Abstract:
:Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at matched intervals. Thresholds of the three tissues were measured four times during the course of one menstrual cycle at four sites. Two of the sites were on the abdomen within the uterine viscerotome (abdomen-rectus abdominis, left and right) and two were outside it on the limbs (leg-quadriceps, arm-deltoid). Calculated from the beginning of menstruation (day 0), the menstrual phases studied were menstrual (days 2-6), periovulatory (days 12-16), luteal (days 17-22) and premenstrual (days 25-28). Spontaneous pain associated with menstruation was measured from diary estimates on a VAS scale. Whereas the highest thresholds always occurred in the luteal phase regardless of segmental site or stimulus depth, the lowest thresholds occurred in the periovulatory stage for skin, whereas those for muscle/subcutis occurred perimenstrually. Dysmenorrhea accentuated the impact of menstrual phase. For non-dysmenorrheic women menstrual trends were significant only in abdominal muscle and subcutis, but for dysmenorrheic women the trends were also significant in abdominal skin and in limb muscle and subcutis. Dysmenorrhea also lowered thresholds mainly in muscle and sometimes in subcutis, but never in skin, with the greatest hyperalgesic effects in left abdominis muscle. Abdominal sites were more vulnerable to menstrual influences than limb sites. Muscle thresholds, but not skin or subcutis thresholds, were significantly lower in abdomen than in limbs, particularly in dysmenorrheic women. The amount of abdominal muscle hyperalgesia correlated significantly with the amount of spontaneous menstrual pain. Only minor sex differences were observed for pain thresholds of the arm and leg, but there was a unanimous refusal by men, but not by women, to be tested at abdominal sites. These results indicate that menstrual phase, dysmenorrhea status, segmental site, tissue depth and sex all have unique interacting effects on pain thresholds, thus adding more items to the lengthy and still-growing list of biological factors that enter into an individual's judgment of whether or not a stimulus is painful.
journal_name
Painjournal_title
Painauthors
Giamberardino MA,Berkley KJ,Iezzi S,de Bigontina P,Vecchiet Ldoi
10.1016/s0304-3959(97)03362-9subject
Has Abstractpub_date
1997-06-01 00:00:00pages
187-97issue
2eissn
0304-3959issn
1872-6623pii
S0304395997033629journal_volume
71pub_type
临床试验,杂志文章相关文献
PAIN文献大全abstract::Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001193
更新日期:2018-06-01 00:00:00
abstract::In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90808-X
更新日期:1984-09-01 00:00:00
abstract::Pain is a frequently observed non-motor symptom of patients with Parkinson's disease. In some patients, Parkinson's-related pain responds to dopaminergic treatment. In the present study, we aimed to elucidate whether subthalamic deep brain stimulation has a similar beneficial effect on pain in Parkinson's disease, and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.03.008
更新日期:2013-08-01 00:00:00
abstract::The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000778
更新日期:2017-03-01 00:00:00
abstract::The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90083-0
更新日期:1983-05-01 00:00:00
abstract::Experimental muscle pain was elicited by bolus injection of 0.15 ml of 5% hypertonic saline into the human masseter muscle. The sensory experience was described using 10-cm visual analogue scales (VAS) and the McGill Pain Questionnaires (MPQ) on 10 subjects. Effects of pain on deliberately unilateral mastication were ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(95)00133-6
更新日期:1996-02-01 00:00:00
abstract::Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90180-J
更新日期:1992-04-01 00:00:00
abstract::Primary neuronal cell bodies, whose peripheral axons comprised the cutaneous branch of the mylohyoid nerve or innervated the mandibular molar tooth pulp or the cornea, were labeled with HRP and their cross-sectional area was analyzed. Most of their cell bodies were smaller than 1000 microns2 in cross-sectional area an...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90050-4
更新日期:1988-03-01 00:00:00
abstract::Potential applications of attention bias modification (ABM) for acute and chronic pain patients are investigated. In study 1, 54 acute back pain patients (46 of whom completed the study) were recruited at their initial physiotherapy session and randomised to receive 1 session of ABM or placebo. Patients were followed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.12.014
更新日期:2012-03-01 00:00:00
abstract::The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)03324-6
更新日期:1997-04-01 00:00:00
abstract::Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000587
更新日期:2016-08-01 00:00:00
abstract::This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00448-7
更新日期:2003-05-01 00:00:00
abstract::Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000690
更新日期:2016-12-01 00:00:00
abstract::The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00026-X
更新日期:2002-08-01 00:00:00
abstract::Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2014.09.004
更新日期:2014-12-01 00:00:00
abstract::Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000000304
更新日期:2015-11-01 00:00:00
abstract::The present study is a long-term report on 69 patients undergoing unilateral percutaneous cervical cordotomy for vertebral pain due to neoplastic bone metastases. The pain was unilateral or bilateral and was characterised by a chronic and/or an incident component. Seventy-one per cent (49/69) of the patients benefitte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90832-7
更新日期:1984-06-01 00:00:00
abstract::Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain activity. Here we identify brain regions involved in spontaneous pain of PHN (n=11) and determine its modulation with Lidoderm therapy (patches of 5% lidocaine applied to the PHN affected ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2006.09.014
更新日期:2007-03-01 00:00:00
abstract::The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90083-2
更新日期:1987-07-01 00:00:00
abstract::Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460325.25762.c0
更新日期:2015-03-01 00:00:00
abstract::The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2005.07.002
更新日期:2005-10-01 00:00:00
abstract::A 1-year follow-up of two preadolescent age cohorts with musculoskeletal pain at least once a week was conducted to analyze predictive factors for the persistence of musculoskeletal pain. Of the 564 children with pain at baseline, representing one third of the sample studied, 515 (91.3%) could be followed and 452 (80....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00083-9
更新日期:1998-07-01 00:00:00
abstract::Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We evaluated this plasticity by recording responses to mechanical stimuli in silent neurons (nonspontaneously active [NSA]) and neurons showing on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000538
更新日期:2016-07-01 00:00:00
abstract::Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001146
更新日期:2018-04-01 00:00:00
abstract::Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000114
更新日期:2015-06-01 00:00:00
abstract::We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2006.03.020
更新日期:2006-09-01 00:00:00
abstract::Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460328.10515.c9
更新日期:2015-03-01 00:00:00
abstract::Biopsychosocial models of chronic pain that recognize psychological and environmental factors as important aspects of adjustment to pain have been proposed for understanding chronic pain and related suffering in persons with multiple sclerosis (MS), but such models have not been empirically tested. The objective of th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.07.017
更新日期:2007-01-01 00:00:00
abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91121-X
更新日期:1990-03-01 00:00:00