Abstract:
:Pain cannot be directly measured in neonates. Therefore, scores based on indirect behavioural signals such as crying, or physiological signs such as blood pressure, are used to quantify neonatal pain both in clinical practice and in clinical studies. The aim of this study was to determine which of the physiological and behavioural items of 2 validated pain assessment scales (COMFORT and premature infant pain profile) are best able to detect pain during endotracheal and nasal suctioning in ventilated newborns. We analysed a total of 516 PIPP and COMFORT scores from 118 newborns. A graded response model was built to describe the data and item information was calculated for each of the behavioural and physiological items. We found that the graded response model was able to well describe the data, as judged by agreement between the observed data and model simulations. Furthermore, a good agreement was found between the pain estimated by the graded response model and the investigator-assessed visual analogue scale scores (Spearman rho correlation coefficient = 0.80). The information scores for the behavioural items ranged from 1.4 to 27.2 and from 0.0282 to 0.131 for physiological items. In these data with mild to moderate pain levels, behavioural items were vastly more informative of pain and distress than were physiological items. The items that were the most informative of pain are COMFORT items "calmness/agitation," "alertness," and "facial tension."
journal_name
Painjournal_title
Painauthors
Välitalo PAJ,van Dijk M,Krekels EHJ,Gibbins S,Simons SHP,Tibboel D,Knibbe CAJdoi
10.1097/j.pain.0000000000000485subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1611-1617issue
8eissn
0304-3959issn
1872-6623pii
00006396-201608000-00009journal_volume
157pub_type
杂志文章相关文献
PAIN文献大全abstract::Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.02.042
更新日期:2010-09-01 00:00:00
abstract::Eight patients with established lower limb postamputation stump pain were given lumbar intrathecal fentanyl 25 micrograms and lidocaine 70 mg 2 weeks apart in an attempt to better understand the role of peripheral and central mechanisms in this condition. Baseline pain was recorded and then analgetic and side effects ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90064-K
更新日期:1990-02-01 00:00:00
abstract::In rats anaesthetised with Saffan (Glaxovet), inhibition of the tail flick reflex evoked by electrical stimulation in the dorsal periaqueductal grey matter (PAG) was accompanied by an increase in blood pressure, tachycardia, vasodilatation in hind limb muscle, an increase in respiration, pupillodilatation and widening...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90088-0
更新日期:1985-03-01 00:00:00
abstract:ABSTRACT:The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trial...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002046
更新日期:2021-02-01 00:00:00
abstract::While a variety of cultural, psychological and physiological factors contribute to variability in both clinical and experimental contexts, the role of genetic factors in human pain sensitivity is increasingly recognized as an important element. This study was performed to evaluate genetic influences on variability in ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.02.027
更新日期:2004-06-01 00:00:00
abstract::We investigated whether intraoperative 'subanesthetic doses' of ketamine have a postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of administration, either systemic (intravenous, i.v.) or epidural. One hundred patients scheduled for rectal adenocarcinoma surgery under combined...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(01)00278-0
更新日期:2001-06-01 00:00:00
abstract::The aim of this study was to investigate how exercise influenced endogenous pain modulation in healthy controls, shoulder myalgia patients and fibromyalgia (FM) patients. Twenty-one healthy subjects, 20 shoulder myalgia patients and 20 FM patients, all females, participated. They performed standardized static contract...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.06.021
更新日期:2010-10-01 00:00:00
abstract::Transcutaneous electrical nerve stimulation (TNS) was used on 20 patients with severe wrist pain due to rheumatoid arthritis. Three different stimulation frequencies were used: high 70 Hz stimulation (70 TNS), low frequency 3 Hz stimulation (3 TNS) and brief trains of stimuli with an internal frequency of 70 Hz and wi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90051-4
更新日期:1979-06-01 00:00:00
abstract::A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)91074-8
更新日期:1987-08-01 00:00:00
abstract::The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90141-W
更新日期:1992-05-01 00:00:00
abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001848
更新日期:2020-07-01 00:00:00
abstract::Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(96)03057-6
更新日期:1996-08-01 00:00:00
abstract::The present study utilized recently developed diagnostic tests that permit recognition of functional deficits in spine mobility, trunk strength, endurance, coordination, and dynamic lifting capacity. Changes in these tests were compared to changes in psychological functioning (e.g., self-report of pain) as well as to ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90007-2
更新日期:1986-04-01 00:00:00
abstract::We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001609
更新日期:2019-08-01 00:00:00
abstract::These experiments quantitatively analyzed effects of electrical midbrain stimulation on a nociceptive hind limb flexion reflex in rats anesthetized with sodium pentobarbital. We recorded the force of isometric hind limb flexion withdrawal, and related flexor electromyographic (EMG) activity, elicited by noxious heat (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90092-9
更新日期:1988-05-01 00:00:00
abstract::Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. The results of these studies may be challenged due to methodological problems. We therefore conducted a double-blind, controlled, cross-over study on the effect of acute hyperglycemia on nociceptive and n...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)90148-1
更新日期:1994-01-01 00:00:00
abstract::Previous research implicates an endogenous central pain inhibitory mechanism in opiate analgesia, analgesia produced by focal electrical stimulation of the brain, and acupuncture analgesia. This investigation evaluates the possibility that analgesia produced by hypnosis is also mediated by such a mechanism. Results su...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(77)90085-9
更新日期:1977-10-01 00:00:00
abstract::Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2014.08.036
更新日期:2014-11-01 00:00:00
abstract::The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90073-7
更新日期:1991-08-01 00:00:00
abstract::Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(97)03332-0
更新日期:1997-05-01 00:00:00
abstract::Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(98)00201-2
更新日期:1999-03-01 00:00:00
abstract::The clinical effectiveness of locally administered opioids is still under discussion; in particular, the potency of morphine in settings other than intra-articular arthroscopy has been questioned. We developed another pain model, postpartum resection of the fallopian tubes for sterilisation, in which each patient serv...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(98)00157-2
更新日期:1999-01-01 00:00:00
abstract::Involvement of the NMDA receptor system in the transmission of nociceptive information, including the development of central sensitization and a wind-up phenomenon, has increased interest in NMDA-receptor antagonists as antinociceptive drugs. This case report describes the use of an NMDA receptor antagonist 3-(2-carbo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90266-E
更新日期:1992-11-01 00:00:00
abstract::Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.01.024
更新日期:2010-04-01 00:00:00
abstract::The aim of the study was to investigate to what extent cortical hyper-reactivity to visual stimuli is present in upper limb amputees. Five amputees with phantom limb pain (PLP), five amputees without PLP (Non-PLP) and 10 healthy controls (HC) were investigated using a visual oddball paradigm. Two hundred visual stimul...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.03.003
更新日期:2004-07-01 00:00:00
abstract::Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.05.008
更新日期:2008-03-01 00:00:00
abstract::The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001246
更新日期:2018-08-01 00:00:00
abstract::The termination of an unpleasant or painful somatic condition can produce a rewarding sense of relief, even if the stimulus that causes the termination is itself unpleasant or painful under normal circumstances. We aimed to identify central neural mechanisms of pain relief from capsaicin-elicited heat-hyperalgesia by ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.05.020
更新日期:2008-10-15 00:00:00
abstract::This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03254-x
更新日期:1997-01-01 00:00:00
abstract::Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in chronic pain remains unclear. The present study comb...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.09.024
更新日期:2005-12-15 00:00:00