Abstract:
:The spinal ascending pathways responsible for neuronal ventrobasal (VB) thalamic responses elicited by joint stimulation of the posterior paw were determined in arthritic rats used as a model of experimental pain. Responses of a same neurone to mechanical (movement--pressure--brushing) or thermal stimulation (50 degrees C) were analysed before and after discrete lesions in the white matter of the spinal cord. For 6 neurones responding exclusively to brushing applied on a small receptive field (RF) strictly contralateral to the recording site, responses were not altered as long as the contralateral dorsal column was intact. Twenty neurones exhibited bilateral symmetrical RF located on the posterior paws including the ankles and for some units the digits. They were driven by moderate pressure and/or mild sustained joint movement and by immersion in a hot water bath at 50 degrees C. Their responses were not significantly modified when the lesions destroyed most of the dorsal and the dorsolateral parts of the spinal cord. In 16/20 cases effect of one hemisection of the cord was studied: when the hemisection was contralateral to the recording site (n = 8) VB neuronal responses elicited from the paw ipsilateral to this side were eliminated in 6/8 cases; when the 1/2 section was ipsilateral to the recording site (n = 8) the lesion induced the elimination of the responses elicited from the paw opposite to the recorded VB for one unit only. The involvement of the spino-reticular pathways which have not only a crossed but also a non-crossed component is suggested. This hypothesis is discussed by comparison to data previously obtained, showing that by contrast in healthy rats the spino-thalamic tract is essential for VB neuronal responses to noxious stimuli.
journal_name
Painjournal_title
Painauthors
Guilbaud G,Peschanski M,Briand A,Gautron Mdoi
10.1016/0304-3959(86)90059-Xsubject
Has Abstractpub_date
1986-09-01 00:00:00pages
301-312issue
3eissn
0304-3959issn
1872-6623pii
00006396-198609000-00004journal_volume
26pub_type
杂志文章相关文献
PAIN文献大全abstract::We assessed for the first time the long-term maintenance of repetitive transcranial magnetic stimulation (rTMS)-induced analgesia in patients with chronic widespread pain due to fibromyalgia. Forty consecutive patients were randomly assigned, in a double-blind fashion, to 2 groups: one receiving active rTMS (n=20) and...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.01.034
更新日期:2011-07-01 00:00:00
abstract::The antinociception effect of clomipramine and the combination of clomipramine and morphine was evaluated using the constant temperature hot plate test, the increasing temperature hot plate test and the formalin test in mice. Both a single dose of clomipramine (10 mg/kg) given intraperitoneally (i.p.) and chronic clom...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90295-3
更新日期:1988-06-01 00:00:00
abstract::Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (ce...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00420-7
更新日期:2003-05-01 00:00:00
abstract::Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000890
更新日期:2017-06-01 00:00:00
abstract::The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00155-4
更新日期:1999-12-01 00:00:00
abstract::In this review, the effectiveness of behavioral and pharmacological treatments for pediatric migraine was quantitatively summarized following the meta-analytic approach outlined by Hedges and Olkin (1985). A first meta-analysis based on treatment outcome within treatment conditions revealed that thermal biofeedback an...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/0304-3959(94)00210-6
更新日期:1995-03-01 00:00:00
abstract::The effects of vibratory stimulation on muscular pain threshold were investigated in 28 healthy subjects. Pain sensation was evaluated by the subjects' verbal reports in response to electrical stimulation of the vastus medialis muscle. Concomitant variations of blink response evoked as a component of the startle react...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90046-1
更新日期:1986-02-01 00:00:00
abstract::Since a number of patients with Parkinson's Disease (PD) complain of painful sensations, we studied whether the central processing of nociceptive inputs is abnormal in PD. To test this hypothesis, we recorded scalp CO(2) laser evoked potentials (LEPs) to hand skin stimulation in 18 pain-free PD patients with unilatera...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.06.022
更新日期:2008-05-01 00:00:00
abstract::Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00120-1
更新日期:1998-11-01 00:00:00
abstract::Cognitive strategies have received considerable interest in pain management, alongside the traditional approaches of physical intervention and behavior modification. However, the literature on these strategies is ridden with inconsistencies of terminology that present major difficulties in the conceptualization and ev...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(86)90070-9
更新日期:1986-08-01 00:00:00
abstract::We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2006.03.020
更新日期:2006-09-01 00:00:00
abstract::Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001330
更新日期:2018-11-01 00:00:00
abstract::Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90180-J
更新日期:1992-04-01 00:00:00
abstract::The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...
journal_title:Pain
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0304-3959(99)00121-9
更新日期:1999-11-01 00:00:00
abstract::Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90012-4
更新日期:1982-07-01 00:00:00
abstract::Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the ability of the fun...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00270-1
更新日期:2002-10-01 00:00:00
abstract::This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.12.018
更新日期:2012-04-01 00:00:00
abstract::The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the habituation to pain has never been evaluated. Our aim was to assess the nociceptive pathway function and the habituation to experimental pain in patients with migraine. Scalp potentials were evoked by CO(2) laser s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00137-4
更新日期:2003-09-01 00:00:00
abstract::Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90009-2
更新日期:1989-11-01 00:00:00
abstract::Little is known about patients prescribed high doses of opioids to treat chronic non-cancer pain, though these patients may be at higher risk for medication-related complications. We describe the prevalence of high-dose opioid use and associated demographic and clinical characteristics among veterans treated in a VA r...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.002
更新日期:2010-12-01 00:00:00
abstract::We investigated whether intraoperative 'subanesthetic doses' of ketamine have a postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of administration, either systemic (intravenous, i.v.) or epidural. One hundred patients scheduled for rectal adenocarcinoma surgery under combined...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(01)00278-0
更新日期:2001-06-01 00:00:00
abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2004.06.013
更新日期:2004-09-01 00:00:00
abstract::Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(00)00483-8
更新日期:2001-05-01 00:00:00
abstract::Internet-based educational and therapeutic programs (e-health applications) are becoming increasingly popular for a variety of psychological and physical disorders. We tested the efficacy of an online Chronic Pain Management Program, a comprehensive, fully self-directed and self-paced system that integrates social net...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.10.025
更新日期:2012-02-01 00:00:00
abstract::The purpose of this study was to examine the utility of the pain map as a pain assessment tool in frail nursing home residents. The study was conducted in two phases. In Phase 1, nursing home staff's knowledge of the locations of resident pain complaints was examined. We found significant deficiencies in this knowledg...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(98)00059-1
更新日期:1998-05-01 00:00:00
abstract::The aim of the study was to investigate to what extent cortical hyper-reactivity to visual stimuli is present in upper limb amputees. Five amputees with phantom limb pain (PLP), five amputees without PLP (Non-PLP) and 10 healthy controls (HC) were investigated using a visual oddball paradigm. Two hundred visual stimul...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.03.003
更新日期:2004-07-01 00:00:00
abstract::The efficacy of psychological treatments emphasising a self-management approach to chronic pain has been demonstrated by substantial empirical research. Nevertheless, high drop-out and relapse rates and low or unsuccessful engagement in self-management pain rehabilitation programs have prompted the suggestion that peo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00493-6
更新日期:2002-05-01 00:00:00
abstract::Current knowledge on pain-related cerebral networks has relied so far on stimulus-induced brain responses, but not on the analysis of brain activity during spontaneous pain attacks. In this case report, correlation between intracerebral field potentials and online sensations during spontaneously painful epileptic seiz...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.025
更新日期:2011-04-01 00:00:00
abstract::Potential applications of attention bias modification (ABM) for acute and chronic pain patients are investigated. In study 1, 54 acute back pain patients (46 of whom completed the study) were recruited at their initial physiotherapy session and randomised to receive 1 session of ABM or placebo. Patients were followed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.12.014
更新日期:2012-03-01 00:00:00