Abstract:
ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly addressed. Here, we examined whether the action of TLR4-activating, partially reduced disulfide HMGB1 on microglia induces nociceptive behaviors in a sex-dependent manner. We found disulfide HMGB1 to equally increase microglial Iba1 immunoreactivity in lumbar spinal dorsal horn in male and female mice, but evoke higher cytokine and chemokine expression in primary microglial culture derived from males compared to females. Interestingly, TLR4 ablation in myeloid-derived cells, which include microglia, only protected male mice from developing HMGB1-induced mechanical hypersensitivity. Spinal administration of the glial inhibitor, minocycline, with disulfide HMGB1 also prevented pain-like behavior in male mice. To further explore sex difference, we examined the global spinal protein expression using liquid chromatography-mass spectrometry and found several antinociceptive and anti-inflammatory proteins to be upregulated in only male mice subjected to minocycline. One of the proteins elevated, alpha-1-antitrypsin, partially protected males but not females from developing HMGB1-induced pain. Targeting downstream proteins of alpha-1-antitrypsin failed to produce robust sex differences in pain-like behavior, suggesting that several proteins identified by liquid chromatography-mass spectrometry are required to modulate the effects. Taken together, the current study highlights the importance of mapping sex dimorphisms in pain mechanisms and point to processes potentially involved in the spinal antinociceptive effect of microglial inhibition in male mice.
journal_name
Painjournal_title
Painauthors
Agalave NM,Rudjito R,Farinotti AB,Khoonsari PE,Sandor K,Nomura Y,Szabo-Pardi TA,Urbina CM,Palada V,Price TJ,Erlandsson Harris H,Burton MD,Kultima K,Svensson CIdoi
10.1097/j.pain.0000000000002033subject
Has Abstractpub_date
2021-02-01 00:00:00pages
446-458issue
2eissn
0304-3959issn
1872-6623pii
00006396-202102000-00012journal_volume
162pub_type
杂志文章相关文献
PAIN文献大全abstract::Poor women and women of color are disproportionately affected by HIV and this is particularly evident in sub-Saharan Africa. Even with increased access to antiretroviral therapy that makes HIV/AIDS a chronic manageable condition, little progress has been made to address the issues of pain caused by HIV disease in wome...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2007.10.009
更新日期:2007-11-01 00:00:00
abstract::Current treatments for post-injury movement-evoked pain are inadequate. Non-opioids may complement opioids, which preferentially reduce spontaneous pain, but most have incomplete efficacy as single agents. This trial evaluates efficacy of a gabapentin-rofecoxib combination following hysterectomy. In addition to IV-PCA...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2004.10.008
更新日期:2005-01-01 00:00:00
abstract::Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may unde...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.04.035
更新日期:2004-07-01 00:00:00
abstract::Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001193
更新日期:2018-06-01 00:00:00
abstract::The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.02.027
更新日期:2005-05-01 00:00:00
abstract::Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00077-0
更新日期:2003-08-01 00:00:00
abstract::Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00093-6
更新日期:1997-11-01 00:00:00
abstract::Substance P like immunoreactivity (SPLI) and total protein (TP) concentrations in plasma and saliva were measured in 80 healthy female patients divided into the following four groups: women in group 1 were not pregnant and they were awaiting tubal ligation; women in group 2 were not pregnant but they experienced acute...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(96)03258-7
更新日期:1997-02-01 00:00:00
abstract::Evidence has shown that electrical stimulation at the dorsal columns attenuated the "wind-up" phenomenon in dorsal horn neurons in nerve-injured rats. This study was aimed to test the effect of spinal cord stimulation (SCS) on temporal summation (TS), the clinical correlate of the wind-up phenomenon in patients with r...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.j.pain.0000460342.69718.a2
更新日期:2015-03-01 00:00:00
abstract::Chronic neuropathic pain is associated with long-term changes at multiple levels of the neuroaxis, including in the brain, where electrical stimulation has been used to manage severe pain conditions. However, the clinical outcome of deep brain stimulation is often mixed, and the mechanisms are poorly understood. By me...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.07.011
更新日期:2011-11-01 00:00:00
abstract::The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90118-U
更新日期:1992-07-01 00:00:00
abstract::(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90637-0
更新日期:1981-12-01 00:00:00
abstract::A preliminary report of clinical study revealed that chronic discogenic low back pain could be treated by intradiscal methylene blue (MB) injection. We investigated the effect of intradiscal MB injection for the treatment of chronic discogenic low back pain in a randomized placebo-controlled trial. We recruited 136 pa...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.01.021
更新日期:2010-04-01 00:00:00
abstract::Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00195-5
更新日期:2000-02-01 00:00:00
abstract::We investigated the question of how cultural and linguistic backgrounds affect relationships among ratings (reported by patients with metastatic cancer) of pain's interference with such functions as activity, mood, and sleep. Multidimensional scaling (MDS) was used to analyze ratings of pain interference from a sample...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(96)03131-4
更新日期:1996-10-01 00:00:00
abstract::In rats anesthetized with sodium pentobarbital, we quantitatively analyzed descending modulation from the midbrain of a nociceptive flexion withdrawal reflex and responses of associated spinal neurons. We monitored the isometric force of hind limb withdrawal elicited by noxious heat stimuli (42-54 degrees C, 10 sec) o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90061-F
更新日期:1992-02-01 00:00:00
abstract::Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed. Systematic literature reviews, randomized clinical trials, and existing guidelines were evaluated at a consensus meeting. Medications were considered for recommendation if ...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2007.08.033
更新日期:2007-12-05 00:00:00
abstract::We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001609
更新日期:2019-08-01 00:00:00
abstract::Cultures differ as to typical linguistic reports and classifications of pain. In some languages upwards of a dozen specific pain terms are in common use, each indicating a particular pain experience. In other languages a single inclusive term is the norm, perhaps with optional qualifiers added to make desired distinct...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(80)90025-1
更新日期:1980-08-01 00:00:00
abstract::There are contradictory findings about whether there are differences in personality and/or amount of emotional disturbance between patients with functional versus organic low back pain. The MMPI scores of 42 back pain patients diagnosed as "organic" were compared with the scores of 37 patients classified as "functiona...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90089-6
更新日期:1977-10-01 00:00:00
abstract::In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I-III. The main limitation has been the difficulty in defining functional populations among the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.05.001
更新日期:2013-12-01 00:00:00
abstract::The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90083-2
更新日期:1987-07-01 00:00:00
abstract::To date, patients with bony metastases were only a small fraction of the samples studied, or they were entirely excluded. Patients with metastatic cancers, such as bone metastases, are more likely to report pain, compared to patients without metastatic cancer (50-74% and 15%, respectively). Their cancer pain results i...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.06.021
更新日期:2011-10-01 00:00:00
abstract::Salmon calcitonin (s-CT) has been shown to be a valuable analgesic in phantom limb pain (PLP) in several case reports. To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe P...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90127-W
更新日期:1992-01-01 00:00:00
abstract::Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00177-2
更新日期:1998-02-01 00:00:00
abstract::Despite the presence of pathology in cancer pain, the pain experience in adult cancer patients cannot be totally explained by the extent of such pathology. Unlike chronic benign pain very little research on the role of biobehavioral factors has been conducted to help explain this paradox. The literature on the role of...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(88)90084-X
更新日期:1988-05-01 00:00:00
abstract::Patients with acute whiplash trauma were followed to examine if post-trauma ratings of pre-collision pain and psychological distress were associated with reduced work capability and neck pain at 12 months follow-up. The study included 740 consecutive patients (474 females, 266 males) referred from emergency department...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2008.04.008
更新日期:2008-10-15 00:00:00
abstract::The somatosensory abnormalities in 20 men and 7 women (mean age 67 years, range 53-81) with central post-stroke pain (CPSP) have been analysed in detail with traditional neurological tests and quantitative methods. The cerebrovascular lesions were located in the lower brain-stem in 8 patients, involved the thalamus in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90128-0
更新日期:1989-05-01 00:00:00
abstract::Endometriosis affects ∼176 million women worldwide, yet on average, women experience pain ∼10 years from symptom onset before being properly diagnosed. Standard treatments (drugs or surgery) often fail to provide long-term pain relief. Elevated levels of reactive aldehydes such as 4-hydroxynonenal (4-HNE) have been im...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001949
更新日期:2021-01-01 00:00:00
abstract::Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.023
更新日期:2014-11-01 00:00:00