Abstract：
:Previous research has demonstrated that intravenously administered cannabinoids produce potent antinociception in rodents. The present study examined the ability of 16 cannabinoid analogs to produce antinociception and hypothermia after intrathecal administration. Fifteen of the compounds tested produced significant increases in the tail-flick response to radiant heat. This effect was stereoselective because N-methyl-dextronantradol, the inactive stereo-isomer of the potent cannabinoid analog N-methyl-levonantradol, failed to elevate tail-flick latencies above baseline values. In general, the drugs tended to be more effective in producing hypothermia than antinociception. A positive correlation found between the ED50 values in producing antinociception and lipophilicity indicated that the most lipid-soluble drugs were the least active. In contrast, no apparent relationship between cannabinoid-induced hypothermia and lipophilicity was found. The finding that the antinociceptive effects of spinally administered cannabinoids is inversely related to lipophilicity is similar to that reported for the opiates.
journal_name
Painjournal_title
Painauthors
Lichtman AH,Smith PB,Martin BRdoi
10.1016/0304-3959(92)90004-Ukeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
19-26issue
1eissn
0304-3959issn
1872-6623pii
00006396-199210000-00003journal_volume
51pub_type
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