Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.

abstract：:Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...

journal_title：Pain

authors： Ingemar F,Ahlgren H,Ahlgren MBE

更新日期：1987-12-01 00:00:00

abstract：:Intrathecal (i.t.) injection of substance P (SP) results in a behavioral syndrome characterized by caudally directed biting and scratching. The present results indicate that repeated injections of 10 ng of SP, administered at 60 sec intervals, result in the rapid development of tachyphylaxis to this SP-induced behavio...

journal_title：Pain

authors： Larson AA

更新日期：1988-03-01 00:00:00

abstract：:Electrophysiological evidence has been obtained suggesting the presence of reciprocal excitation between descending pathways from the nucleus raphe magnus (NRM) and adjacent reticular formation (Ret.F) and spinal cord neurones projecting to these brain stem areas. In decerebrate and decerebellate cats, 40 spinal cord ...

journal_title：Pain

authors： Cervero F,Wolstencroft JH

更新日期：1984-10-01 00:00:00

abstract：:Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chron...

journal_title：Pain

authors： van Laarhoven AIM,Kraaimaat FW,Wilder-Smith OH,van de Kerkhof PCM,Evers AWM

更新日期：2010-05-01 00:00:00

abstract：:Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...

journal_title：Pain

authors： Liaw WJ,Stephens RL Jr,Binns BC,Chu Y,Sepkuty JP,Johns RA,Rothstein JD,Tao YX

更新日期：2005-05-01 00:00:00

abstract：:Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...

journal_title：Pain

authors： North RB,Han M,Zahurak M,Kidd DH

更新日期：1994-04-01 00:00:00

abstract：:Migraine headache is one of the most common neurological disorders. The pathological conditions that directly initiate afferent pain signaling are poorly understood. In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology....

journal_title：Pain

authors： Yan J,Edelmayer RM,Wei X,De Felice M,Porreca F,Dussor G

更新日期：2011-01-01 00:00:00

abstract：:Increased blood pressure and sweet taste are often associated with decreased pain sensitivity. Animal research suggests that endogenous opioids are involved in both these relationships. Fifty-eight healthy young adults (36 male, 22 female) participated in two sessions receiving a placebo tablet or 50mg of naltrexone o...

journal_title：Pain

authors： Lewkowski MD,Young SN,Ghosh S,Ditto B

更新日期：2008-03-01 00:00:00

abstract：:Fear-avoidance beliefs have been identified as an important psychosocial variable in patients with chronic disability doe to low back pain. The importance of fear-avoidance beliefs for individuals with acute low back pain has not been explored. Seventy-eight subjects with work-related low back pain of less than 3 week...

journal_title：Pain

authors： Fritz JM,George SZ,Delitto A

更新日期：2001-10-01 00:00:00

abstract：:Many treatments used for women with vulvodynia are based solely upon expert opinion. This randomized trial aimed to test the relative efficacy of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) in women with vulvodynia. Of the 50 participants, 42 (84%) completed 10-week treatments and 47 (94%) co...

journal_title：Pain

authors： Masheb RM,Kerns RD,Lozano C,Minkin MJ,Richman S

更新日期：2009-01-01 00:00:00

abstract：:Although pains arising from the craniofacial complex can be severe and debilitating, relatively little is known about the peripheral and central mechanisms that generate and maintain orofacial pain. To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stim...

journal_title：Pain

authors： Sabino MA,Honore P,Rogers SD,Mach DB,Luger NM,Mantyh PW

更新日期：2002-01-01 00:00:00

abstract：:Treatment of adult rats with a single dose of nerve growth factor (NGF, 1 mg/kg, i.p.) results in a prolonged hypersensitivity to noxious thermal stimulation which becomes noticeable within 30 min of administration and lasts for several days. A significant mechanical hyperalgesia develops within 7 h following injectio...

journal_title：Pain

authors： Rueff A,Dawson AJ,Mendell LM

更新日期：1996-08-01 00:00:00

abstract：:Although both a loss of spinal inhibitory neurotransmission and the involvement of oxidative stress have been regarded as important mechanisms in the pathogenesis of pain, the relationship between these 2 mechanisms has not been studied. To determine whether reactive oxygen species (ROS) involvement in pain mechanisms...

journal_title：Pain

authors： Yowtak J,Lee KY,Kim HY,Wang J,Kim HK,Chung K,Chung JM

更新日期：2011-04-01 00:00:00

abstract：:Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...

journal_title：Pain

authors： Izumi M,Petersen KK,Arendt-Nielsen L,Graven-Nielsen T

更新日期：2014-04-01 00:00:00

abstract：:To assess the efficacy of 4% topical lidocaine in spheno-palatine blocks, a randomized controlled trial was carried out on patients with chronic muscle pain syndromes. Sixty-one patients (42 with fibromyalgia (FM) and 19 with myofascial pain syndrome (MPS)) completed the trial. Outcome measures included pain intensity...

journal_title：Pain

authors： Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

更新日期：1995-07-01 00:00:00

abstract：:Manipulative therapy is frequently used in the management of musculoskeletal pain. A frequently reported clinical feature of this treatment is the immediacy with which it appears to initiate improvement in pain and function. A randomised, double blind, placebo controlled, repeated measures design was employed to study...

journal_title：Pain

authors： Vicenzino B,Collins D,Wright A

更新日期：1996-11-01 00:00:00

abstract：:Peripheral nerve injury produces a persistent neuropathic pain state characterized by spontaneous pain, allodynia and hyperalgesia. In this study, we evaluated the possible involvement of A 2ARs in the development of neuropathic pain and the expression of microglia and astrocytes in the spinal cord after sciatic nerve...

journal_title：Pain

authors： Bura AS,Nadal X,Ledent C,Maldonado R,Valverde O

更新日期：2008-11-15 00:00:00

abstract：:The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...

journal_title：Pain

authors： Croft PR,Lewis M,Papageorgiou AC,Thomas E,Jayson MIV,Macfarlane GJ,Silman AJ

更新日期：2001-09-01 00:00:00

abstract：:Quantitative sensory testing of heat pain sensation has become an important tool to evaluate small caliber afferent nerve function in peripheral neuropathy. In earlier studies, we found that topical application of capsaicin in humans results in the loss of epidermal nerve fibers (ENFs) with a corresponding decrease in...

journal_title：Pain

authors： Khalili N,Wendelschafer-Crabb G,Kennedy WR,Simone DA

更新日期：2001-04-01 00:00:00

abstract：:Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...

journal_title：Pain

authors： Elliott K,Hynansky A,Inturrisi CE

更新日期：1994-12-01 00:00:00

abstract：:Patients with acute whiplash trauma were followed to examine if post-trauma ratings of pre-collision pain and psychological distress were associated with reduced work capability and neck pain at 12 months follow-up. The study included 740 consecutive patients (474 females, 266 males) referred from emergency department...

journal_title：Pain

authors： Carstensen TBW,Frostholm L,Oernboel E,Kongsted A,Kasch H,Jensen TS,Fink P

更新日期：2008-10-15 00:00:00

abstract：:Patients with sensory disturbances of painful and non-painful character show distinct changes in touch and/or pain sensitivity. The patterns of sensory changes were compared to those of human surrogate models of neuropathic pain to assess the underlying mechanisms. We investigated 30 consecutive in-patients with dysae...

journal_title：Pain

authors： Baumgärtner U,Magerl W,Klein T,Hopf HC,Treede RD

更新日期：2002-03-01 00:00:00

abstract：:Attenuation of neuropathic manifestations in experimental animals, by lidocaine injection in the rostral ventro-medial medulla (RVM), has been traditionally attributed to selective block of a descending pain facilitatory system. However, the presence of descending fibers carrying this effect and the selective action o...

journal_title：Pain

authors： Saadé NE,Al Amin H,Tchachaghian S,Jabbur SJ,Atweh SF

更新日期：2010-04-01 00:00:00

abstract：:Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to ...

journal_title：Pain

authors： Kauppila T,Kontinen VK,Pertovaara A

更新日期：1998-01-01 00:00:00

abstract：:The information from nociceptors is processed in the dorsal horn of the spinal cord by complex circuits involving excitatory and inhibitory interneurons. It is well documented that GluN2B and ERK1/2 phosphorylation contributes to central sensitization. Striatal-enriched protein tyrosine phosphatase (STEP) dephosphoryl...

journal_title：Pain

authors： Azkona G,Saavedra A,Aira Z,Aluja D,Xifró X,Baguley T,Alberch J,Ellman JA,Lombroso PJ,Azkue JJ,Pérez-Navarro E

更新日期：2016-02-01 00:00:00

abstract：:The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and t...

journal_title：Pain

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1992-11-01 00:00:00

abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...

journal_title：Pain

authors： Keefe FJ,Shelby RA,Somers TJ,Varia I,Blazing M,Waters SJ,McKee D,Silva S,She L,Blumenthal JA,O'Connor J,Knowles V,Johnson P,Bradley L

更新日期：2011-04-01 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a pain syndrome that is characterised by autonomic, motor and sensory disturbances. The syndrome has often been associated with sympathetic dysfunction. Therefore, we investigated whether there are disturbances in the sympathetic function of skin microcirculation in the various cl...

journal_title：Pain

authors： Kurvers HA,Jacobs MJ,Beuk RJ,Van den Wildenberg FA,Kitslaar PJ,Slaaf DW,Reneman RS

更新日期：1995-03-01 00:00:00

abstract：ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...

journal_title：Pain

authors： Agalave NM,Rudjito R,Farinotti AB,Khoonsari PE,Sandor K,Nomura Y,Szabo-Pardi TA,Urbina CM,Palada V,Price TJ,Erlandsson Harris H,Burton MD,Kultima K,Svensson CI

更新日期：2021-02-01 00:00:00

abstract：:The literature on cognitive and cognitive-behavioral methods for pain control is selectively reviewed, with particular focus on controlled studies. Such methods include the provision of preparatory information, cognitive coping skills or strategies, the provision of preparatory information plus some form of coping ski...

journal_title：Pain

authors： Tan SY

更新日期：1982-03-01 00:00:00