Determination of mild, moderate, and severe pain interference in patients with cancer.

abstract：:Neuroimaging studies of patients with chronic pain have shown that neurotransmitter abnormalities, including increases in glutamate and decreases in GABA, could be responsible for the cortical hyperactivity and hyperalgesia/allodynia observed in some pain conditions. These finding are particularly evident in the insul...

journal_title：Pain

authors： Watson CJ

更新日期：2016-10-01 00:00:00

abstract：:Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. The results of these studies may be challenged due to methodological problems. We therefore conducted a double-blind, controlled, cross-over study on the effect of acute hyperglycemia on nociceptive and n...

journal_title：Pain

authors： Thye-Rønn P,Sindrup SH,Arendt-Nielsen L,Brennum J,Hother-Nielsen O,Beck-Nielsen H

更新日期：1994-01-01 00:00:00

abstract：:Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in chronic pain remains unclear. The present study comb...

journal_title：Pain

authors： Chu YC,Guan Y,Skinner J,Raja SN,Johns RA,Tao YX

更新日期：2005-12-15 00:00:00

abstract：:Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...

journal_title：Pain

authors： Sugimoto T,Yoshida A,Nishijima K,Ichikawa H

更新日期：1995-10-01 00:00:00

abstract：:A double-blind placebo-controlled crossover trial was used to determine the effects of topical ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on the sensory disturbances in 20 patients with complex regional pain syndrome (CRPS). On two occasions separated by at least one week, sensory tests to light tou...

journal_title：Pain

authors： Finch PM,Knudsen L,Drummond PD

更新日期：2009-11-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:The presence of a trigger point is essential to the myofascial pain syndrome. This study centres on identifying clearer criteria for the presence of trigger points in the quadratus lumborum and gluteus medius muscle by investigating the occurrence and inter-rater reliability of trigger point symptoms. Using the sympto...

journal_title：Pain

authors： Hua NK,Van der Does E

更新日期：1994-09-01 00:00:00

abstract：:The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antag...

journal_title：Pain

authors： Han NL,Luo F,Bian ZP,Han JS

更新日期：2000-04-01 00:00:00

abstract：:The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence t...

journal_title：Pain

authors： Seminowicz DA,de Martino E,Schabrun SM,Graven-Nielsen T

更新日期：2018-12-01 00:00:00

abstract：:The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered. Subjects were provided with high and low levels of information regarding t...

journal_title：Pain

authors： Dworkin SF,Chen ACN,Schubert MM,Clark DW

更新日期：1984-08-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...

journal_title：Pain

authors： Wesselmann U,Lai J

更新日期：1997-12-01 00:00:00

abstract：:The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...

journal_title：Pain

authors： Petersen KL,Brennum J,Dahl JB

更新日期：1997-04-01 00:00:00

abstract：:Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat model of endometriosis. Eight weeks after endometrium transplantation into the inte...

journal_title：Pain

authors： Ge P,Ren J,Harrington AM,Grundy L,Castro J,Brierley SM,Hannig G

更新日期：2019-11-01 00:00:00

abstract：:For many individuals undergoing routine surgical procedures, their satisfaction with the operation may depend upon their postoperative experience. We used the McGill Pain Questionnaire and the McGill Nausea Questionnaire to study the intensity of 5 common postoperative problems--sore throat, muscle pain, headache, bac...

journal_title：Pain

authors： Cohen MM,Tate RB

更新日期：1989-12-01 00:00:00

abstract：:Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...

journal_title：Pain

authors： Gustavsson A,Bjorkman J,Ljungcrantz C,Rhodin A,Rivano-Fischer M,Sjolund FK,Mannheimer C

更新日期：2012-12-01 00:00:00

abstract：:Microvascular decompression (MVD) of cranial nerves has become an established treatment for trigeminal and (vago)glossopharyngeal neuralgia and for hemifacial spasm. The authors present the case of a 64-year-old man who had a 3.5-year history of severe, drug-resistant hemibody pain with sensory and autonomic disturban...

journal_title：Pain

authors： Simpson BA,Amato-Watkins A,Hourihan MD

更新日期：2014-08-01 00:00:00

abstract：:Neuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important to move beyond the sole treatment of pain, to recognize depressive symptoms, and to ultimately improve the quality of life. We systematically searched for published and unpublished c...

journal_title：Pain

authors： Caruso R,Ostuzzi G,Turrini G,Ballette F,Recla E,Dall'Olio R,Croce E,Casoni B,Grassi L,Barbui C

更新日期：2019-10-01 00:00:00

abstract：:Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gen...

journal_title：Pain

authors： Kallenborn-Gerhardt W,Hohmann SW,Syhr KM,Schröder K,Sisignano M,Weigert A,Lorenz JE,Lu R,Brüne B,Brandes RP,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...

journal_title：Pain

authors： Gibson SJ,Helme RD

更新日期：2000-04-01 00:00:00

abstract：:Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...

journal_title：Pain

authors： Elliott K,Hynansky A,Inturrisi CE

更新日期：1994-12-01 00:00:00

abstract：:Electronic diary assessment methods offer the potential to accurately characterize pain and other daily experiences. However, the frequent assessment of experiences over time often results in missing data. It is important to identify systematic reasons for missing data because such a pattern may bias study results and...

journal_title：Pain

authors： Aaron LA,Mancl L,Turner JA,Sawchuk CN,Klein KM

更新日期：2004-06-01 00:00:00

abstract：:Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodyni...

journal_title：Pain

authors： Tsuda M

更新日期：2019-05-01 00:00:00

abstract：:We report a case control study comparing patients attending a pain clinic whose symptoms were not considered medically explained (cases) with those whose symptoms were considered medically explained (controls). Principal comparisons were psychiatric morbidity, medication use, and iatrogenic factors assessed by intervi...

journal_title：Pain

authors： Kouyanou K,Pither CE,Rabe-Hesketh S,Wessely S

更新日期：1998-06-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...

journal_title：Pain

authors： Olivan-Blázquez B,Herrera-Mercadal P,Puebla-Guedea M,Pérez-Yus MC,Andrés E,Fayed N,López-Del-Hoyo Y,Magallon R,Roca M,Garcia-Campayo J

更新日期：2014-12-01 00:00:00

abstract：:The aim of the study was to investigate to what extent cortical hyper-reactivity to visual stimuli is present in upper limb amputees. Five amputees with phantom limb pain (PLP), five amputees without PLP (Non-PLP) and 10 healthy controls (HC) were investigated using a visual oddball paradigm. Two hundred visual stimul...

journal_title：Pain

authors： Karl A,Diers M,Flor H

更新日期：2004-07-01 00:00:00

abstract：:Although several studies have shown that spouses of chronic pain patients may experience clinically significant depressive symptoms few studies have comprehensively examined the role of both patient and spouse-related factors in the development and maintenance of this emotional distress. Twenty-nine married male chron...

journal_title：Pain

authors： Schwartz L,Slater MA,Birchler GR,Atkinson HJ

更新日期：1991-01-01 00:00:00

abstract：:Skin conductance and heart rate measures obtained from subjects previous to, during, and after their performance of the cold pressor task were correlated with their responses to the McGill Pain Questionnaire administered immediately after the completion of the cold pressor task. A reliable relationship between skin co...

journal_title：Pain

authors： Dowling J

更新日期：1982-01-01 00:00:00

abstract：:The cell soma of primary afferent neurons in the dorsal root ganglion (DRG) is assigned by classical neurophysiology the role of a metabolic depot, charged with supporting the peripheral sensory ending, the conducting axon, and the central synaptic terminals. However, certain peculiarities of DRG morphology and physio...

journal_title：Pain

authors： Devor M

更新日期：1999-08-01 00:00:00

abstract：:Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia. Although evoked responses in neuropathic pain models are well characterized, determining the presence of spontaneous pain is more challenging. We determined whether the chronic constriction injury (CCI) mo...

journal_title：Pain

authors： Dalm BD,Reddy CG,Howard MA,Kang S,Brennan TJ

更新日期：2015-12-01 00:00:00

abstract：:Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic...

journal_title：Pain

authors： Wang X,Wang S,Wang W,Duan J,Zhang M,Lv X,Niu C,Tan C,Wu Y,Yang J,Hu S,Xing J

更新日期：2016-10-01 00:00:00