Abstract:
:Twenty patients with chronic low back pain received 12 lumbar sympathetic injections, in a series of 6 with bupivacaine and a series of 6 with saline. Changes in subjective pain intensity, EMG from paravertebral muscles, joint ranges of mobility, and daily activity levels were measured at multiple intervals throughout treatment and at 3 monthly follow-up intervals. The MMPI was administered before treatment, after treatment and at 3-month follow-up. Results revealed significant reductions in subjective pain intensity lasting 1 month after treatment which were not significantly different during bupivacaine and saline injection periods. Patients' MMPI profiles were indicative of reduced depression and an increase in ability to manage their lives. No significant changes were recorded with respect to EMG, joint range of mobility, or daily activity levels. Results were discussed in terms of a massive placebo effect and analgesia obtained through hyperstimulation of various tissue structures. They are consistent with the hypothesis that central postsynaptic mechanisms were predominant in these patients' chronic back pain states. Because subjective pain relief did not independently produce increasing function, it was recommended that deep analgesic injections or other pain relieving techniques be matched with behavior modification leading to functional rehabilitation.
journal_name
Painjournal_title
Painauthors
Brena SF,Wolf SL,Chapman SL,Hammonds WDdoi
10.1016/0304-3959(80)90085-8subject
Has Abstractpub_date
1980-02-01 00:00:00pages
1-10issue
1eissn
0304-3959issn
1872-6623pii
00006396-198002000-00001journal_volume
8pub_type
临床试验,杂志文章相关文献
PAIN文献大全abstract::The cybernetic model of analgesia is a simple servo-loop: altered sensory input--complaints--medication--temporary restoration of acceptable processing of the sensory input--return of altered sensations. Under ordinary clinical circumstances the functioning of this mechanism is masked by "noise" generated by the inter...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(79)90129-5
更新日期:1979-04-01 00:00:00
abstract::Effects of electrical stimulation of the cervical vagus nerve were determined in cervical or lumbar spinal neurons in 27 rats anesthetized with pentobarbital. Ipsilateral cervical vagus stimulation (ICVS) increased activity of 44 neurons in the C1 segment. At the same stimulation parameters, contralateral cervical vag...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90013-2
更新日期:1992-10-01 00:00:00
abstract::The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(98)00232-2
更新日期:1999-03-01 00:00:00
abstract::microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.11.010
更新日期:2013-03-01 00:00:00
abstract::The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03243-5
更新日期:1997-01-01 00:00:00
abstract::Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00143-7
更新日期:1998-01-01 00:00:00
abstract::On a no treatment trial, a group of 24 oriental subjects rated cold pressor pain as significantly more painful and distressing than did a group of 24 occidental subjects. For half of the Orientals and half of the Occidentals, a second trial was conducted after acupuncture analgesia had been induced. The remaining 12 O...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90086-0
更新日期:1977-10-01 00:00:00
abstract::Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90009-2
更新日期:1989-11-01 00:00:00
abstract::Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ("autotomy"). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited tr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00295-0
更新日期:2001-08-01 00:00:00
abstract::The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(97)00174-7
更新日期:1998-02-01 00:00:00
abstract::The treatment of neuropathic pain remains a clinical challenge because of its unclear mechanisms and broad clinical morbidity. Matrix metalloproteinase (MMP)-9 and MMP-2 have previously been described as key components in neuropathic pain because of their facilitation of inflammatory cytokine maturation and induction ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000575
更新日期:2016-08-01 00:00:00
abstract::Many treatments used for women with vulvodynia are based solely upon expert opinion. This randomized trial aimed to test the relative efficacy of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) in women with vulvodynia. Of the 50 participants, 42 (84%) completed 10-week treatments and 47 (94%) co...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2008.09.031
更新日期:2009-01-01 00:00:00
abstract::The aim of this study was to determine the efficacy of transcutaneous electrical nerve stimulation (TENS) in the treatment of chronic stable severe angina pectoris. In a short-term study the effect of TENS was studied in 10 male patients with angina pectoris (functional class III and IV). All patients had previously b...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(86)90058-8
更新日期:1986-09-01 00:00:00
abstract::Measurement of depression and other mood states in pain patients has been criticised in recent years on the grounds that most questionnaires were not developed in pain populations and suffer from criterion contamination by somatic items. In addition, there is no accepted measurement for positive emotions which are mor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.02.004
更新日期:2004-05-01 00:00:00
abstract::Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.08.008
更新日期:2007-01-01 00:00:00
abstract::In previous studies we demonstrated that protein kinase D1 (PKD1/PKCmu) could directly phosphorylate the transient receptor potential V1 (TRPV1) at its N-terminal region and enhance the function of TRPV1 in CHO cells stably transfected with TRPV1. In the current study we assessed the involvement of PKD1 in pain modula...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.10.025
更新日期:2008-07-31 00:00:00
abstract::The purpose of this article is to review the sixteen published studies that examine associations between the perception of experimentally induced pain across menstrual cycle phases of healthy females. We also performed a meta-analysis to quantitatively analyze the data and attempt to draw conclusions. The results sugg...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/S0304-3959(98)00258-9
更新日期:1999-06-01 00:00:00
abstract::The influence of contextual factors on the pain evoked by a noxious stimulus is not well defined. In this study, a -20 degrees C rod was placed on one hand for 500 ms while we manipulated the evaluative context (or 'meaning') of, warning about, and visual attention to, the stimulus. For meaning, a red (hot, more tissu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.03.002
更新日期:2007-12-15 00:00:00
abstract::The aim of this study was to investigate the relationship between psychosocial work characteristics and neck and upper limb symptoms and to examine to what extent this relationship could be explained by other risk factors. Data were used from a prospective cohort study in a working population, with a follow-up period ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.008
更新日期:2005-03-01 00:00:00
abstract::The GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission was studied from young rat substantia gelatinosa (SG) neurons using a conventional whole-cell patch clamp technique. Action potential-dependent glycinergic inhibitory postsynaptic currents (IPSCs) were recorded from SG neurons in the pres...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.005
更新日期:2008-08-31 00:00:00
abstract::Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00192-1
更新日期:1996-03-01 00:00:00
abstract::Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00181-1
更新日期:2002-10-01 00:00:00
abstract::Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2014.08.036
更新日期:2014-11-01 00:00:00
abstract::Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001844
更新日期:2020-07-01 00:00:00
abstract::A previous study of this laboratory showed that an acute myositis (which is associated with increased activity in slowly conducting muscle afferent fibres) is followed by marked excitability changes in the dorsal horn within a few hours. The present work addresses the question as to how the responsiveness of dorsal ho...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00105-N
更新日期:1995-02-01 00:00:00
abstract::Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00177-2
更新日期:1998-02-01 00:00:00
abstract::Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.025
更新日期:2008-07-01 00:00:00
abstract::The purpose of this study is to analyze cancer breakthrough pain (BP) characteristics and how BP responds to conventional cancer pain management. Seventy-four cancer pain patients with worst pain severity >or=4 out of 10 completed the Brief Pain Inventory (BPI), Memorial Symptom Assessment Scale-Short Form, Functional...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(02)00293-2
更新日期:2003-01-01 00:00:00
abstract::Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.05.017
更新日期:2012-10-01 00:00:00
abstract::Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.03.026
更新日期:2011-09-01 00:00:00