Unexplained peculiarities of the dorsal root ganglion.

Abstract:

:The cell soma of primary afferent neurons in the dorsal root ganglion (DRG) is assigned by classical neurophysiology the role of a metabolic depot, charged with supporting the peripheral sensory ending, the conducting axon, and the central synaptic terminals. However, certain peculiarities of DRG morphology and physiology do not sit well with this being its only role. For example, why are DRG cell somata electrically excitable, why are some able to fire repetitively on sustained depolarization, and why does the DRG lack a blood-nerve barrier? Consideration of these and related questions leads to several intriguing hypotheses: (1) Electrical excitability of the soma may be required to insure the reliable propagation of impulses past the DRG T-junction and into the spinal cord. (2) Invasion of the afferent spike into the cell soma may provide an essential feedback signal necessary for the cell soma to regulate the excitability of the sensory ending. 3) The subpopulation of DRG neurons that have repetitive firing capability may be responsible for generating the background sensation that we feel as our body schema. Moreover, these neurons may be chemical sensors that provide essential information about our body's internal milieu.

journal_name

Pain

journal_title

Pain

authors

Devor M

doi

10.1016/S0304-3959(99)00135-9

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

S27-S35

eissn

0304-3959

issn

1872-6623

pii

00006396-199908001-00006

journal_volume

Suppl 6

pub_type

杂志文章,评审

相关文献

PAIN文献大全
  • Audible and ultrasonic vocalization elicited by single electrical nociceptive stimuli to the tail in the rat.

    abstract::We describe audible and ultrasonic vocalization elicited in rats by a short electrical pulse applied to the tail. Three types of vocal emissions were recorded: (1) 'peep', characterized by a repartition of energy over a wide range (0-50 kHz) of frequencies without any clear structure; (2) 'chatters', characterized by ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(95)00049-X

    authors: Jourdan D,Ardid D,Chapuy E,Eschalier A,Le Bars D

    更新日期:1995-11-01 00:00:00

  • A loose ligature-induced mononeuropathy produces hyperalgesias mediated by both the injured sciatic nerve and the adjacent saphenous nerve.

    abstract::An experimental mononeuropathy was produced in rats by unilateral loose ligation of the sciatic nerve, with a contralateral sham surgery. Repeated bilateral sensory testing was performed over time to investigate any threshold differences between the loose ligature side and the contralateral control side. A prolonged r...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(93)90004-9

    authors: Kingery WS,Castellote JM,Wang EE

    更新日期:1993-12-01 00:00:00

  • Inhibitory mechanisms of the hyper-irritability caused by picrotoxin in the rat.

    abstract::Topically applied norepinephrine, dopamine, serotonin, GABA and glycine, and systemically administered clonidine, L-DOPA (plus carbidopa) and 5-hydroxytryptophan completely suppressed the cutaneous hyper-irritability produced in the trigeminal sensory distribution by picrotoxin overlying the caudal medulla. Cholinergi...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(81)90136-6

    authors: Sakai Y,Nishijima Y,Mikuni N,Iwata N

    更新日期:1981-08-01 00:00:00

  • Interferon-gamma induced disruption of GABAergic inhibition in the spinal dorsal horn in vivo.

    abstract::The proinflammatory cytokine interferon-gamma (IFN-gamma), which can be present in elevated levels in the central nervous system during pathological conditions, may be involved in the generation of persistent pain states by inducing neuronal hyperexcitability. The aim of the present study was to examine whether loss o...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2007.02.010

    authors: Vikman KS,Duggan AW,Siddall PJ

    更新日期:2007-12-15 00:00:00

  • Benzodiazepine mediated antagonism of opioid analgesia.

    abstract::Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0304-3959(97)03332-0

    authors: Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

    更新日期:1997-05-01 00:00:00

  • Treatment outcome and compliance with therapeutic regimens: long-term follow-up of a multidisciplinary pain program.

    abstract::Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(83)90102-1

    authors: Lutz RW,Silbret M,Olshan N

    更新日期:1983-11-01 00:00:00

  • A possible neural basis for stress-induced hyperalgesia.

    abstract::Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2009.01.011

    authors: Martenson ME,Cetas JS,Heinricher MM

    更新日期:2009-04-01 00:00:00

  • Unexpected association of the "inhibitory" neuroligin 2 with excitatory PSD95 in neuropathic pain.

    abstract::In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2013.07.035

    authors: Dolique T,Favereaux A,Roca-Lapirot O,Roques V,Léger C,Landry M,Nagy F

    更新日期:2013-11-01 00:00:00

  • Cryocautery of sensitized skin areas for the relief of pain due to post-herpetic neuralgia.

    abstract::Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(80)90049-4

    authors: Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

    更新日期:1980-12-01 00:00:00

  • Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte-neuronal function in rats with L5 spinal nerve ligation model.

    abstract::Recent studies reported the translocator protein (TSPO) to play critical roles in several kinds of neurological diseases including the inflammatory and neuropathic pain. However, the precise mechanism remains unclear. This study was undertaken to explore the distribution and possible mechanism of spinal TSPO against c...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000339

    authors: Liu X,Liu H,Xu S,Tang Z,Xia W,Cheng Z,Li W,Jin Y

    更新日期:2016-01-01 00:00:00

  • Chronic effects of topical application of capsaicin to the sciatic nerve on responses of primate spinothalamic neurons.

    abstract::The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(93)90227-G

    authors: Chung JM,Paik KS,Kim JS,Nam SC,Kim KJ,Oh UT,Hasegawa T,Chung K,Willis WD

    更新日期:1993-06-01 00:00:00

  • Phantom phenomena in mastectomized patients and their relation to chronic and acute pre-mastectomy pain.

    abstract::Chronic and acute pre-mastectomy pain as well as prevalence and characteristics of phantom phenomena following mastectomy were investigated by interview in a sample of 39 women who had undergone unilateral breast amputation. Twenty of 39 participants reported phantom sensations in the breast. Nine of the participants ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2003.10.007

    authors: Rothemund Y,Grüsser SM,Liebeskind U,Schlag PM,Flor H

    更新日期:2004-01-01 00:00:00

  • Transdermal fentanyl in the long-term treatment of cancer pain: a prospective study of 50 patients with advanced cancer of the gastrointestinal tract or the head and neck region.

    abstract::This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3959(96)03254-x

    authors: Grond S,Zech D,Lehmann KA,Radbruch L,Breitenbach H,Hertel D

    更新日期:1997-01-01 00:00:00

  • The self-efficacy of family caregivers for helping cancer patients manage pain at end-of-life.

    abstract::This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(02)00448-7

    authors: Keefe FJ,Ahles TA,Porter LS,Sutton LM,McBride CM,Pope MS,McKinstry ET,Furstenberg CP,Dalton J,Baucom DH

    更新日期:2003-05-01 00:00:00

  • Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia.

    abstract::This study determined whether opiates alter vascular components of inflammation (hyperthermia, edema and plasma extravasation) in addition to the suppression of hyperalgesia. Rats were administered carrageenan into one hind paw and saline into the other hind paw, followed by i.p. injection of morphine (0.2-5.0 mg/kg) ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(90)90054-H

    authors: Joris J,Costello A,Dubner R,Hargreaves KM

    更新日期:1990-10-01 00:00:00

  • Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.

    abstract::Numerous animal studies suggest that acute and chronic exposure to opioids can be associated with the development of hyperalgesia, i.e. an increased sensitivity to noxious stimuli. Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids. A pivotal role in the gene...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0304-3959(03)00276-8

    authors: Angst MS,Koppert W,Pahl I,Clark DJ,Schmelz M

    更新日期:2003-11-01 00:00:00

  • Sex differences in the relationship of pain patient dysfunction to spouse adjustment.

    abstract::Recent studies have suggested that spouses of chronic pain patients are at risk for emotional and marital maladjustment. This study explored the role of patient and spouse gender in mediating the effects of chronic pain on the spouse's adjustment. Eight-three chronic low back pain patients and their spouses completed ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(89)90042-0

    authors: Romano JM,Turner JA,Clancy SL

    更新日期:1989-12-01 00:00:00

  • Intratrigeminal ganglionic injection of LPA causes neuropathic pain-like behavior and demyelination in rats.

    abstract::We have previously reported a novel method for producing chronic nociceptive behavior in rats following compression of the trigeminal ganglion. In the present study, we have further studied the role of demyelination in the development of prolonged nociceptive behavior in the trigeminal territory. For this purpose, lys...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2009.07.012

    authors: Ahn DK,Lee SY,Han SR,Ju JS,Yang GY,Lee MK,Youn DH,Bae YC

    更新日期:2009-11-01 00:00:00

  • TMJ disorders and myogenic facial pain: a discriminative analysis using the McGill Pain Questionnaire.

    abstract::Our aim was to assess the discriminative capacity of the McGill Pain Questionnaire (MPQ) in patients with temporomandibular joint (TMJ) disorders or with myogenous facial pain (MP). The MPQ was administered to 57 TMJ and 28 MP patients who were also asked to assess the level of pain using the Visual Analog Scale (VAS)...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(00)00461-9

    authors: Mongini F,Italiano M

    更新日期:2001-04-01 00:00:00

  • The expression of pain in infants and toddlers: developmental changes in facial action.

    abstract::Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3959(97)00034-1

    authors: Lilley CM,Craig KD,Grunau RE

    更新日期:1997-08-01 00:00:00

  • The formalin test in mice: effect of formalin concentration.

    abstract::The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(90)91167-H

    authors: Rosland JH,Tjølsen A,Mæhle B,Hole K

    更新日期:1990-08-01 00:00:00

  • Examiner expectancy effects in the measurement of pressure pain thresholds.

    abstract::The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0304-3959(97)00174-7

    authors: Ohrbach R,Crow H,Kamer A

    更新日期:1998-02-01 00:00:00

  • Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations.

    abstract::A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...

    journal_title:Pain

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.pain.2012.03.003

    authors: Dworkin RH,Turk DC,Peirce-Sandner S,Burke LB,Farrar JT,Gilron I,Jensen MP,Katz NP,Raja SN,Rappaport BA,Rowbotham MC,Backonja MM,Baron R,Bellamy N,Bhagwagar Z,Costello A,Cowan P,Fang WC,Hertz S,Jay GW,Junor R,Ker

    更新日期:2012-06-01 00:00:00

  • Afferent large fiber polyneuropathy predicts the development of postherpetic neuralgia.

    abstract::Acute zoster infection may be followed by a chronic pain syndrome, i.e., postherpetic neuralgia (PHN). Besides older age, the intensity of pain and neuronal damage within the acutely affected body region are regarded as predictors or risk factors for PHN. As an alternative approach an underlying peripheral polyneuropa...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/S0304-3959(97)00105-X

    authors: Baron R,Haendler G,Schulte H

    更新日期:1997-11-01 00:00:00

  • Independent time courses of supraspinal nociceptive activity and spinally mediated behavior during tonic pain.

    abstract::The behavioral response to acute tissue injury is usually characterized by different phases, but the brain mechanisms underlying changes in pain-related behavior over time are still poorly understood. We aimed to analyze time-dependent changes in metabolic activity levels of 49 forebrain structures in the formalin pai...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(03)00015-0

    authors: Porro CA,Cavazzuti M,Lui F,Giuliani D,Pellegrini M,Baraldi P

    更新日期:2003-07-01 00:00:00

  • Psychosocial factors associated with pain intensity, pain-related interference, and psychological functioning in persons with multiple sclerosis and pain.

    abstract::Biopsychosocial models of chronic pain that recognize psychological and environmental factors as important aspects of adjustment to pain have been proposed for understanding chronic pain and related suffering in persons with multiple sclerosis (MS), but such models have not been empirically tested. The objective of th...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2006.07.017

    authors: Osborne TL,Jensen MP,Ehde DM,Hanley MA,Kraft G

    更新日期:2007-01-01 00:00:00

  • Intrathecal prostaglandin E1 produces a long-lasting allodynic state.

    abstract::The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(95)00055-0

    authors: Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

    更新日期:1995-12-01 00:00:00

  • A possible involvement of the central endorphin system in the autoanalgesia induced by chronic administration of Freund's adjuvant solution in rats.

    abstract::Chronic pain was induced in rats by daily injections of complete Freund's adjuvant into hind paws. Daily changes of pain threshold and endorphin (ED) content and their receptors in 4 divided parts: cortex, diencephalon-mesencephalon containing striatum (D-M), pons-medulla (P-M) and spinal cord, were measured. Decrease...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(83)90131-8

    authors: Yonehara N,Kudo T,Iwatsubo K,Maeda S,Saito K,Inoki R

    更新日期:1983-09-01 00:00:00

  • Multiple faces of pain: effects of chronic pain on the brain regulation of facial expression.

    abstract::Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000587

    authors: Vachon-Presseau E,Roy M,Woo CW,Kunz M,Martel MO,Sullivan MJ,Jackson PL,Wager TD,Rainville P

    更新日期:2016-08-01 00:00:00

  • EVENDOL, a new behavioral pain scale for children ages 0 to 7 years in the emergency department: design and validation.

    abstract::Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2012.02.024

    authors: Fournier-Charrière E,Tourniaire B,Carbajal R,Cimerman P,Lassauge F,Ricard C,Reiter F,Turquin P,Lombart B,Letierce A,Falissard B

    更新日期:2012-08-01 00:00:00