Disruption and restoration of dorsal horn sensory map after peripheral nerve crush and regeneration.


:Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in almost complete elimination of stimulation-induced fos-neurons in the tibial territory (medial 1/2 of the sciatic territory). When the animals had been conditioned by crushing the tibial nerve 2 weeks before stimulation (11 or 12 days before transection), the number of fos-neurons significantly increased compared to simple transection alone. The increase (2.5-fold) was greatest in the tibial territory. Therefore, the dorsal horn neurons in the deafferented tibial territory exhibited hypersensitivity to intact peroneal primary input, and the somatotopy map was disrupted. When the nerve had been crushed 3 weeks (18 or 19 days earlier than transection) rather than 2 weeks before stimulation, however, the number and distribution of fos-neurons were not different from those without conditioning (transection alone). Regenerated tibial nerve fibers were capable of transganglionic transport of WGA-HRP from the hindpaw receptive field to the tibial territory of the dorsal horn by 3 weeks but not by 2 weeks following the nerve crush. When transection was omitted, noxious signal transmitted through the tibial nerve fibers regenerated by 3 weeks after crush was capable of inducing c-fos in the tibial territory. The injury-induced hypersensitivity of dorsal horn neurons and resulting disruption of somatotopy map were reversed by re-establishment of peripheral tissue-nerve interaction.






Sugimoto T,Yoshida A,Nishijima K,Ichikawa H




Has Abstract


1995-10-01 00:00:00
















  • Hypnotic analgesia reduces R-III nociceptive reflex: further evidence concerning the multifactorial nature of hypnotic analgesia.

    abstract::Mechanisms of hypnotic analgesia were investigated by examining changes in the R-III, a nociceptive spinal reflex, during hypnotic reduction of pain sensation and unpleasantness. The R-III was measured in 15 healthy volunteers who gave VAS-sensory and VAS-affective ratings of an electrical stimulus during conditions o...


    pub_type: 杂志文章


    authors: Kiernan BD,Dane JR,Phillips LH,Price DD

    更新日期:1995-01-01 00:00:00

  • Why cooling is beneficial: non-linear temperature-dependency of stimulated iCGRP release from isolated rat skin.

    abstract::The capsaicin receptor in nociceptive neurons is a target for the sensitizing actions of algogenic inflammatory mediators. Capsaicin and potential endogenous ligands are thought not to gate this heat-activated ion channel but to sensitize it so profoundly that even room temperature can open it. We investigated the tem...


    pub_type: 杂志文章


    authors: Kichko TI,Reeh PW

    更新日期:2004-07-01 00:00:00

  • Sensory and autonomic measurements in idiopathic trigeminal neuralgia before and after radiofrequency thermocoagulation: differentiation from some other causes of facial pain.

    abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...


    pub_type: 杂志文章


    authors: Hampf G,Bowsher D,Wells C,Miles J

    更新日期:1990-03-01 00:00:00

  • Unity vs. diversity of neuropathic pain mechanisms: Allodynia and hyperalgesia in rats selected for heritable predisposition to spontaneous pain.

    abstract::Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in the neuroma model of neuropathic pain (HA rats (high autotomy) and LA ...


    pub_type: 杂志文章


    authors: Ziv-Sefer S,Raber P,Barbash S,Devor M

    更新日期:2009-11-01 00:00:00

  • Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain.

    abstract::We investigated the efficacy of local intraplantar (i.pl.) injection of peptide and non-peptide mu-, delta- and kappa-opioid receptor agonists in rat models of inflammatory and neuropathic pain. Locally applied agonists dose-dependently reduced formalin-induced flinching of the inflamed paw and induced antiallodynic a...


    pub_type: 杂志文章


    authors: Obara I,Parkitna JR,Korostynski M,Makuch W,Kaminska D,Przewlocka B,Przewlocki R

    更新日期:2009-02-01 00:00:00

  • Stability of patient adaptation classifications on the multidimensional pain inventory.

    abstract::This study examined the adaptational classification stability of the multidimensional pain inventory (MPI) in two samples of female fibromyalgia syndrome patients. Retest resulted in one-third of patients being assigned to a different classification. Twenty patients had four repeated MPI assessments over a 10-month pe...


    pub_type: 杂志文章


    authors: Broderick JE,Junghaenel DU,Turk DC

    更新日期:2004-05-01 00:00:00

  • α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement.

    abstract::Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...


    pub_type: 杂志文章


    authors: Di Cesare Mannelli L,Cinci L,Micheli L,Zanardelli M,Pacini A,McIntosh JM,Ghelardini C

    更新日期:2014-10-01 00:00:00

  • Quality indicators to assess quality of pain clinic care from the perspective of patients with chronic pain: development, usability, comprehensibility, and psychometric quality of the QiPPP questionnaire.

    abstract::To address the lack of appropriate patient-defined quality indicators (QIs) for assessment of pain clinic care in the Netherlands, we developed the "Quality Indicators Pain Patients' Perspective" (QiPPP) questionnaire. Quality indicators are widely used to measure the quality of the structure, process, and outcome of ...


    pub_type: 杂志文章


    authors: de Meij N,Köke A,Thomassen I,Kallewaard JW,van Kleef M,van der Weijden T

    更新日期:2018-12-01 00:00:00

  • TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation.

    abstract::Inflammatory thermal hyperalgesia is principally mediated through transient receptor potential vanilloid 1 (TRPV1) channels, as demonstrated by prior studies using models of cutaneous inflammation. Muscle pain is significantly different from cutaneous pain, and the involvement of TRPV1 in hyperalgesia induced by muscl...


    pub_type: 杂志文章


    authors: Walder RY,Radhakrishnan R,Loo L,Rasmussen LA,Mohapatra DP,Wilson SP,Sluka KA

    更新日期:2012-08-01 00:00:00

  • Pain affect in the absence of pain sensation: evidence of asomaesthesia after somatosensory cortex lesions in the rat.

    abstract::Multidimensional models of pain processing distinguish the sensory, motivational, and affective components of the pain experience. Efforts to understand underlying mechanisms have focused on isolating the roles of specific brain structures, including both limbic and non-limbic cortical areas, in the processing of noci...


    pub_type: 杂志文章


    authors: Uhelski ML,Davis MA,Fuchs PN

    更新日期:2012-04-01 00:00:00

  • Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch.

    abstract::Capsaicin-containing plant extracts have been used as topical treatments for a variety of pain syndromes for many centuries. Current products containing capsaicin in low concentrations (usually 0.025-0.075% w/w) have shown efficacy against a variety of pain conditions in clinical studies. However, in order to produce ...


    pub_type: 杂志文章


    authors: Malmberg AB,Mizisin AP,Calcutt NA,von Stein T,Robbins WR,Bley KR

    更新日期:2004-10-01 00:00:00

  • Pain catastrophizing is related to temporal summation of pain but not temporal summation of the nociceptive flexion reflex.

    abstract::Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...


    pub_type: 杂志文章


    authors: Rhudy JL,Martin SL,Terry EL,France CR,Bartley EJ,DelVentura JL,Kerr KL

    更新日期:2011-04-01 00:00:00

  • Regulation of the second-messenger systems in the rat spinal cord during prolonged peripheral inflammation.

    abstract::Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...


    pub_type: 杂志文章


    authors: Igwe OJ,Li N

    更新日期:1994-07-01 00:00:00

  • Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats.

    abstract::Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be algogenic in both animals and humans. Research focus has been directed towards the P2X(3) receptor, as it is preferentially expressed on nociceptive C-fibers a...


    pub_type: 杂志文章


    authors: Honore P,Kage K,Mikusa J,Watt AT,Johnston JF,Wyatt JR,Faltynek CR,Jarvis MF,Lynch K

    更新日期:2002-09-01 00:00:00

  • The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation.

    abstract::Previous studies indicate that descending modulation of nociception is progressively increased following persistent inflammation. The present study was designed to further examine the role of supraspinal neurons in descending modulation following persistent inflammation. Constant levels of paw withdrawal (PW) and tail...


    pub_type: 杂志文章


    authors: Terayama R,Dubner R,Ren K

    更新日期:2002-05-01 00:00:00

  • Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia.

    abstract::Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...


    pub_type: 杂志文章


    authors: Sorkin LS,Otto M,Baldwin WM 3rd,Vail E,Gillies SD,Handgretinger R,Barfield RC,Yu HM,Yu AL

    更新日期:2010-04-01 00:00:00

  • Anti-nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain.

    abstract::Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...


    pub_type: 杂志文章


    authors: Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

    更新日期:2018-11-01 00:00:00

  • Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects.

    abstract::Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...


    pub_type: 杂志文章


    authors: Lötsch J,Dimova V,Hermens H,Zimmermann M,Geisslinger G,Oertel BG,Ultsch A

    更新日期:2015-03-01 00:00:00

  • Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord.

    abstract::Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...


    pub_type: 杂志文章


    authors: Inquimbert P,Bartels K,Babaniyi OB,Barrett LB,Tegeder I,Scholz J

    更新日期:2012-12-01 00:00:00

  • Neurotransmitter systems involved in placebo and nocebo effects in healthy participants and patients with chronic pain: a systematic review.

    abstract::The investigation of neurotransmitter systems in placebo and nocebo effects has improved our understanding of these phenomena. Yet, most studies involve healthy participants. Because the pain modulatory system may differ in healthy participants and patients with chronic pain, it is important to investigate the evidenc...


    pub_type: 杂志文章


    authors: Skyt I,Lunde SJ,Baastrup C,Svensson P,Jensen TS,Vase L

    更新日期:2020-01-01 00:00:00

  • Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats: prolonged effect related to COX-2 expression impairment.

    abstract::Resveratrol is a natural polyphenol that protects from cancer and cardiovascular diseases. Resveratrol is able to induce apoptotic cell death and it inhibits the cyclooxygenase (COX) cascade. We measured the antinociceptive effect of resveratrol on carrageenan-induced hyperalgesia, prostaglandin-E2 (PGE2) concentratio...


    pub_type: 杂志文章


    authors: Pham-Marcou TA,Beloeil H,Sun X,Gentili M,Yaici D,Benoit G,Benhamou D,Mazoit JX

    更新日期:2008-11-30 00:00:00

  • Menstrual pain is associated with rapid structural alterations in the brain.

    abstract::Dysmenorrhea is the most prevalent gynecological disorder in women of child-bearing age. Dysmenorrhea is associated with central sensitization and functional and structural changes in the brain. Our recent brain morphometry study disclosed that dysmenorrhea is associated with trait-related abnormal gray matter (GM) ch...


    pub_type: 杂志文章


    authors: Tu CH,Niddam DM,Yeh TC,Lirng JF,Cheng CM,Chou CC,Chao HT,Hsieh JC

    更新日期:2013-09-01 00:00:00

  • Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans.

    abstract::Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...


    pub_type: 杂志文章


    authors: Magerl W,Wilk SH,Treede RD

    更新日期:1998-02-01 00:00:00

  • Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain.

    abstract::Although pains arising from the craniofacial complex can be severe and debilitating, relatively little is known about the peripheral and central mechanisms that generate and maintain orofacial pain. To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stim...


    pub_type: 杂志文章


    authors: Sabino MA,Honore P,Rogers SD,Mach DB,Luger NM,Mantyh PW

    更新日期:2002-01-01 00:00:00

  • TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin.

    abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...


    pub_type: 杂志文章


    authors: Heber S,Ciotu CI,Hartner G,Gold-Binder M,Ninidze N,Gleiss A,Kress HG,Fischer MJM

    更新日期:2020-07-01 00:00:00

  • Effects of opioid blockade on the modulation of pain and mood by sweet taste and blood pressure in young adults.

    abstract::Increased blood pressure and sweet taste are often associated with decreased pain sensitivity. Animal research suggests that endogenous opioids are involved in both these relationships. Fifty-eight healthy young adults (36 male, 22 female) participated in two sessions receiving a placebo tablet or 50mg of naltrexone o...


    pub_type: 杂志文章


    authors: Lewkowski MD,Young SN,Ghosh S,Ditto B

    更新日期:2008-03-01 00:00:00

  • Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats.

    abstract::Single units were recorded in dorsal roots or in the sciatic nerve of anaesthetised rats. It was shown by making sections, by stimulation and by collision that some ongoing nerve impulses were originating from the dorsal root ganglia and not from the central or peripheral ends of the axons. In a sample of 2731 intact ...


    pub_type: 杂志文章


    authors: Wall PD,Devor M

    更新日期:1983-12-01 00:00:00

  • Choice of strong analgesic in terminal cancer: diamorphine or morphine?

    abstract::A controlled trial of diamorphine (diacetylmorphine, heroin) and morphine is reported in which the two drugs were administered regularly by mouth in individually determined effective analgesic doses. Elixirs contained cocaine hydrochloride 10 mg/dose; other drugs were prescribed when indicated clinically. 699 patients...


    pub_type: 临床试验,杂志文章


    authors: Twycross RG

    更新日期:1977-04-01 00:00:00

  • Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat.

    abstract::The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...


    pub_type: 杂志文章


    authors: Khandwala H,Hodge E,Loomis CW

    更新日期:1997-09-01 00:00:00

  • Descending analgesia--when the spine echoes what the brain expects.

    abstract::Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...


    pub_type: 杂志文章


    authors: Goffaux P,Redmond WJ,Rainville P,Marchand S

    更新日期:2007-07-01 00:00:00