Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion.

abstract：:We report a case control study comparing patients attending a pain clinic whose symptoms were not considered medically explained (cases) with those whose symptoms were considered medically explained (controls). Principal comparisons were psychiatric morbidity, medication use, and iatrogenic factors assessed by intervi...

journal_title：Pain

authors： Kouyanou K,Pither CE,Rabe-Hesketh S,Wessely S

更新日期：1998-06-01 00:00:00

abstract：:Protein kinase signal transduction pathways play critical roles in regulating nociception. Here we show that c-kit, a tyrosine kinase receptor, is expressed in lamina I and II layer of the dorsal horn. Moreover, the superficial c-kit(+) fibers originate from the dorsal root ganglion, and c-kit in lamina II inner layer...

journal_title：Pain

authors： Sun YG,Gracias NG,Drobish JK,Vasko MR,Gereau RW,Chen ZF

更新日期：2009-07-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...

journal_title：Pain

authors： Kivitz AJ,Gimbel JS,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2013-07-01 00:00:00

abstract：:The L5 spinal nerve ligation model of neuropathic pain in rats has been proposed as a model for sympathetically maintained pain (SMP) based on the effects of surgical or chemical sympathectomy on nerve injury induced behavior. In an attempt to confirm that the lesion produces an animal model of SMP, surgical sympathec...

journal_title：Pain

authors： Ringkamp M,Eschenfelder S,Grethel EJ,Häbler HJ,Meyer RA,Jänig W,Raja SN

更新日期：1999-02-01 00:00:00

abstract：:Contrary to a clinical aphorism that early head and neck cancer is painless, we show that patients who develop head and neck cancer experience significant pain at the time of initial diagnosis. We compared orofacial pain sensitivity in groups of patients with normal oral mucosa, oral precancer, and newly diagnosed ora...

journal_title：Pain

authors： Lam DK,Schmidt BL

更新日期：2011-05-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...

journal_title：Pain

authors： Bannister K,Patel R,Goncalves L,Townson L,Dickenson AH

更新日期：2015-09-01 00:00:00

abstract：:Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been u...

journal_title：Pain

authors： Wattiez AS,Castonguay WC,Gaul OJ,Waite JS,Schmidt CM,Reis AS,Rea BJ,Sowers LP,Cintrón-Pérez CJ,Vázquez-Rosa E,Pieper AA,Russo AF

更新日期：2020-10-02 00:00:00

abstract：:Humans require the ability to discriminate intensities of noxious stimuli to avoid future harm. This discrimination process seems to be biased by an individual's attention to pain and involves modulation of the relative intensity differences between stimuli (ie, Weber fraction). Here, we ask whether attention networks...

journal_title：Pain

authors： Yang SL,Wu TW,Tseng MT

更新日期：2018-02-01 00:00:00

abstract：:A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...

journal_title：Pain

authors： Melzack R

更新日期：1987-08-01 00:00:00

abstract：:Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...

journal_title：Pain

authors： Quijada-Carrera J,Valenzuela-Castaño A,Povedano-Gómez J,Fernández-Rodriguez A,Hernánz-Mediano W,Gutierrez-Rubio A,de la Iglesia-Salgado JL,García-López A

更新日期：1996-05-01 00:00:00

abstract：:The cell soma of primary afferent neurons in the dorsal root ganglion (DRG) is assigned by classical neurophysiology the role of a metabolic depot, charged with supporting the peripheral sensory ending, the conducting axon, and the central synaptic terminals. However, certain peculiarities of DRG morphology and physio...

journal_title：Pain

authors： Devor M

更新日期：1999-08-01 00:00:00

abstract：:This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...

journal_title：Pain

authors： Grond S,Zech D,Lehmann KA,Radbruch L,Breitenbach H,Hertel D

更新日期：1997-01-01 00:00:00

abstract：:Data from daily diaries were used to analyze pain coping processes in rheumatoid arthritis patients. For 30 consecutive days, 53 individuals described the pain coping strategies they used that day and rated the efficacy of their coping, joint pain, and positive and negative mood. Relations among variables were examine...

journal_title：Pain

authors： Keefe FJ,Affleck G,Lefebvre JC,Starr K,Caldwell DS,Tennen H

更新日期：1997-01-01 00:00:00

abstract：:Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no m...

journal_title：Pain

authors： Ling B,Authier N,Balayssac D,Eschalier A,Coudore F

更新日期：2005-12-15 00:00:00

abstract：:Although trigeminal neuralgia and atypical facial pain can usually be distinguished on the basis of several well-established criteria, differential diagnosis is difficult in a small number of patients. The purpose of this study was to determine whether the McGill Pain Questionnaire (MPQ) is capable of discriminating b...

journal_title：Pain

authors： Melzack R,Terrence C,Fromm G,Amsel R

更新日期：1986-12-01 00:00:00

abstract：:A double-blind placebo-controlled crossover trial was used to determine the effects of topical ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on the sensory disturbances in 20 patients with complex regional pain syndrome (CRPS). On two occasions separated by at least one week, sensory tests to light tou...

journal_title：Pain

authors： Finch PM,Knudsen L,Drummond PD

更新日期：2009-11-01 00:00:00

abstract：:The redefinition of neuropathic pain as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system," which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast...

journal_title：Pain

authors： Finnerup NB,Haroutounian S,Kamerman P,Baron R,Bennett DLH,Bouhassira D,Cruccu G,Freeman R,Hansson P,Nurmikko T,Raja SN,Rice ASC,Serra J,Smith BH,Treede RD,Jensen TS

更新日期：2016-08-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00

abstract：:Although calcitonin gene-related peptide (CGRP) has been shown to be elevated in jugular venous blood of adult migraineurs during acute migraine attacks, it remains unknown whether CGRP is increased outside of attacks in jugular or cubital venous blood. The aim of the present study was to compare interictal plasma lev...

journal_title：Pain

authors： Ashina M,Bendtsen L,Jensen R,Schifter S,Olesen J

更新日期：2000-05-01 00:00:00

abstract：:Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...

journal_title：Pain

authors： Sagen J,Wang H,Pappas GD

更新日期：1990-07-01 00:00:00

abstract：:To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...

journal_title：Pain

authors： Tsuji T,Inui K,Kojima S,Kakigi R

更新日期：2006-08-01 00:00:00

abstract：:Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-la...

journal_title：Pain

authors： Barrière DA,Hamieh AM,Magalhães R,Traoré A,Barbier J,Bonny JM,Ardid D,Busserolles J,Mériaux S,Marchand F

更新日期：2019-10-01 00:00:00

abstract：:Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly...

journal_title：Pain

authors： Zhang H,Lund DM,Ciccone HA,Staatz WD,Ibrahim MM,Largent-Milnes TM,Seltzman HH,Spigelman I,Vanderah TW

更新日期：2018-09-01 00:00:00

abstract：:Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...

journal_title：Pain

authors： Liossi C,Failo A,Schoth DE,Williams G,Howard RF

更新日期：2018-04-01 00:00:00

abstract：:Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...

journal_title：Pain

authors： Inquimbert P,Bartels K,Babaniyi OB,Barrett LB,Tegeder I,Scholz J

更新日期：2012-12-01 00:00:00

abstract：:The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...

journal_title：Pain

authors： Lyfenko A,Vlachová V,Vyklický L,Dittert I,Kress M,Reeh PW

更新日期：2002-02-01 00:00:00

abstract：:Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...

journal_title：Pain

authors： Tesarz J,Gerhardt A,Leisner S,Janke S,Treede RD,Eich W

更新日期：2015-04-01 00:00:00

abstract：:Chemical cauterization of the central cornea with silver nitrate was assessed as a superficial injury model of tissue sensitization accompanying acute inflammation. Adult male Sprague-Dawley rats were anesthetized with halothane gas, and the centers of their right corneas treated with a silver nitrate applicator stick...

journal_title：Pain

authors： Wenk NH,Honda NC

更新日期：2003-10-01 00:00:00

abstract：:Patients with chronic pain in one limb, who experienced pain reduction with transcutaneous neurostimulation, were examined for sensory perception in that limb before and during electrical analgesia. Contralateral limbs and normal subjects served as controls. Sensory stimuli were quantified, a range of stimuli were pre...

journal_title：Pain

authors： Callaghan M,Sternbach RA,Nyquist JK,Timmermans G

更新日期：1978-08-01 00:00:00

abstract：:One year follow-up data are analyzed for the effects of using transcutaneous neurostimulators on patients with chronic benign pain. Those who have successful surgery for pain relief have lower pain and analgesic intake levels than those who supplement their surgery with neurostimulation. Those who do not receive surge...

journal_title：Pain

authors： Sternbach RA,Ignelzi RJ,Deems LM,Timmermans G

更新日期：1976-03-01 00:00:00