GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission onto substantia gelatinosa neurons in the rat spinal cord.


:The GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission was studied from young rat substantia gelatinosa (SG) neurons using a conventional whole-cell patch clamp technique. Action potential-dependent glycinergic inhibitory postsynaptic currents (IPSCs) were recorded from SG neurons in the presence of 3 mM kynurenic acid and 10 microM SR95531. In these conditions, baclofen (30 microM), a selective GABA(B) receptor agonist, greatly reduced the amplitude of glycinergic IPSCs and increased the paired-pulse ratio. Such effects were completely blocked by 3 microM CGP55845, a selective GABA(B) receptor antagonist, indicating that the activation of presynaptic GABA(B) receptors decreases glycinergic synaptic transmission. Glycinergic IPSCs were largely dependent on Ca2+ influxes passing through presynaptic N- and P/Q-type Ca2+ channels, and these channels contributed equally to the baclofen-induced inhibition of glycinergic IPSCs. However, the baclofen-induced inhibition of glycinergic IPSCs was not affected by either 100 microM SQ22536, an adenylyl cyclase inhibitor, or 1 mM Ba2+, a G-protein coupled inwardly rectifying K+ channel blocker. During the train stimulation (10 pulses at 20 Hz), which caused a marked synaptic depression of glycinergic IPSCs, baclofen at a 30 microM concentration completely blocked glycinergic synaptic depression, but at a 3 microM concentration it largely preserved glycinergic synaptic depression. Such GABA(B) receptor-mediated dynamic changes in short-term synaptic plasticity of glycinergic transmission onto SG neurons might contribute to the central processing of sensory signals.






Choi IS,Cho JH,Jeong SG,Hong JS,Kim SJ,Kim J,Lee MG,Choi BJ,Jang IS




Has Abstract


2008-08-31 00:00:00
















  • Fear-avoidance beliefs and distress in relation to disability in acute and chronic low back pain.

    abstract::Patients with chronic low back pain (LBP) frequently demonstrate high scores for fear-avoidance beliefs and distress. We need better knowledge about fear-avoidance beliefs and distress in early stages of LBP. The objectives of this study were to compare the level of fear-avoidance beliefs and distress in patients with...


    pub_type: 杂志文章


    authors: Grotle M,Vøllestad NK,Veierød MB,Brox JI

    更新日期:2004-12-01 00:00:00

  • Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors.

    abstract::Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...


    pub_type: 杂志文章


    authors: Andreou AP,Holland PR,Lasalandra MP,Goadsby PJ

    更新日期:2015-03-01 00:00:00

  • Disproportionate longer-term opioid use among U.S. adults with mood disorders.

    abstract::Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...


    pub_type: 杂志文章


    authors: Halbert BT,Davis RB,Wee CC

    更新日期:2016-11-01 00:00:00

  • New approach for investigating neuropathic allodynia by optogenetics.

    abstract::Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodyni...


    pub_type: 杂志文章,评审


    authors: Tsuda M

    更新日期:2019-05-01 00:00:00

  • Psychological aspects of reflex sympathetic dystrophy: a review of the adult and paediatric literature.

    abstract::In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...


    pub_type: 杂志文章,评审


    authors: Lynch ME

    更新日期:1992-06-01 00:00:00

  • Pharmacological modulations on the nociceptive flexion reflex in man.

    abstract::Pharmacological actions on the nociceptive flexion flexes of the hindlimb were investigated in 14 normal subjects. These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal recep...


    pub_type: 杂志文章


    authors: Willer JC,Bathien N

    更新日期:1977-04-01 00:00:00

  • Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion.

    abstract::We have developed a model in which inflammation contiguous to and within a dorsal root ganglion (DRG) was generated by local application of complete Freund's adjuvant (CFA) to the L4 lumbar spinal nerve as it exits from the intervertebral foramen. The periganglionic inflammation (PGI) elicited a marked reduction in wi...


    pub_type: 杂志文章


    authors: Amaya F,Samad TA,Barrett L,Broom DC,Woolf CJ

    更新日期:2009-03-01 00:00:00

  • Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain.

    abstract::Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We evaluated this plasticity by recording responses to mechanical stimuli in silent neurons (nonspontaneously active [NSA]) and neurons showing on...


    pub_type: 杂志文章


    authors: Medrano MC,Dhanasobhon D,Yalcin I,Schlichter R,Cordero-Erausquin M

    更新日期:2016-07-01 00:00:00

  • Gabapentin induced polyneuropathy.

    abstract::Gabapentin is an effective option for the treatment of neuropathic pain syndromes because of its efficacy and favorable side-effect profile. A case is presented of a 58 year old man who developed a painful polyneuropathy while being treated with gabapentin. ...


    pub_type: 杂志文章


    authors: Gould HJ

    更新日期:1998-02-01 00:00:00

  • Pain-related musculoskeletal disorders, psychological comorbidity, and the relationship with physical and mental well-being in Gulf War veterans.

    abstract::Occupational activities such as lifting loads, working in constrained spaces, and training increase the risk of pain-related musculoskeletal disorders (MSDs) in military veterans. Few studies have investigated MSD and psychological disorder in veterans, and previous studies had limitations. This cross-sectional study ...


    pub_type: 杂志文章


    authors: Kelsall HL,McKenzie DP,Forbes AB,Roberts MH,Urquhart DM,Sim MR

    更新日期:2014-04-01 00:00:00

  • Cutaneous pain threshold changes after sympathetic block in reflex dystrophies.

    abstract::In a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 day...


    pub_type: 杂志文章


    authors: Procacci P,Francini F,Zoppi M,Maresca M

    更新日期:1975-06-01 00:00:00

  • Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia.

    abstract::The aim of this study was to investigate how exercise influenced endogenous pain modulation in healthy controls, shoulder myalgia patients and fibromyalgia (FM) patients. Twenty-one healthy subjects, 20 shoulder myalgia patients and 20 FM patients, all females, participated. They performed standardized static contract...


    pub_type: 杂志文章


    authors: Lannersten L,Kosek E

    更新日期:2010-10-01 00:00:00

  • Surgical management of neuroma pain: a prospective follow-up study.

    abstract::Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...


    pub_type: 杂志文章


    authors: Stokvis A,van der Avoort DJC,van Neck JW,Hovius SER,Coert HJ

    更新日期:2010-12-01 00:00:00

  • Serotonin-containing neurons: their possible role in pain and analgesia.

    abstract::Experimental evidence is reviewed showing that brain and spinal cord serotonergic neurons are involved in nociceptive responses, as well as in the analgesic effects of opiate narcotics. This evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervo...


    pub_type: 杂志文章,评审


    authors: Messing RB,Lytle LD

    更新日期:1977-10-01 00:00:00

  • Medically incongruent chronic back pain: physical limitations, suffering, and ineffective coping.

    abstract::Chronic low back pain (CLBP) patients with pain and symptomatology incongruent with physical pathology have been found to have a poorer outcome to medical treatment and rehabilitation, and to use health care resources excessively. To examine possible psychological and behavioral bases for this pattern, this investigat...


    pub_type: 杂志文章


    authors: Reesor KA,Craig KD

    更新日期:1988-01-01 00:00:00

  • Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.

    abstract::The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...


    pub_type: 杂志文章


    authors: Sawynok J,Reid AR,Doak GJ

    更新日期:1995-05-01 00:00:00

  • Unexpected association of the "inhibitory" neuroligin 2 with excitatory PSD95 in neuropathic pain.

    abstract::In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...


    pub_type: 杂志文章


    authors: Dolique T,Favereaux A,Roca-Lapirot O,Roques V,Léger C,Landry M,Nagy F

    更新日期:2013-11-01 00:00:00

  • Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat.

    abstract::Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which augments these currents. Prostaglandin D(2) (PGD(2)) is released in the tissue to...


    pub_type: 杂志文章


    authors: Ebersberger A,Natura G,Eitner A,Halbhuber KJ,Rost R,Schaible HG

    更新日期:2011-05-01 00:00:00

  • Evoked bursting in injured Aβ dorsal root ganglion neurons: a mechanism underlying tactile allodynia.

    abstract::Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). T...


    pub_type: 杂志文章


    authors: Song Y,Li HM,Xie RG,Yue ZF,Song XJ,Hu SJ,Xing JL

    更新日期:2012-03-01 00:00:00

  • Mechanisms of referred visceral pain: uterine inflammation in the adult virgin rat results in neurogenic plasma extravasation in the skin.

    abstract::The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...


    pub_type: 杂志文章


    authors: Wesselmann U,Lai J

    更新日期:1997-12-01 00:00:00

  • Heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in chronic tension-type headache.

    abstract::Current opinion concerning the pathophysiology of tension-type headache (TTH) and its related pericranial muscle tenderness proposes a primary role of central sensitization at the level of dorsalhorn/trigeminal nucleus as well as the supraspinal level. Investigation of these phenomena can be conducted using laser-evok...


    pub_type: 杂志文章


    authors: de Tommaso M,Libro G,Guido M,Sciruicchio V,Losito L,Puca F

    更新日期:2003-07-01 00:00:00

  • Nociceptive nerve activity in an experimental model of knee joint osteoarthritis of the guinea pig: effect of intra-articular hyaluronan application.

    abstract::Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...


    pub_type: 杂志文章


    authors: Gomis A,Miralles A,Schmidt RF,Belmonte C

    更新日期:2007-07-01 00:00:00

  • Chronic gynaecological pain: an exploration of medical attitudes.

    abstract::Women with chronic pelvic pain experience serious distress and lifestyle disruption. Confronted with a difficult condition to diagnose and treat effectively, doctors express a negative perception of this group of 'heartsink' patients. This study aimed to characterise medical attitudes towards the treatment of women wi...


    pub_type: 杂志文章


    authors: Selfe SA,Van Vugt M,Stones WR

    更新日期:1998-08-01 00:00:00

  • Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects.

    abstract::Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from pain research units exp...


    pub_type: 杂志文章,多中心研究


    authors: Vollert J,Attal N,Baron R,Freynhagen R,Haanpää M,Hansson P,Jensen TS,Rice ASC,Segerdahl M,Serra J,Sindrup SH,Tölle TR,Treede RD,Maier C

    更新日期:2016-03-01 00:00:00

  • Do beliefs, coping, and catastrophizing independently predict functioning in patients with chronic pain?

    abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...


    pub_type: 临床试验,杂志文章


    authors: Turner JA,Jensen MP,Romano JM

    更新日期:2000-03-01 00:00:00

  • Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.

    abstract::Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...


    pub_type: 杂志文章


    authors: Chacur M,Gutiérrez JM,Milligan ED,Wieseler-Frank J,Britto LR,Maier SF,Watkins LR,Cury Y

    更新日期:2004-09-01 00:00:00

  • Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats.

    abstract::Single units were recorded in dorsal roots or in the sciatic nerve of anaesthetised rats. It was shown by making sections, by stimulation and by collision that some ongoing nerve impulses were originating from the dorsal root ganglia and not from the central or peripheral ends of the axons. In a sample of 2731 intact ...


    pub_type: 杂志文章


    authors: Wall PD,Devor M

    更新日期:1983-12-01 00:00:00

  • A cross-national study of the course of persistent pain in primary care.

    abstract::Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...


    pub_type: 杂志文章


    authors: Gureje O,Simon GE,Von Korff M

    更新日期:2001-05-01 00:00:00

  • Does fear of movement mediate the relationship between pain intensity and disability in patients following whiplash injury? A prospective longitudinal study.

    abstract::The aim of this study was to test the capacity of the Fear Avoidance Model to explain the relationship between pain and disability in patients with whiplash-associated disorders. Using the method of Baron and Kenny, we assessed the mediating effect of fear of movement on the cross-sectional and longitudinal relationsh...


    pub_type: 杂志文章


    authors: Kamper SJ,Maher CG,Menezes Costa LDC,McAuley JH,Hush JM,Sterling M

    更新日期:2012-01-01 00:00:00

  • Acupuncture and chronic pain mechanisms.

    abstract::Forty patients with chronic pain below the waist level not amenable to conventional medical and/or surgical treatment were randomly assigned to one or two different methods of acupuncture, after studying the underlying pain mechanisms using a Multidisciplinary Pain Clinic approach and the differential spinal block (DS...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ghia JN,Mao W,Toomey TC,Gregg JM

    更新日期:1976-09-01 00:00:00