temporary restoration of acceptable processing of the sensory input--return of altered sensations. Under ordinary clinical circumstances the functioning of this mechanism is masked by "noise" generated by the inter...

journal_title：Pain

authors： Keeri-Szanto M

更新日期：1979-04-01 00:00:00

abstract：:The blood vessels and the pial surface of the brain, spinal cord and its roots are innervated by primary afferent neurones. Here, we have electrophysiologically characterized the functional properties of a subpopulation of these afferent fibres that supply the ventral roots of the cat sacral spinal cord. We have taken...

journal_title：Pain

authors： Jänig W,Koltzenburg M

更新日期：1991-04-01 00:00:00