High-frequency stimulation in the ventral posterolateral thalamus reverses electrophysiologic changes and hyperalgesia in a rat model of peripheral neuropathic pain.

abstract：:Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

journal_title：Pain

authors： Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

更新日期：2011-12-01 00:00:00

abstract：:Surgery and trauma are recognised as important causes of chronic pain, although their overall contribution has not been systematically studied. This paper reports on the contribution of surgery and trauma to chronic pain among 5130 patients attending 10 outpatient clinics located throughout North Britain. Surgery cont...

journal_title：Pain

authors： Crombie IK,Davies HT,Macrae WA

更新日期：1998-05-01 00:00:00

abstract：:Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipu...

journal_title：Pain

authors： Domenichiello AF,Jensen JR,Zamora D,Horowitz M,Yuan ZX,Faurot K,Mann JD,Mannes AJ,Ramsden CE

更新日期：2020-12-01 00:00:00

abstract：:Laser-evoked potentials (LEPs) are acknowledged as the most reliable laboratory tool for assessing thermal and pain pathways. Electrical stimulation with a newly developed planar concentric electrode, delivering stimuli limited to the superficial skin layers, has been suggested to provide selective activation of Aδ fi...

journal_title：Pain

authors： Perchet C,Frot M,Charmarty A,Flores C,Mazza S,Magnin M,Garcia-Larrea L

更新日期：2012-06-01 00:00:00

abstract：:Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...

journal_title：Pain

authors： Wang SY,Mitchell J,Wang GK

更新日期：2007-01-01 00:00:00

abstract：:Past research has shown that pain catastrophizing contributes to heightened pain experience. The hypothesis advanced in this study was that individuals who score high on measures of pain catastrophizing would also perceive more intense pain in others. The study also examined the role of pain behaviour as a determinant...

journal_title：Pain

authors： Sullivan MJ,Martel MO,Tripp DA,Savard A,Crombez G

更新日期：2006-07-01 00:00:00

abstract：:The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...

journal_title：Pain

authors： Kunz M,Lautenbacher S,LeBlanc N,Rainville P

更新日期：2012-02-01 00:00:00

abstract：:Twenty patients with chronic low back pain received 12 lumbar sympathetic injections, in a series of 6 with bupivacaine and a series of 6 with saline. Changes in subjective pain intensity, EMG from paravertebral muscles, joint ranges of mobility, and daily activity levels were measured at multiple intervals throughout...

journal_title：Pain

authors： Brena SF,Wolf SL,Chapman SL,Hammonds WD

更新日期：1980-02-01 00:00:00

abstract：:The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdo...

journal_title：Pain

authors： Miranda HF,Puig MM,Prieto JC,Pinardi G

更新日期：2006-03-01 00:00:00

abstract：:This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Stud...

journal_title：Pain

authors： Thakral M,Shi L,Foust JB,Patel KV,Shmerling RH,Bean JF,Leveille SG

更新日期：2016-12-01 00:00:00

abstract：:When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...

journal_title：Pain

authors： Seltzer Z,Cohn S,Ginzburg R,Beilin B

更新日期：1991-04-01 00:00:00

abstract：:The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...

journal_title：Pain

authors： Riley JL 3rd,Wade JB,Myers CD,Sheffield D,Papas RK,Price DD

更新日期：2002-12-01 00:00:00

abstract：:This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...

journal_title：Pain

authors： Nicholas MK,Wilson PH,Goyen J

更新日期：1992-03-01 00:00:00

abstract：:The aims of this study were two-fold: first, to simplify the method for creating a recently described neuropathic pain model in the rat, and second, to evaluate the effects of a number of drugs with analgesic or antihyperalgesic properties, in this model. Continuous intravenous vincristine infusion (1-100 microg kg(-1...

journal_title：Pain

authors： Nozaki-Taguchi N,Chaplan SR,Higuera ES,Ajakwe RC,Yaksh TL

更新日期：2001-07-01 00:00:00

abstract：:This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...

journal_title：Pain

authors： Sharpe L,Perry NK,Rogers P,Dear BF,Nicholas MK,Refshauge K

更新日期：2010-09-01 00:00:00

abstract：:Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define t...

journal_title：Pain

authors： Mogil JS,Wilson SG,Bon K,Lee SE,Chung K,Raber P,Pieper JO,Hain HS,Belknap JK,Hubert L,Elmer GI,Chung JM,Devor M

更新日期：1999-03-01 00:00:00

abstract：:Capture-recapture methods are increasingly used to determine the prevalence of numerous chronic conditions but have never been used in the context of chronic pain (CP). This study sought to provide up-to-date estimates of the prevalence of people experiencing CP ± neuropathic characteristics in France using the captur...

journal_title：Pain

authors： Chenaf C,Delorme J,Delage N,Ardid D,Eschalier A,Authier N

更新日期：2018-11-01 00:00:00

abstract：:Changes in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain...

journal_title：Pain

authors： Roy A,Wang WE,Ho RLM,Ribeiro-Dasilva MC,Fillingim RB,Coombes SA

更新日期：2018-12-01 00:00:00

abstract：:Adolescents with chronic pain are at risk for impairment in their friendships. They miss out on leisure activities, have increased school absence, may have fewer friends, are at an increased risk for victimization, and may be perceived by peers as less likeable. To help determine the source of these problems, the Soci...

journal_title：Pain

authors： Forgeron PA,McGrath P,Stevens B,Evans J,Dick B,Finley AG,Carlson T

更新日期：2011-12-01 00:00:00

abstract：:Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysf...

journal_title：Pain

authors： Liu S,Huang Q,He S,Chen Z,Gao X,Ma D,Duan W,Ford N,Yang F,Chen X,Raja SN,Hao D,Guan Y

更新日期：2019-12-01 00:00:00

abstract：:Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical and cold sensitivity in neuropathic pain and therefore offered a new a...

journal_title：Pain

authors： Obara I,Medrano MC,Signoret-Genest J,Jiménez-Díaz L,Géranton SM,Hunt SP

更新日期：2015-08-01 00:00:00

abstract：:The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...

journal_title：Pain

authors： Haythornthwaite JA,Sieber WJ,Kerns RD

更新日期：1991-08-01 00:00:00

abstract：:Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...

journal_title：Pain

authors： Sagen J,Winker MA,Proudfit HK

更新日期：1983-07-01 00:00:00

abstract：:Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...

journal_title：Pain

authors： Reyes-Gibby CC,Shete S,Rakvåg T,Bhat SV,Skorpen F,Bruera E,Kaasa S,Klepstad P

更新日期：2007-07-01 00:00:00

abstract：:Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...

journal_title：Pain

authors： Roza C,Reeh PW

更新日期：2001-09-01 00:00:00

abstract：:Peripheral nerve injury produces a persistent neuropathic pain state characterized by spontaneous pain, allodynia and hyperalgesia. In this study, we evaluated the possible involvement of A 2ARs in the development of neuropathic pain and the expression of microglia and astrocytes in the spinal cord after sciatic nerve...

journal_title：Pain

authors： Bura AS,Nadal X,Ledent C,Maldonado R,Valverde O

更新日期：2008-11-15 00:00:00

abstract：:Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...

journal_title：Pain

authors： Kamerman PR,Bradshaw D,Laubscher R,Pillay-van Wyk V,Gray GE,Mitchell D,Chetty S

更新日期：2020-07-01 00:00:00

abstract：:Temporomandibular disorders (TMD) represent a group of chronic painful conditions involving the muscles of mastication and the temporomandibular joint. Several studies have reported that TMD is associated with enhanced sensitivity to experimental pain. Twenty-three TMD subjects and 24 pain-free matched control subject...

journal_title：Pain

authors： Maixner W,Fillingim R,Sigurdsson A,Kincaid S,Silva S

更新日期：1998-05-01 00:00:00

abstract：:Morphine is widely used to treat severe pain in neonatal intensive care unit patients. Animal studies suggest adverse long-term side effects of neonatal morphine, but a follow-up study of 5-year-old children who participated in a morphine-placebo controlled trial as newborns found no such effects on the child's genera...

journal_title：Pain

authors： de Graaf J,van Lingen RA,Valkenburg AJ,Weisglas-Kuperus N,Jebbink LG,Wijnberg-Williams B,Anand KJS,Tibboel D,van Dijk M

更新日期：2013-03-01 00:00:00

abstract：:In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...

journal_title：Pain

authors： Bailey B,Gravel J,Daoust R

更新日期：2012-04-01 00:00:00