Abstract:
:Contrary to a clinical aphorism that early head and neck cancer is painless, we show that patients who develop head and neck cancer experience significant pain at the time of initial diagnosis. We compared orofacial pain sensitivity in groups of patients with normal oral mucosa, oral precancer, and newly diagnosed oral cancer. The University of California San Francisco Oral Cancer Pain Questionnaire was administered to these patients at their initial visit, before being prescribed analgesics for pain and before any treatment. In contrast to those with biopsy-proven normal oral mucosa and oral precancer, only oral cancer patients reported significant levels of spontaneous pain and functional restriction from pain. Moreover, oral cancer patients experienced significantly higher function-related, rather than spontaneous, pain qualities. These findings suggest an important predictor for the transition from oral precancer to cancer may be the onset of orofacial pain that is exacerbated during function. Screening patients who have new-onset orofacial pain may lead to a diagnosis of early resectable head and neck cancer and may improve quality of life and survival for head and neck cancer patients.
journal_name
Painjournal_title
Painauthors
Lam DK,Schmidt BLdoi
10.1016/j.pain.2011.02.009subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1206-1209issue
5eissn
0304-3959issn
1872-6623pii
00006396-201105000-00036journal_volume
152pub_type
杂志文章相关文献
PAIN文献大全abstract::Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. The results of these studies may be challenged due to methodological problems. We therefore conducted a double-blind, controlled, cross-over study on the effect of acute hyperglycemia on nociceptive and n...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)90148-1
更新日期:1994-01-01 00:00:00
abstract::This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.02.030
更新日期:2011-06-01 00:00:00
abstract::The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90096-5
更新日期:1994-02-01 00:00:00
abstract::Twenty-six patients with severe pain associated with cancer were entered into a study where they were required to take morphine mixture for 7 days. Prior to this, their morphine dose had been optimised to provide the most favourable balance between pain relief and side effects. After 6 days of taking their optimised m...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)00204-R
更新日期:1995-06-01 00:00:00
abstract::In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90091-4
更新日期:1982-10-01 00:00:00
abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001857
更新日期:2020-07-01 00:00:00
abstract::In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.01.006
更新日期:2012-04-01 00:00:00
abstract::Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000000927
更新日期:2017-08-01 00:00:00
abstract::Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.011
更新日期:2012-12-01 00:00:00
abstract::Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460328.10515.c9
更新日期:2015-03-01 00:00:00
abstract::The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90152-2
更新日期:1992-05-01 00:00:00
abstract::Is a person's response to one noxious stimulus similar to his/her responses to other noxious stimuli? This long-investigated topic in pain research has provided inconclusive results. In the present study, 2 samples were studied: one using 60 healthy volunteers and the other using 29 patients with coronary artery disea...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90135-X
更新日期:1994-09-01 00:00:00
abstract::Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat. However, it is not known whether such agonists are elevated in human inflammatory pain conditions. Because TRPV1 is expressed in human ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.07.011
更新日期:2013-11-01 00:00:00
abstract::The present study is a long-term report on 69 patients undergoing unilateral percutaneous cervical cordotomy for vertebral pain due to neoplastic bone metastases. The pain was unilateral or bilateral and was characterised by a chronic and/or an incident component. Seventy-one per cent (49/69) of the patients benefitte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90832-7
更新日期:1984-06-01 00:00:00
abstract::Spasticity is a major clinical manifestation of spinal cord injury and upper motor neuron syndrome. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00255-9
更新日期:2000-03-01 00:00:00
abstract:ABSTRACT:Sociodemographic inequalities in the occurrence of low back pain (LBP) are well-studied. This study aimed to examine complex sociodemographic inequalities in the risk of LBP consultation in the population from a socioeconomical intersectional perspective. Using register data, we identified 458,852 individuals ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002081
更新日期:2020-09-16 00:00:00
abstract::Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00093-6
更新日期:1997-11-01 00:00:00
abstract::Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Long-term potentiation (LTP) in wide dynamic range (WDR) neurons in the dorsal horn has been suggested to contribute to central sensitization and the development of chronic pain. Indirect experimental evidence indicates an involvement of substance P (SP), in this respect. The aim of the present study was to monitor th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00414-6
更新日期:2002-03-01 00:00:00
abstract::Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(99)00284-5
更新日期:2000-04-01 00:00:00
abstract:ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002160
更新日期:2020-11-30 00:00:00
abstract::Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00344-5
更新日期:2003-03-01 00:00:00
abstract::Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.024
更新日期:2012-08-01 00:00:00
abstract::Percentage of pain intensity difference (PercentPID) is a recognized way of evaluating pain relief with an 11-point numerical rating scale (NRS) but is not without flaws. A new metric, the slope of relative pain intensity difference (SlopePID), which consists in dividing PercentPID by the time between 2 pain measureme...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000382
更新日期:2016-02-01 00:00:00
abstract::Behavioral studies have suggested that placebo analgesia is partly mediated by the endogenous opioid system. Expanding on these results we have shown that the opioid-receptor-rich rostral anterior cingulate cortex (rACC) is activated in both placebo and opioid analgesia. However, there are also differences between the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.03.011
更新日期:2010-07-01 00:00:00
abstract::In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90808-X
更新日期:1984-09-01 00:00:00
abstract::The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001764
更新日期:2020-04-01 00:00:00
abstract::We have constructed and validated the Elderly Pain Caring Assessment 2 (EPCA-2) an 8 items behavioural scale to rate the intensity of pain in non-verbally communicating older (age 65 years) patients (NVC-OP). It was postulated that the assessed pain had two dimensions (signs outside and during caregiving). The first v...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.03.007
更新日期:2007-12-15 00:00:00
abstract::The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered. Subjects were provided with high and low levels of information regarding t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90080-0
更新日期:1984-08-01 00:00:00
abstract::The experience of anger (i.e. trait anger) and anger management style (i.e. anger-in, anger-out) are related to sensitivity to acute and chronic pain stimuli, although underlying mechanisms are unknown. This study tested whether anger variables are associated with impaired endogenous opioid antinociceptive activity, a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(02)00104-5
更新日期:2002-09-01 00:00:00