Abstract:
:The local anesthetic lidocaine was injected into the dentate gyrus (DG) of alert, unrestrained rats 10 min prior to investigation within the formalin test. Regional anesthesia of the DG resulted in a reduction of pain scores when administered contralateral to the site of subcutaneous formalin injection. The analgesic effect was evident 30-50 min after central infusion. These results provide evidence of the involvement of the hippocampal formation (HF) in pain perception.
journal_name
Painjournal_title
Painauthors
McKenna JE,Melzack Rdoi
10.1016/0304-3959(92)90195-Hkeywords:
subject
Has Abstractpub_date
1992-04-01 00:00:00pages
105-112issue
1eissn
0304-3959issn
1872-6623pii
00006396-199204000-00017journal_volume
49pub_type
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