Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up.

abstract：:Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...

journal_title：Pain

authors： Chaturvedi SK

更新日期：1987-05-01 00:00:00

abstract：:Pain cannot be directly measured in neonates. Therefore, scores based on indirect behavioural signals such as crying, or physiological signs such as blood pressure, are used to quantify neonatal pain both in clinical practice and in clinical studies. The aim of this study was to determine which of the physiological an...

journal_title：Pain

authors： Välitalo PAJ,van Dijk M,Krekels EHJ,Gibbins S,Simons SHP,Tibboel D,Knibbe CAJ

更新日期：2016-08-01 00:00:00

abstract：:Behavioral studies have suggested that placebo analgesia is partly mediated by the endogenous opioid system. Expanding on these results we have shown that the opioid-receptor-rich rostral anterior cingulate cortex (rACC) is activated in both placebo and opioid analgesia. However, there are also differences between the...

journal_title：Pain

authors： Petrovic P,Kalso E,Petersson KM,Andersson J,Fransson P,Ingvar M

更新日期：2010-07-01 00:00:00

abstract：:The significance of preamputation pain for the development of postamputation stump and phantom pain has been discussed over the years and is still a matter of dispute. It has been argued that preamputation pain increases the risk of phantom pain and that phantom pain is a revivification of pain experienced before the ...

journal_title：Pain

authors： Nikolajsen L,Ilkjaer S,Krøner K,Christensen JH,Jensen TS

更新日期：1997-09-01 00:00:00

abstract：:An empirical determination of the nature and minimum number of dimension necessary to describe responses to the McGill Pain Questionnaire, and a comparison of groups, experiencing clinical or experimentally induced pain, on the dimensions were carried out. Eighty-five patients referred to a low back pain diagnostic cl...

journal_title：Pain

authors： Crockett DJ,Prkachin KM,Craig KD

更新日期：1977-12-01 00:00:00

abstract：:In order to clarify the mechanism of reference of pain following cordotomy (ROPC), the authors investigated ROPC in 66 patients undergoing percutaneous cervical cordotomy (PCC) and examined the features of ROPC and the correlation between the occurrence of ROPC and the pre-operative pain states, as well as the results...

journal_title：Pain

authors： Nagaro T,Amakawa K,Kimura S,Arai T

更新日期：1993-05-01 00:00:00

abstract：:The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any p...

journal_title：Pain

authors： Stomp-van den Berg SGM,Hendriksen IJM,Bruinvels DJ,Twisk JWR,van Mechelen W,van Poppel MNM

更新日期：2012-12-01 00:00:00

abstract：:A young female outpatient experienced painful tonic contractions in the right triceps surae muscles as a result of a partial damage of the right peroneal nerve. Electrophysiological recordings of the soleus muscle showed a tonic EMG activity and an hyperexcitability of the monosynaptic H reflex (Hmax/Mmax ratio: 90%)....

journal_title：Pain

authors： Wilier JC

更新日期：1988-03-01 00:00:00

abstract：:Chronic neuropathic pain is associated with long-term changes at multiple levels of the neuroaxis, including in the brain, where electrical stimulation has been used to manage severe pain conditions. However, the clinical outcome of deep brain stimulation is often mixed, and the mechanisms are poorly understood. By me...

journal_title：Pain

authors： Iwata M,LeBlanc BW,Kadasi LM,Zerah ML,Cosgrove RG,Saab CY

更新日期：2011-11-01 00:00:00

abstract：:Cultures differ as to typical linguistic reports and classifications of pain. In some languages upwards of a dozen specific pain terms are in common use, each indicating a particular pain experience. In other languages a single inclusive term is the norm, perhaps with optional qualifiers added to make desired distinct...

journal_title：Pain

authors： Diller A

更新日期：1980-08-01 00:00:00

abstract：:Long-term potentiation (LTP) in wide dynamic range (WDR) neurons in the dorsal horn has been suggested to contribute to central sensitization and the development of chronic pain. Indirect experimental evidence indicates an involvement of substance P (SP), in this respect. The aim of the present study was to monitor th...

journal_title：Pain

authors： Afrah AW,Fiskå A,Gjerstad J,Gustafsson H,Tjølsen A,Olgart L,Stiller CO,Hole K,Brodin E

更新日期：2002-03-01 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be algogenic in both animals and humans. Research focus has been directed towards the P2X(3) receptor, as it is preferentially expressed on nociceptive C-fibers a...

journal_title：Pain

authors： Honore P,Kage K,Mikusa J,Watt AT,Johnston JF,Wyatt JR,Faltynek CR,Jarvis MF,Lynch K

更新日期：2002-09-01 00:00:00

abstract：:The present study was undertaken to investigate the possible involvement of peripheral nociceptors in 3 diagnostic categories of elderly patients with chronic pain. The 3 diagnostic groups consisted of: chronic lower lumbar pain of degenerative musculoskeletal etiology (LLP), post-herpetic neuralgia (PHN) and pain of ...

journal_title：Pain

authors： LeVasseur SA,Gibson SJ,Helme RD

更新日期：1990-04-01 00:00:00

abstract：:The present study is a long-term report on 69 patients undergoing unilateral percutaneous cervical cordotomy for vertebral pain due to neoplastic bone metastases. The pain was unilateral or bilateral and was characterised by a chronic and/or an incident component. Seventy-one per cent (49/69) of the patients benefitte...

journal_title：Pain

authors： Ischia S,Luzzani A,Ischia A,Pacini L

更新日期：1984-06-01 00:00:00

abstract：:The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...

journal_title：Pain

authors： Goossens ME,Vlaeyen JW,Rutten-van Mölken MP,van der Linden SM

更新日期：1999-03-01 00:00:00

abstract：:There are contradictory findings about whether there are differences in personality and/or amount of emotional disturbance between patients with functional versus organic low back pain. The MMPI scores of 42 back pain patients diagnosed as "organic" were compared with the scores of 37 patients classified as "functiona...

journal_title：Pain

authors： McCreary C,Turner J,Dawson E

更新日期：1977-10-01 00:00:00

abstract：:Patients with chronic low back pain (LBP) frequently demonstrate high scores for fear-avoidance beliefs and distress. We need better knowledge about fear-avoidance beliefs and distress in early stages of LBP. The objectives of this study were to compare the level of fear-avoidance beliefs and distress in patients with...

journal_title：Pain

authors： Grotle M,Vøllestad NK,Veierød MB,Brox JI

更新日期：2004-12-01 00:00:00

abstract：:Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...

journal_title：Pain

authors： Wylde V,Lenguerrand E,Gooberman-Hill R,Beswick AD,Marques E,Noble S,Horwood J,Pyke M,Dieppe P,Blom AW

更新日期：2015-06-01 00:00:00

abstract：:Protein kinase signal transduction pathways play critical roles in regulating nociception. Here we show that c-kit, a tyrosine kinase receptor, is expressed in lamina I and II layer of the dorsal horn. Moreover, the superficial c-kit(+) fibers originate from the dorsal root ganglion, and c-kit in lamina II inner layer...

journal_title：Pain

authors： Sun YG,Gracias NG,Drobish JK,Vasko MR,Gereau RW,Chen ZF

更新日期：2009-07-01 00:00:00

abstract：:The effects of electrical and chemical stimulation of the arcuate nucleus of the hypothalamus (ARH) on the tail flick latency (TFL) and paw pressure withdrawal threshold (PWT) were investigated in the lightly pentobarbital-anesthetized and acutely prepared rat. Electrical stimulation of the ARH for 20 sec at 8 Hz prod...

journal_title：Pain

authors： Wang Q,Mao L,Han J

更新日期：1990-04-01 00:00:00

abstract：:Little is known about patients prescribed high doses of opioids to treat chronic non-cancer pain, though these patients may be at higher risk for medication-related complications. We describe the prevalence of high-dose opioid use and associated demographic and clinical characteristics among veterans treated in a VA r...

journal_title：Pain

authors： Morasco BJ,Duckart JP,Carr TP,Deyo RA,Dobscha SK

更新日期：2010-12-01 00:00:00

abstract：:Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....

journal_title：Pain

authors： Martenson ME,Cetas JS,Heinricher MM

更新日期：2009-04-01 00:00:00

abstract：:The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have been strongly implicated in the pathogenesis of neuropathic pain, but the intracellular signaling of these cytokines in glial cells is not fully understood. TNF receptor-associated factor 6 (TRAF6) plays a key role in signal trans...

journal_title：Pain

authors： Lu Y,Jiang BC,Cao DL,Zhang ZJ,Zhang X,Ji RR,Gao YJ

更新日期：2014-12-01 00:00:00

abstract：:The role of prostanoids in nociception is well established. The headache eliciting effects of prostacyclin (prostaglandin I(2), (PGI(2))) and its possible mechanisms had previously not been systematically studied in man. We hypothesized that infusion of PGI(2) might induce headache and vasodilatation of cranial vessel...

journal_title：Pain

authors： Wienecke T,Olesen J,Oturai PS,Ashina M

更新日期：2008-09-30 00:00:00

abstract：:Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...

journal_title：Pain

authors： Jacobson KA,Giancotti LA,Lauro F,Mufti F,Salvemini D

更新日期：2020-07-01 00:00:00

abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...

journal_title：Pain

authors： Inbal R,Rousso M,Ashur H,Wall PD,Devor M

更新日期：1987-02-01 00:00:00

abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...

journal_title：Pain

authors： Mao J,Price DD,Caruso FS,Mayer DJ

更新日期：1996-10-01 00:00:00

abstract：:Chronic pain is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance,...

journal_title：Pain

authors： Ray L,Lipton RB,Zimmerman ME,Katz MJ,Derby CA

更新日期：2011-01-01 00:00:00

abstract：:Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...

journal_title：Pain

authors： Veldman PHJM,Goris JAR

更新日期：1996-03-01 00:00:00

abstract：:The local anesthetic lidocaine was injected into the dentate gyrus (DG) of alert, unrestrained rats 10 min prior to investigation within the formalin test. Regional anesthesia of the DG resulted in a reduction of pain scores when administered contralateral to the site of subcutaneous formalin injection. The analgesic ...

journal_title：Pain

authors： McKenna JE,Melzack R

更新日期：1992-04-01 00:00:00