P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice.

abstract：:We performed a prospective study in 32 patients with Guillain-Barré syndrome (GBS) or its variants to correlate intraepidermal nerve fiber density (IENFD) at the distal leg and lumbar region with pain, autonomic dysfunction, and outcome. In the acute phase, IENFD was reduced in 60% and 61.9% of patients at the distal ...

journal_title：Pain

authors： Ruts L,van Doorn PA,Lombardi R,Haasdijk ED,Penza P,Tulen JHM,Hempel RJ,van den Meiracker AH,Lauria G

更新日期：2012-02-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...

journal_title：Pain

authors： Bannister K,Patel R,Goncalves L,Townson L,Dickenson AH

更新日期：2015-09-01 00:00:00

abstract：:Aiming at developing a new, noninvasive approach to spinal cord neuromodulation, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in the central pain pathways in human beings. A double-blind crossover design was used to investigate the effects of anodal direct current (2...

journal_title：Pain

authors： Cogiamanian F,Vergari M,Schiaffi E,Marceglia S,Ardolino G,Barbieri S,Priori A

更新日期：2011-02-01 00:00:00

abstract：:This study determined whether opiates alter vascular components of inflammation (hyperthermia, edema and plasma extravasation) in addition to the suppression of hyperalgesia. Rats were administered carrageenan into one hind paw and saline into the other hind paw, followed by i.p. injection of morphine (0.2-5.0 mg/kg) ...

journal_title：Pain

authors： Joris J,Costello A,Dubner R,Hargreaves KM

更新日期：1990-10-01 00:00:00

abstract：:Movement is changed in pain, but the mechanisms remain unclear. Key questions are unresolved such as whether activation can be inhomogeneously distributed within a muscle in a manner that is specific to the location of noxious input. This study addressed this question using high-density electromyography (EMG) to study...

journal_title：Pain

authors： Gallina A,Salomoni SE,Hall LM,Tucker K,Garland SJ,Hodges PW

更新日期：2018-11-01 00:00:00

abstract：:Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...

journal_title：Pain

authors： Kamerman PR,Bradshaw D,Laubscher R,Pillay-van Wyk V,Gray GE,Mitchell D,Chetty S

更新日期：2020-07-01 00:00:00

abstract：:Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...

journal_title：Pain

authors： Chaturvedi SK

更新日期：1987-05-01 00:00:00

abstract：:These experiments quantitatively analyzed effects of electrical midbrain stimulation on a nociceptive hind limb flexion reflex in rats anesthetized with sodium pentobarbital. We recorded the force of isometric hind limb flexion withdrawal, and related flexor electromyographic (EMG) activity, elicited by noxious heat (...

journal_title：Pain

authors： Carstens E,Campbell IG

更新日期：1988-05-01 00:00:00

abstract：:This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Stud...

journal_title：Pain

authors： Thakral M,Shi L,Foust JB,Patel KV,Shmerling RH,Bean JF,Leveille SG

更新日期：2016-12-01 00:00:00

abstract：:Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...

journal_title：Pain

authors： Baad-Hansen L,Pigg M,Ivanovic SE,Faris H,List T,Drangsholt M,Svensson P

更新日期：2013-08-01 00:00:00

abstract：:Laser evoked potentials (LEPs) are nociceptive-related brain responses to activation of cutaneous nociceptors by laser radiant heat stimuli. We previously showed that LEP amplitude during the P2 period (approximately 400 ms) was increased by rare noxious stimuli, inside and outside the focus of spatial attention. It w...

journal_title：Pain

authors： Legrain V,Bruyer R,Guérit JM,Plaghki L

更新日期：2003-06-01 00:00:00

abstract：:Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...

journal_title：Pain

authors： Ingemar F,Ahlgren H,Ahlgren MBE

更新日期：1987-12-01 00:00:00

abstract：:The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...

journal_title：Pain

authors： Schmidtko A,Del Turco D,Coste O,Ehnert C,Niederberger E,Ruth P,Deller T,Geisslinger G,Tegeder I

更新日期：2005-05-01 00:00:00

abstract：:Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...

journal_title：Pain

authors： Simmons K,Ortiz R,Kossowsky J,Krummenacher P,Grillon C,Pine D,Colloca L

更新日期：2014-11-01 00:00:00

abstract：:The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...

journal_title：Pain

authors： Lefaucheur JP

更新日期：2016-02-01 00:00:00

abstract：:A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...

journal_title：Pain

authors： Dworkin RH,Turk DC,Peirce-Sandner S,Burke LB,Farrar JT,Gilron I,Jensen MP,Katz NP,Raja SN,Rappaport BA,Rowbotham MC,Backonja MM,Baron R,Bellamy N,Bhagwagar Z,Costello A,Cowan P,Fang WC,Hertz S,Jay GW,Junor R,Ker

更新日期：2012-06-01 00:00:00

abstract：:The capsaicin receptor in nociceptive neurons is a target for the sensitizing actions of algogenic inflammatory mediators. Capsaicin and potential endogenous ligands are thought not to gate this heat-activated ion channel but to sensitize it so profoundly that even room temperature can open it. We investigated the tem...

journal_title：Pain

authors： Kichko TI,Reeh PW

更新日期：2004-07-01 00:00:00

abstract：:Treatment of adult rats with a single dose of nerve growth factor (NGF, 1 mg/kg, i.p.) results in a prolonged hypersensitivity to noxious thermal stimulation which becomes noticeable within 30 min of administration and lasts for several days. A significant mechanical hyperalgesia develops within 7 h following injectio...

journal_title：Pain

authors： Rueff A,Dawson AJ,Mendell LM

更新日期：1996-08-01 00:00:00

abstract：:The effects of electrical and chemical stimulation of the arcuate nucleus of the hypothalamus (ARH) on the tail flick latency (TFL) and paw pressure withdrawal threshold (PWT) were investigated in the lightly pentobarbital-anesthetized and acutely prepared rat. Electrical stimulation of the ARH for 20 sec at 8 Hz prod...

journal_title：Pain

authors： Wang Q,Mao L,Han J

更新日期：1990-04-01 00:00:00

abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...

journal_title：Pain

authors： Hardy PAJ,Wells JCD

更新日期：1989-02-01 00:00:00

abstract：:Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mechanisms. As part of the Veterans Integrated Pain Evaluation Rese...

journal_title：Pain

authors： Chamessian A,Van de Ven T,Buchheit T,Hsia HL,McDuffie M,Gamazon ER,Walsh C,Bruehl S,Buckenmaier C' 3rd,Shaw A

更新日期：2017-01-01 00:00:00

abstract：:Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...

journal_title：Pain

authors： Spinella M,Cooper ML,Bodnar RJ

更新日期：1996-03-01 00:00:00

abstract：:Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on...

journal_title：Pain

authors： Salvo E,Campana WM,Scheff NN,Nguyen TH,Jeong SH,Wall I,Wu AK,Zhang S,Kim H,Bhattacharya A,Janal MN,Liu C,Albertson DG,Schmidt BL,Dolan JC,Schmidt RE,Boada MD,Ye Y

更新日期：2020-11-01 00:00:00

abstract：:Pain and thermal sensitivity thresholds in healthy volunteers were examined for diurnal variations. The subjects were 11 men aged between 22 and 27 years (means = 23.5, S.D. = 1.5). Data were collected for 2 days, with 7 measurements per day. To ensure the pain specificity of the results the subliminal modality, i.e.,...

journal_title：Pain

authors： Strian F,Lautenbacher S,Galfe G,Hölzl R

更新日期：1989-01-01 00:00:00

abstract：:A psychophysical investigation was carried out to examine whether heat hyperalgesia exists within the secondary mechanical hyperalgesia zone surrounding a capsaicin injection site on hairy skin. A non-contact laser stimulator was used to deliver temperature controlled stimuli to sites within and outside the zone of me...

journal_title：Pain

authors： Ali Z,Meyer RA,Campbell JN

更新日期：1996-12-01 00:00:00

abstract：:The somatosensory abnormalities in 20 men and 7 women (mean age 67 years, range 53-81) with central post-stroke pain (CPSP) have been analysed in detail with traditional neurological tests and quantitative methods. The cerebrovascular lesions were located in the lower brain-stem in 8 patients, involved the thalamus in...

journal_title：Pain

authors： Boivie J,Leijon G,Johansson I

更新日期：1989-05-01 00:00:00

abstract：:Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS ...

journal_title：Pain

authors： Cui JG,O'Connor WT,Ungerstedt U,Linderoth B,Meyerson BA

更新日期：1997-10-01 00:00:00

abstract：:The present study evaluated the efficacy of a clinician-guided Internet-delivered cognitive behaviour therapy (iCBT) program, the Pain Course, to reduce disability, anxiety, and depression associated with chronic pain. Sixty-three adults with chronic pain were randomised to either a Treatment Group or waitlist Control...

journal_title：Pain

authors： Dear BF,Titov N,Perry KN,Johnston L,Wootton BM,Terides MD,Rapee RM,Hudson JL

更新日期：2013-06-01 00:00:00

abstract：ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...

journal_title：Pain

authors： Solcà M,Krishna V,Young N,Deogaonkar M,Herbelin B,Orepic P,Mange R,Rognini G,Serino A,Rezai A,Blanke O

更新日期：2020-11-30 00:00:00