Abstract:
:Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In turn, EMG activation preceded visible tail flick by about 0.09 sec. In 13 other animals ventrobasal thalamic unitary responses were recorded simultaneously with on- and off-cell responses. On-cell bursts or off-cell pauses always preceded thalamic responses by about 0.4 sec. These results support the notion that on- and off-cells play a regulatory role in both segmental and ascending nociceptive transmission.
journal_name
Painjournal_title
Painauthors
Hernández N,López Y,Vanegas Hdoi
10.1016/0304-3959(89)90009-2subject
Has Abstractpub_date
1989-11-01 00:00:00pages
221-230issue
2eissn
0304-3959issn
1872-6623pii
00006396-198911000-00009journal_volume
39pub_type
杂志文章相关文献
PAIN文献大全abstract::Current treatments for post-injury movement-evoked pain are inadequate. Non-opioids may complement opioids, which preferentially reduce spontaneous pain, but most have incomplete efficacy as single agents. This trial evaluates efficacy of a gabapentin-rofecoxib combination following hysterectomy. In addition to IV-PCA...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2004.10.008
更新日期:2005-01-01 00:00:00
abstract::Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.0000000000000002
更新日期:2015-01-01 00:00:00
abstract::In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spont...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90055-T
更新日期:1993-04-01 00:00:00
abstract::Anxiety has been described as an important comorbidity in patients suffering from chronic pain. However, in animals the connection between persistent pain and anxiety has hardly been investigated. Therefore, in the current study it was assessed whether chronic pain also causes anxiety-like behaviour in animals and if ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.05.003
更新日期:2008-10-15 00:00:00
abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91121-X
更新日期:1990-03-01 00:00:00
abstract::The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90078-C
更新日期:1991-08-01 00:00:00
abstract::Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervent...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.07.006
更新日期:2010-10-01 00:00:00
abstract::Existing estimates of sociodemographic disparities in chronic pain in the United States are based on cross-sectional data, often treat pain as a binary construct, and rarely test for nonresponse or other types of bias. This study uses 7 biennial waves of national data from the Health and Retirement Study (1998-2010; n...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000762
更新日期:2017-02-01 00:00:00
abstract::Substance P (SP) plays a central role in the transduction of second messenger signals from primary afferent nociceptive terminals to second-order neurons in the spinal cord. We have tested a recombinant engineered diphtheria toxin/SP fusion protein (DAB389SP) in acute and chronic pain models in the rat. DAB389SP binds...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00170-5
更新日期:1999-02-01 00:00:00
abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(99)00259-6
更新日期:2000-03-01 00:00:00
abstract::A survey of the psychological characteristics of a large sample of chronic headache cases (n = 360), including classical and common migraine and tension headache sufferers, was carried out. Comparing groups defined in terms of the chronicity of their headache problems, it was found that those with a longer history of ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90286-6
更新日期:1985-02-01 00:00:00
abstract::In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pai...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(87)90016-9
更新日期:1987-09-01 00:00:00
abstract::A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90023-7
更新日期:1989-02-01 00:00:00
abstract::The discTRODE probe applies radiofrequency (RF) current, heating the annulus to treat chronic discogenic low back pain. Randomized controlled studies have not been published. We assessed the long-term effect and safety aspects of percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) with the discTRODE prob...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2009.05.001
更新日期:2009-10-01 00:00:00
abstract::Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00324-x
更新日期:2003-01-01 00:00:00
abstract::Somatovisceral convergence was demonstrated in recordings from 15 of 16 spinothalamic tract cells in the lower thoracic spinal cords of anesthetized monkeys. Inputs were produced by mechanical (or sometimes electrical) stimulation of the skin over the lower trunk and by electrical stimulation of the greater splanchnic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90002-6
更新日期:1981-10-01 00:00:00
abstract::Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00264-6
更新日期:2002-11-01 00:00:00
abstract::The effects of lateral reticular nucleus (LRN) stimulation on the responses to tooth pulp (TP) stimulation of neurons located in the trigeminal (V) sensory (39 units) and motor (33 units) nuclei were assessed in anesthetized rats. Only neurons which responded to TP stimulation with bursts of spikes that were in a cons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90035-V
更新日期:1991-07-01 00:00:00
abstract::We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000352
更新日期:2016-01-01 00:00:00
abstract::Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-la...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001610
更新日期:2019-10-01 00:00:00
abstract::Osteoarthritis (OA) is a debilitating disease in which primarily weight-bearing joints undergo progressive degeneration. Despite the widespread prevalence of OA in the adult population, very little is known about the factors responsible for the generation and maintenance of OA pain. Vasoactive intestinal peptide (VIP)...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.02.015
更新日期:2006-07-01 00:00:00
abstract::Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important ad...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001375
更新日期:2018-12-01 00:00:00
abstract::Although several studies have shown that spouses of chronic pain patients may experience clinically significant depressive symptoms few studies have comprehensively examined the role of both patient and spouse-related factors in the development and maintenance of this emotional distress. Twenty-nine married male chron...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90148-Q
更新日期:1991-01-01 00:00:00
abstract::Recent studies showed an enhanced general sensitivity to painful stimuli in adult migraineurs during as well as between attacks. Yet, the influence of a prolonged pain history and potential sex differences has not been studied. We used quantitative sensory testing to examine 25 children with migraine between attacks a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.12.015
更新日期:2006-07-01 00:00:00
abstract::Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/j.pain.0000000000000502
更新日期:2016-05-01 00:00:00
abstract::Central poststroke pain (CPSP) is one of the most refractory chronic pain syndromes. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex has been demonstrated to provide moderate pain relief for CPSP. However, the mechanism underlying the pain relief remains unclear. The objective of this s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.04.017
更新日期:2013-08-01 00:00:00
abstract::Growing evidence suggests that leukocyte extravasation is initiated by the interaction of selectins with their ligands; as well as an essential role for P-selectin in the initial recruitment of inflammatory cells to sites of inflammation. In this study, P-selectin-deficient (P-sel-/-) mice were used to test the hypoth...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.06.042
更新日期:2013-10-01 00:00:00
abstract::The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90028-A
更新日期:1992-09-01 00:00:00
abstract::Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00318-9
更新日期:2001-09-01 00:00:00
abstract::Women with chronic pelvic pain experience serious distress and lifestyle disruption. Confronted with a difficult condition to diagnose and treat effectively, doctors express a negative perception of this group of 'heartsink' patients. This study aimed to characterise medical attitudes towards the treatment of women wi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00104-3
更新日期:1998-08-01 00:00:00