Disruption and restoration of dorsal horn sensory map after peripheral nerve crush and regeneration.


:Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in almost complete elimination of stimulation-induced fos-neurons in the tibial territory (medial 1/2 of the sciatic territory). When the animals had been conditioned by crushing the tibial nerve 2 weeks before stimulation (11 or 12 days before transection), the number of fos-neurons significantly increased compared to simple transection alone. The increase (2.5-fold) was greatest in the tibial territory. Therefore, the dorsal horn neurons in the deafferented tibial territory exhibited hypersensitivity to intact peroneal primary input, and the somatotopy map was disrupted. When the nerve had been crushed 3 weeks (18 or 19 days earlier than transection) rather than 2 weeks before stimulation, however, the number and distribution of fos-neurons were not different from those without conditioning (transection alone). Regenerated tibial nerve fibers were capable of transganglionic transport of WGA-HRP from the hindpaw receptive field to the tibial territory of the dorsal horn by 3 weeks but not by 2 weeks following the nerve crush. When transection was omitted, noxious signal transmitted through the tibial nerve fibers regenerated by 3 weeks after crush was capable of inducing c-fos in the tibial territory. The injury-induced hypersensitivity of dorsal horn neurons and resulting disruption of somatotopy map were reversed by re-establishment of peripheral tissue-nerve interaction.






Sugimoto T,Yoshida A,Nishijima K,Ichikawa H




Has Abstract


1995-10-01 00:00:00
















  • Memory and pain: tests of mood congruity and state dependent learning in experimentally induced and clinical pain.

    abstract::The associative network theory of memory [2] is outlined along with the concepts of mood congruity and state dependent learning. Two experiments are reported which investigate the occurrence of these effects where memory for pain is concerned. In experiment 1 the performance of 25 chronic pain patients was compared wi...


    pub_type: 杂志文章


    authors: Pearce SA,Isherwood S,Hrouda D,Richardson PH,Erskine A,Skinner J

    更新日期:1990-11-01 00:00:00

  • Brief preoperative mind-body therapies for total joint arthroplasty patients: a randomized controlled trial.

    abstract:ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...


    pub_type: 杂志文章


    authors: Hanley AW,Gililland J,Erickson J,Pelt C,Peters C,Rojas J,Garland EL

    更新日期:2021-01-12 00:00:00

  • Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain.

    abstract::Although pains arising from the craniofacial complex can be severe and debilitating, relatively little is known about the peripheral and central mechanisms that generate and maintain orofacial pain. To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stim...


    pub_type: 杂志文章


    authors: Sabino MA,Honore P,Rogers SD,Mach DB,Luger NM,Mantyh PW

    更新日期:2002-01-01 00:00:00

  • Acute pain in herpes zoster: the famciclovir database project.

    abstract::The results of a considerable number of recent prospective studies have demonstrated that greater acute pain severity in herpes zoster patients is associated with a significantly greater risk of developing postherpetic neuralgia (PHN). Only a few studies have examined the relationships between acute pain severity and ...


    pub_type: 杂志文章,meta分析


    authors: Dworkin RH,Nagasako EM,Johnson RW,Griffin DRJ

    更新日期:2001-10-01 00:00:00

  • A meta-analytic review of pain perception across the menstrual cycle.

    abstract::The purpose of this article is to review the sixteen published studies that examine associations between the perception of experimentally induced pain across menstrual cycle phases of healthy females. We also performed a meta-analysis to quantitatively analyze the data and attempt to draw conclusions. The results sugg...


    pub_type: 杂志文章,meta分析


    authors: Riley JL 3rd,Robinson ME,Wise EA,Price D

    更新日期:1999-06-01 00:00:00

  • Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain.

    abstract::Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Leung A,Wallace MS,Ridgeway B,Yaksh T

    更新日期:2001-03-01 00:00:00

  • A comparison of the effect of attention training and relaxation on responses to pain.

    abstract::This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...


    pub_type: 杂志文章,随机对照试验


    authors: Sharpe L,Perry NK,Rogers P,Dear BF,Nicholas MK,Refshauge K

    更新日期:2010-09-01 00:00:00

  • Comparing the DN4 tool with the IASP grading system for chronic neuropathic pain screening after breast tumor resection with and without paravertebral blocks: a prospective 6-month validation study.

    abstract::Investigating protective strategies against chronic neuropathic pain (CNP) after breast cancer surgery entails using valid screening tools. The DN4 (Douleur Neuropathique en 4 questions) is 1 tool that offers important research advantages. This prospective 6-month follow-up study seeks to validate the DN4 and assess i...


    pub_type: 杂志文章,随机对照试验


    authors: Abdallah FW,Morgan PJ,Cil T,Escallon JM,Semple JL,Chan VW

    更新日期:2015-04-01 00:00:00

  • Comparison of cognitive-behavioral group treatment and an alternative non-psychological treatment for chronic low back pain.

    abstract::This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...


    pub_type: 杂志文章


    authors: Nicholas MK,Wilson PH,Goyen J

    更新日期:1992-03-01 00:00:00

  • An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia.

    abstract::Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precise cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test the...


    pub_type: 杂志文章


    authors: Thomaidou MA,Veldhuijzen DS,Meulders A,Evers AWM

    更新日期:2021-01-01 00:00:00

  • Pain as a predictor of frailty over time among older Mexican Americans.

    abstract::The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epide...


    pub_type: 杂志文章


    authors: Sodhi JK,Karmarkar A,Raji M,Markides KS,Ottenbacher KJ,Al Snih S

    更新日期:2020-01-01 00:00:00

  • Cortical neurostimulation for neuropathic pain: state of the art and perspectives.

    abstract::The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...


    pub_type: 杂志文章,评审


    authors: Lefaucheur JP

    更新日期:2016-02-01 00:00:00

  • Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.

    abstract::Intrathecal administration of serotonin type 2 (5-HT(2)) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antial...


    pub_type: 杂志文章


    authors: Obata H,Saito S,Sakurazawa S,Sasaki M,Usui T,Goto F

    更新日期:2004-03-01 00:00:00

  • Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice.

    abstract::Orexins are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus, and related to the central control of appetite, arousal, and antinociception. Orexin neurons projected to the tuberomammillary nucleus and orexins may release histamine from the histamine neurons in this nucleus. Histamine i...


    pub_type: 杂志文章


    authors: Mobarakeh JI,Takahashi K,Sakurada S,Nishino S,Watanabe H,Kato M,Naghdi N,Yanai K

    更新日期:2005-11-01 00:00:00

  • The use of topical guanethidine in the relief of dentine hypersensitivity: a controlled study.

    abstract::After a pilot study had indicated that the topical application of guanethidine might be of value in the treatment of tooth dentine hypersensitivity, a double-blind study was undertaken to investigate whether guanethidine was more effective than a distilled water control in alleviating dentinal pain. In 39 adult subjec...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dunne SM,Hannington-Kiff JG

    更新日期:1993-08-01 00:00:00

  • Extrasegmental transcutaneous electrical nerve stimulation and mechanical vibratory stimulation as compared to placebo for the relief of acute oro-facial pain.

    abstract::The present paper describes the pain reducing effect of high and low frequency transcutaneous electrical nerve stimulation (TENS) and 100 Hz mechanical vibratory stimulation as compared to placebo stimulation of the HoKu point in 50 patients suffering acute oro-facial pain. Ten of the 30 patients receiving actual stim...


    pub_type: 临床试验,杂志文章


    authors: Ekblom A,Hansson P

    更新日期:1985-11-01 00:00:00

  • The analgesic effect of transcutaneous electrical nerve stimulation (TNS) in patients with rheumatoid arthritis. A comparative study of different pulse patterns.

    abstract::Transcutaneous electrical nerve stimulation (TNS) was used on 20 patients with severe wrist pain due to rheumatoid arthritis. Three different stimulation frequencies were used: high 70 Hz stimulation (70 TNS), low frequency 3 Hz stimulation (3 TNS) and brief trains of stimuli with an internal frequency of 70 Hz and wi...


    pub_type: 杂志文章


    authors: Mannheimer C,Carlsson CA

    更新日期:1979-06-01 00:00:00

  • Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis.

    abstract::The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin. Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin. Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP...


    pub_type: 杂志文章


    authors: Granovsky Y,Matre D,Sokolik A,Lorenz J,Casey KL

    更新日期:2005-06-01 00:00:00

  • Personalized evaluation of self-hypnosis as a treatment of chronic pain: a repertory grid analysis.

    abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...


    pub_type: 杂志文章


    authors: Large RG,James FR

    更新日期:1988-11-01 00:00:00

  • Function-limiting dysesthetic pain syndrome among traumatic spinal cord injury patients: a cross-sectional study.

    abstract::Diffuse burning dysesthetic sensations distal to the level of spinal injury are the most common and disabling painful sequelae of traumatic spinal cord injury (SCI). In a cross-sectional study of 19 SCI patients, clinical characteristics and results of 3 validated pain measurement instruments (McGill Pain Questionnair...


    pub_type: 杂志文章


    authors: Davidoff G,Roth E,Guarracini M,Sliwa J,Yarkony G

    更新日期:1987-04-01 00:00:00

  • Differential neurophysiological correlates of bottom-up and top-down modulations of pain.

    abstract::The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...


    pub_type: 杂志文章,随机对照试验


    authors: Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

    更新日期:2015-02-01 00:00:00

  • Evaluating the efficacy of an attention modification program for patients with fibromyalgia: a randomized controlled trial.

    abstract::Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...


    pub_type: 杂志文章


    authors: Carleton RN,Asmundson GJG,Korol SL,LeBouthillier DM,Hozempa K,Katz JD,Vlaeyen JWS,Crombez G

    更新日期:2020-03-01 00:00:00

  • 'Balanced analgesia' in the perioperative period: is there a place for ketamine?

    abstract::We investigated whether intraoperative 'subanesthetic doses' of ketamine have a postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of administration, either systemic (intravenous, i.v.) or epidural. One hundred patients scheduled for rectal adenocarcinoma surgery under combined...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: De Kock M,Lavand'homme P,Waterloos H

    更新日期:2001-06-01 00:00:00

  • Anti-nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain.

    abstract::Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...


    pub_type: 杂志文章


    authors: Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

    更新日期:2018-11-01 00:00:00

  • Dissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy.

    abstract::In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...


    pub_type: 杂志文章


    authors: Treede RD,Cole JD

    更新日期:1993-05-01 00:00:00

  • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.

    abstract::Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...


    pub_type: 杂志文章


    authors: Zhuang ZY,Gerner P,Woolf CJ,Ji RR

    更新日期:2005-03-01 00:00:00

  • Preprotachykinin A is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli.

    abstract::The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...


    pub_type: 杂志文章


    authors: Gutierrez-Mecinas M,Bell AM,Marin A,Taylor R,Boyle KA,Furuta T,Watanabe M,Polgár E,Todd AJ

    更新日期:2017-03-01 00:00:00

  • Physiological evidence that the 'interphase' in the formalin test is due to active inhibition.

    abstract::Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...


    pub_type: 杂志文章


    authors: Henry JL,Yashpal K,Pitcher GM,Coderre TJ

    更新日期:1999-07-01 00:00:00

  • Empathy hurts: compassion for another increases both sensory and affective components of pain perception.

    abstract::Recent studies demonstrate that some brain structures activated by pain are also engaged when an individual observes someone else in pain, and that these empathy-related responses are modulated as a function of the affective link between the empath and the individual in pain. In this study we test the hypothesis that ...


    pub_type: 杂志文章


    authors: Loggia ML,Mogil JS,Bushnell MC

    更新日期:2008-05-01 00:00:00

  • Intraoral somatosensory abnormalities in patients with atypical odontalgia--a controlled multicenter quantitative sensory testing study.

    abstract::Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...


    pub_type: 杂志文章,多中心研究


    authors: Baad-Hansen L,Pigg M,Ivanovic SE,Faris H,List T,Drangsholt M,Svensson P

    更新日期:2013-08-01 00:00:00