Abstract:
:In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spontaneously hypertensive-stroke prone (SH-SP) and Wistar-Kyoto (WKY) rats. The antinociceptive effect of clonidine, measured by the hot plate method, was greater in the hypertensive rats (SH-SP) than in their normotensive controls (WKY). The enhancement of clonidine-induced antinociception in these genetically hypertensive rats was not altered after acute lowering of blood pressure with guanethidine. Furthermore, the development of this hyper-antinociceptive effect of clonidine was earlier than that of hypertension in SH rats. In conclusion, our data suggest that the enhanced antinociceptive effect of clonidine in hypertensive animals is not directly related to blood pressure.
journal_name
Painjournal_title
Painauthors
Lin JC,Tsao WL,Lee HK,Wang Ydoi
10.1016/0304-3959(93)90055-Tsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
53-58issue
1eissn
0304-3959issn
1872-6623pii
00006396-199304000-00008journal_volume
53pub_type
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