Determination of mild, moderate, and severe pain interference in patients with cancer.


:Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe pain interference assessed by the Brief Pain Inventory (BPI) and describe the prevalence and characteristics of pain-induced functional impairment in patients with cancer. Data were pooled across 3 Phase III pivotal trials. Patient-completed questionnaires included the EuroQol 5 dimensions questionnaire (EQ5D), Functional Assessment of Cancer Therapy-General Measure (FACT-G), and BPI. Optimal cutpoints for categorizing pain interference into 3 levels were derived using analysis of variance, with different cutpoint sets for BPI total interference (BPI-PITS, the average score of all 7 items), activity-related interference (BPI-WAW, the average score of work, general activity, and walking), and mood-related interference (BPI-REM, the average score of relations with others, enjoyment of life, and mood) as independent variables and EQ5D-visual analog scale and total FACT-G score as dependent variables. To validate the cutpoints, we assessed whether interference categories were in concordance with Eastern Cooperative Oncology Group performance status (ECOG-PS) levels. The optimal cutpoints were (2,5) for BPI-PITS, (2,6) for BPI-WAW, and (2,5) for BPI-REM. The mild (<2), moderate (2-5 or 2-6), and severe (>5 or >6) pain interference groups were significantly concordant with ECOG-PS levels (P < 0.0001). We empirically derived patient-reported pain interference categories in relation to clinician-rated performance status. These cutpoints may facilitate the conduct and interpretation of clinical evaluation, symptom epidemiology, and clinical trials.






Shi Q,Mendoza TR,Dueck AC,Ma H,Zhang J,Qian Y,Bhowmik D,Cleeland CS




Has Abstract


2017-06-01 00:00:00














  • Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn.

    abstract::In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I-III. The main limitation has been the difficulty in defining functional populations among the...


    pub_type: 杂志文章


    authors: Polgár E,Sardella TCP,Tiong SYX,Locke S,Watanabe M,Todd AJ

    更新日期:2013-12-01 00:00:00

  • Reasons for missing interviews in the daily electronic assessment of pain, mood, and stress.

    abstract::Electronic diary assessment methods offer the potential to accurately characterize pain and other daily experiences. However, the frequent assessment of experiences over time often results in missing data. It is important to identify systematic reasons for missing data because such a pattern may bias study results and...


    pub_type: 杂志文章


    authors: Aaron LA,Mancl L,Turner JA,Sawchuk CN,Klein KM

    更新日期:2004-06-01 00:00:00

  • Differential utility of medical procedures in the assessment of chronic pain patients.

    abstract::Physicians are frequently called upon to evaluate patients with chronic pain to (1) establish the etiology, (2) determine the extent of impairment and disability, and (3) prescribe treatment. In many cases, there is little agreement as to what evaluation procedures should be used or how to weight and integrate these f...


    pub_type: 杂志文章


    authors: Rudy TE,Turk DC,Brena SF

    更新日期:1988-07-01 00:00:00

  • Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal.

    abstract::Numerous animal studies suggest that acute and chronic exposure to opioids can be associated with the development of hyperalgesia, i.e. an increased sensitivity to noxious stimuli. Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids. A pivotal role in the gene...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Angst MS,Koppert W,Pahl I,Clark DJ,Schmelz M

    更新日期:2003-11-01 00:00:00

  • Depressed and non-depressed chronic pain patients.

    abstract::A comparison between 102 depressed and 101 non-depressed pain patients, identified with the use of DSM-III criteria, showed that depressed patients were more often elderly and employed as compared to non-depressed patients who were significantly more often found to be younger (P less than 0.001) and were students (P l...


    pub_type: 杂志文章


    authors: Chaturvedi SK

    更新日期:1987-06-01 00:00:00

  • Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy.

    abstract::In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...


    pub_type: 杂志文章


    authors: Treede RD,Cole JD

    更新日期:1993-05-01 00:00:00

  • Manipulating presence influences the magnitude of virtual reality analgesia.

    abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...


    pub_type: 临床试验,杂志文章


    authors: Hoffman HG,Sharar SR,Coda B,Everett JJ,Ciol M,Richards T,Patterson DR

    更新日期:2004-09-01 00:00:00

  • The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study.

    abstract::Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...


    pub_type: 杂志文章


    authors: Basbaum AI,Gautron M,Jazat F,Mayes M,Guilbaud G

    更新日期:1991-12-01 00:00:00

  • Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system.

    abstract::Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP release, but their vasoconstrictor properties limit thei...


    pub_type: 杂志文章


    authors: Labastida-Ramírez A,Rubio-Beltrán E,Haanes KA,Chan KY,Garrelds IM,Johnson KW,Danser AHJ,Villalón CM,MaassenVanDenBrink A

    更新日期:2020-05-01 00:00:00

  • Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.

    abstract::Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort d...


    pub_type: 杂志文章


    authors: Krebs EE,Becker WC,Zerzan J,Bair MJ,McCoy K,Hui S

    更新日期:2011-08-01 00:00:00

  • Pharmacological modulations on the nociceptive flexion reflex in man.

    abstract::Pharmacological actions on the nociceptive flexion flexes of the hindlimb were investigated in 14 normal subjects. These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal recep...


    pub_type: 杂志文章


    authors: Willer JC,Bathien N

    更新日期:1977-04-01 00:00:00

  • NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release.

    abstract::The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura...


    pub_type: 杂志文章


    authors: Juhasz G,Zsombok T,Modos EA,Olajos S,Jakab B,Nemeth J,Szolcsanyi J,Vitrai J,Bagdy G

    更新日期:2003-12-01 00:00:00

  • Percutaneous electrical nerve stimulation: an alternative to TENS in the management of sciatica.

    abstract::Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ghoname EA,White PF,Ahmed HE,Hamza MA,Craig WF,Noe CE

    更新日期:1999-11-01 00:00:00

  • The expression of pain in infants and toddlers: developmental changes in facial action.

    abstract::Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...


    pub_type: 临床试验,杂志文章


    authors: Lilley CM,Craig KD,Grunau RE

    更新日期:1997-08-01 00:00:00

  • The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity.

    abstract::VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...


    pub_type: 杂志文章


    authors: Fairbanks CA,Peterson CD,Speltz RH,Riedl MS,Kitto KF,Dykstra JA,Braun PD,Sadahiro M,Salton SR,Vulchanova L

    更新日期:2014-07-01 00:00:00

  • Development and validation of the Pain Treatment Satisfaction Scale (PTSS): a patient satisfaction questionnaire for use in patients with chronic or acute pain.

    abstract::The purpose of this study was to develop and validate a measure of patient satisfaction for patients receiving treatment for either acute or chronic pain: the Pain Treatment Satisfaction Scale (PTSS). Development of the initial questionnaire included a comprehensive literature review and interviews with patients, phys...


    pub_type: 杂志文章


    authors: Evans CJ,Trudeau E,Mertzanis P,Marquis P,Peña BM,Wong J,Mayne T

    更新日期:2004-12-01 00:00:00

  • Comparison of tenoxicam and bromazepan in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled trial.

    abstract::Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Quijada-Carrera J,Valenzuela-Castaño A,Povedano-Gómez J,Fernández-Rodriguez A,Hernánz-Mediano W,Gutierrez-Rubio A,de la Iglesia-Salgado JL,García-López A

    更新日期:1996-05-01 00:00:00

  • Disproportionate longer-term opioid use among U.S. adults with mood disorders.

    abstract::Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...


    pub_type: 杂志文章


    authors: Halbert BT,Davis RB,Wee CC

    更新日期:2016-11-01 00:00:00

  • Oral mucosal blood flow in patients with burning mouth syndrome.

    abstract::The pathophysiology of burning mouth syndrome (BMS) is largely unknown. Thus, the aim was to study oral mucosal blood flow in BMS-patients using laser Doppler flowmetry (LDF). Thirteen BMS patients (11 female, two male; mean age+/-SD 64.3+/-7.9 years, mean disease duration 18.9+/-6.2 months) and 13 healthy non-smoking...


    pub_type: 杂志文章


    authors: Heckmann SM,Heckmann JG,HiIz MJ,Popp M,Marthol H,Neundörfer B,Hummel T

    更新日期:2001-02-15 00:00:00

  • Intrathecal tri-cyclic antidepressants produce spinal anesthesia.

    abstract::Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...


    pub_type: 杂志文章


    authors: Chen YW,Huang KL,Liu SY,Tzeng JI,Chu KS,Lin MT,Wang JJ

    更新日期:2004-11-01 00:00:00

  • Treatment of chronic neuropathic pain: purine receptor modulation.

    abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...


    pub_type: 杂志文章


    authors: Jacobson KA,Giancotti LA,Lauro F,Mufti F,Salvemini D

    更新日期:2020-07-01 00:00:00

  • Nociceptive nerve activity in an experimental model of knee joint osteoarthritis of the guinea pig: effect of intra-articular hyaluronan application.

    abstract::Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...


    pub_type: 杂志文章


    authors: Gomis A,Miralles A,Schmidt RF,Belmonte C

    更新日期:2007-07-01 00:00:00

  • Plasma and saliva substance P levels: the effects of acute pain in pregnant and non-pregnant women.

    abstract::Substance P like immunoreactivity (SPLI) and total protein (TP) concentrations in plasma and saliva were measured in 80 healthy female patients divided into the following four groups: women in group 1 were not pregnant and they were awaiting tubal ligation; women in group 2 were not pregnant but they experienced acute...


    pub_type: 临床试验,杂志文章


    authors: Dalby PL,Ramanathan S,Rudy TE,Roy L,Amenta JS,Aber A

    更新日期:1997-02-01 00:00:00

  • Health locus of control, gender differences and adjustment to persistent pain.

    abstract::Locus of control (LOC) beliefs, long thought important in adjustment to persistent pain, were studied among 160 subjects (67 males and 93 females) referred to a comprehensive pain rehabilitation program. The subscale structure of the Multidimensional Health Locus of Control (MHLC) was factorially replicated in our sam...


    pub_type: 杂志文章


    authors: Buckelew SP,Shutty MS Jr,Hewett J,Landon T,Morrow K,Frank RG

    更新日期:1990-09-01 00:00:00

  • The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons.

    abstract::The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...


    pub_type: 杂志文章


    authors: Paleček J,Palečková V,Dougherty PM,Willis WD

    更新日期:1994-03-01 00:00:00

  • Fatiguing exercise enhances hyperalgesia to muscle inflammation.

    abstract::Since many people with chronic fatigue present with pain and many people with chronic pain present with fatigue, we tested if fatigue would enhance the response to pain in male and female mice. We further tested for the activation of brainstem nuclei by the fatigue task using c-fos as a marker. Fatigue was induced by ...


    pub_type: 杂志文章


    authors: Sluka KA,Rasmussen LA

    更新日期:2010-02-01 00:00:00

  • Impairment of pain inhibition in chronic tension-type headache.

    abstract::Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...


    pub_type: 杂志文章


    authors: Pielsticker A,Haag G,Zaudig M,Lautenbacher S

    更新日期:2005-11-01 00:00:00

  • Risk factors for neck pain: a longitudinal study in the general population.

    abstract::The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...


    pub_type: 杂志文章


    authors: Croft PR,Lewis M,Papageorgiou AC,Thomas E,Jayson MIV,Macfarlane GJ,Silman AJ

    更新日期:2001-09-01 00:00:00

  • Differential effects of left/right neuropathy on rats' anxiety and cognitive behavior.

    abstract::Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from corti...


    pub_type: 杂志文章


    authors: Leite-Almeida H,Cerqueira JJ,Wei H,Ribeiro-Costa N,Anjos-Martins H,Sousa N,Pertovaara A,Almeida A

    更新日期:2012-11-01 00:00:00

  • Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye.

    abstract::Chronic dry eye disease (DE) is associated with an unstable tear film and symptoms of ocular discomfort. The characteristics of symptoms suggest a key role for central neural processing; however, little is known about central neuroplasticity and DE. We used a model for tear deficient DE and assessed effects on eye bli...


    pub_type: 杂志文章


    authors: Rahman M,Okamoto K,Thompson R,Katagiri A,Bereiter DA

    更新日期:2015-05-01 00:00:00