Abstract:
:In rats anaesthetised with Saffan (Glaxovet), inhibition of the tail flick reflex evoked by electrical stimulation in the dorsal periaqueductal grey matter (PAG) was accompanied by an increase in blood pressure, tachycardia, vasodilatation in hind limb muscle, an increase in respiration, pupillodilatation and widening of the palpebral fissure. Stimulation deeper in the PAG and in the tegmentum ventral to it produced analgesia but without this pattern of autonomic changes. The antinociceptive, cardiovascular and respiratory effects of PAG stimulation were abolished by bilateral lesions in the ventrolateral medulla in the area which lies ventromedial to the facial nucleus (i.e., in nucleus paragigantocellularis lateralis, RPGL). Lesions in nucleus raphe magnus (NRM), or bilateral lesions of nucleus reticularis gigantocellularis (RG) and paragigantocellularis (RPG) or a combination of a lesion in RPGL with one in NRM or the contralateral RG or RPG did not block the effects of stimulating in the dorsal PAG. These findings are discussed in relation to the role of the PAG in mediating behavioural responses to stress.
journal_name
Painjournal_title
Painauthors
Lovick TAdoi
10.1016/0304-3959(85)90088-0subject
Has Abstractpub_date
1985-03-01 00:00:00pages
241-252issue
3eissn
0304-3959issn
1872-6623pii
00006396-198503000-00003journal_volume
21pub_type
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