Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

abstract：:Although it is well known that cannabinoids produce antinociception in acute pain models, there is less information on the ability of cannabinoids to alleviate hyperalgesia. In the present study, we determined whether cannabinoids attenuated the development of hyperalgesia produced by intraplantar injection of capsaic...

journal_title：Pain

authors： Li J,Daughters RS,Bullis C,Bengiamin R,Stucky MW,Brennan J,Simone DA

更新日期：1999-05-01 00:00:00

abstract：:To determine the incidence of pain related sexual dysfunction 1 year after inguinal herniorrhaphy and to assess the impact pain has on sexual function. In contrast to the well-described about 10% risk of chronic wound related pain after inguinal herniorrhaphy, chronic genital pain, dysejaculation, and sexual dysfuncti...

journal_title：Pain

authors： Aasvang EK,Møhl B,Bay-Nielsen M,Kehlet H

更新日期：2006-06-01 00:00:00

abstract：:Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...

journal_title：Pain

authors： Wainapel SF

更新日期：1984-04-01 00:00:00

abstract：:Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...

journal_title：Pain

authors： Fredheim OM,Skurtveit S,Handal M,Hjellvik V

更新日期：2019-04-01 00:00:00

abstract：:We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered from a right-sided postcentral stroke. In this patient, we were able to demonstrate (i) a dissociation of discriminative and affective components of pain perception and, for the first time in humans, (ii) t...

journal_title：Pain

authors： Ploner M,Freund HJ,Schnitzler A

更新日期：1999-05-01 00:00:00

abstract：:Procedural pain is associated with poorer neurodevelopment in infants born very preterm (≤ 32 weeks gestational age), however, the etiology is unclear. Animal studies have demonstrated that early environmental stress leads to slower postnatal growth; however, it is unknown whether neonatal pain-related stress affects ...

journal_title：Pain

authors： Vinall J,Miller SP,Chau V,Brummelte S,Synnes AR,Grunau RE

更新日期：2012-07-01 00:00:00

abstract：:Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from pain research units exp...

journal_title：Pain

authors： Vollert J,Attal N,Baron R,Freynhagen R,Haanpää M,Hansson P,Jensen TS,Rice ASC,Segerdahl M,Serra J,Sindrup SH,Tölle TR,Treede RD,Maier C

更新日期：2016-03-01 00:00:00

abstract：:In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spont...

journal_title：Pain

authors： Lin JC,Tsao WL,Lee HK,Wang Y

更新日期：1993-04-01 00:00:00

abstract：:Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...

journal_title：Pain

authors： Southall DM,Michael LR,Vasko RM

更新日期：1998-10-01 00:00:00

abstract：:Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in chronic pain remains unclear. The present study comb...

journal_title：Pain

authors： Chu YC,Guan Y,Skinner J,Raja SN,Johns RA,Tao YX

更新日期：2005-12-15 00:00:00

abstract：:Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...

journal_title：Pain

authors： Forte BL,Slosky LM,Zhang H,Arnold MR,Staatz WD,Hay M,Largent-Milnes TM,Vanderah TW

更新日期：2016-12-01 00:00:00

abstract：:Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. The aim of this study was to test if the β2-agonist terbutaline relieves painful polyneuropathy. The study was a randomized, double-blind, placebo-controlled and active-controlled, 3-way, c...

journal_title：Pain

authors： Gillving M,Demant D,Holbech JV,Gylfadottir SS,Bach FW,Jensen TS,Finnerup NB,Sindrup SH

更新日期：2020-11-06 00:00:00

abstract：:Twenty-six patients with severe pain associated with cancer were entered into a study where they were required to take morphine mixture for 7 days. Prior to this, their morphine dose had been optimised to provide the most favourable balance between pain relief and side effects. After 6 days of taking their optimised m...

journal_title：Pain

authors： Gourlay GK,Plummer JL,Cherry DA

更新日期：1995-06-01 00:00:00

abstract：:Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...

journal_title：Pain

authors： Ghoname EA,White PF,Ahmed HE,Hamza MA,Craig WF,Noe CE

更新日期：1999-11-01 00:00:00

abstract：:The present study evaluated the efficacy of a clinician-guided Internet-delivered cognitive behaviour therapy (iCBT) program, the Pain Course, to reduce disability, anxiety, and depression associated with chronic pain. Sixty-three adults with chronic pain were randomised to either a Treatment Group or waitlist Control...

journal_title：Pain

authors： Dear BF,Titov N,Perry KN,Johnston L,Wootton BM,Terides MD,Rapee RM,Hudson JL

更新日期：2013-06-01 00:00:00

abstract：:We developed a mouse model of cancer pain to investigate its underlying mechanisms. SCC-7, squamous cell carcinoma (SCC) derived from C3H mice, was inoculated subcutaneously into either the plantar region or thigh in male C3H/Hej mice. Heat and mechanical sensitivity as well as spontaneous behavior were measured at th...

journal_title：Pain

authors： Asai H,Ozaki N,Shinoda M,Nagamine K,Tohnai I,Ueda M,Sugiura Y

更新日期：2005-09-01 00:00:00

abstract：:The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...

journal_title：Pain

authors： Khandwala H,Hodge E,Loomis CW

更新日期：1997-09-01 00:00:00

abstract：:Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...

journal_title：Pain

authors： Lötsch J,Dimova V,Hermens H,Zimmermann M,Geisslinger G,Oertel BG,Ultsch A

更新日期：2015-03-01 00:00:00

abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...

journal_title：Pain

authors： Mao J,Price DD,Caruso FS,Mayer DJ

更新日期：1996-10-01 00:00:00

abstract：:Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in somatosensory processing, as exemplified by the importance of spinal dynorphin-expressing neurons for the suppression of mechanical pain and chemical itch. Although it is...

journal_title：Pain

authors： Serafin EK,Chamessian A,Li J,Zhang X,McGann A,Brewer CL,Berta T,Baccei M

更新日期：2019-10-01 00:00:00

abstract：:Despite the presence of pathology in cancer pain, the pain experience in adult cancer patients cannot be totally explained by the extent of such pathology. Unlike chronic benign pain very little research on the role of biobehavioral factors has been conducted to help explain this paradox. The literature on the role of...

journal_title：Pain

authors： Dalton JA,Feuerstein M

更新日期：1988-05-01 00:00:00

abstract：:This research was designed to identify and validate facial expressions of pain occurring in a clinical chronic pain condition. Facial expressions of 28 patients with chronic temporomandibular disorder pain were videotaped during a painful clinical examination procedure and coded using an anatomically based system. Cha...

journal_title：Pain

authors： LeResche L,Dworkin SF

更新日期：1988-10-01 00:00:00

abstract：:The efficacy of psychological treatments emphasising a self-management approach to chronic pain has been demonstrated by substantial empirical research. Nevertheless, high drop-out and relapse rates and low or unsuccessful engagement in self-management pain rehabilitation programs have prompted the suggestion that peo...

journal_title：Pain

authors： Strong J,Westbury K,Smith G,McKenzie I,Ryan W

更新日期：2002-05-01 00:00:00

abstract：:The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...

journal_title：Pain

authors： Lipman JJ,Blumenkopf B,Parris WCV

更新日期：1987-07-01 00:00:00

abstract：:In the present study, Brandtstädter's (1992) distinction between assimilation and accommodation as two fundamental means of coping is applied to the field of chronic pain. Assimilative coping involves active attempts (e.g. instrumental activities, self-corrective actions, compensatory measures) to alter unsatisfactory...

journal_title：Pain

authors： Schmitz U,Saile H,Nilges P

更新日期：1996-09-01 00:00:00

abstract：:Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In t...

journal_title：Pain

authors： Hernández N,López Y,Vanegas H

更新日期：1989-11-01 00:00:00

abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...

journal_title：Pain

authors： Ardid D,Guilbaud G

更新日期：1992-05-01 00:00:00

abstract：:Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception. In this study a mathematical model was developed in order to quantify the relationship between INA and pain. In 5 patients (45 experiments) INA was recorded using electrodes implanted in lower incis...

journal_title：Pain

authors： Fors U,Ahlquist ML,Skagerwall R,Edwall LGA,Haegerstam GAT

更新日期：1984-04-01 00:00:00

abstract：:Altogether 553 children (195 first graders, mean age 6.8 years, and 358 third graders, mean age 8.7 years) participated in the development of a self-report measure to assess the intensity of children's pain. The first step was the derivation, from children's drawings of facial expressions of pain, of 5 sets of 7 schem...

journal_title：Pain

authors： Bieri D,Reeve RA,Champion DG,Addicoat L,Ziegler JB

更新日期：1990-05-01 00:00:00

abstract：:Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...

journal_title：Pain

authors： Harden RN,Maihofner C,Abousaad E,Vatine JJ,Kirsling A,Perez RSGM,Kuroda M,Brunner F,Stanton-Hicks M,Marinus J,van Hilten JJ,Mackey S,Birklein F,Schlereth T,Mailis-Gagnon A,Graciosa J,Connoly SB,Dayanim D,Massey M,Fr

更新日期：2017-08-01 00:00:00