Medullary on- and off-cell responses precede both segmental and thalamic responses to tail heating.

Abstract:

:Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In turn, EMG activation preceded visible tail flick by about 0.09 sec. In 13 other animals ventrobasal thalamic unitary responses were recorded simultaneously with on- and off-cell responses. On-cell bursts or off-cell pauses always preceded thalamic responses by about 0.4 sec. These results support the notion that on- and off-cells play a regulatory role in both segmental and ascending nociceptive transmission.

journal_name

Pain

journal_title

Pain

authors

Hernández N,López Y,Vanegas H

doi

10.1016/0304-3959(89)90009-2

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

221-230

issue

2

eissn

0304-3959

issn

1872-6623

pii

00006396-198911000-00009

journal_volume

39

pub_type

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