Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia.

abstract：:The pathophysiology of burning mouth syndrome (BMS) is largely unknown. Thus, the aim was to study oral mucosal blood flow in BMS-patients using laser Doppler flowmetry (LDF). Thirteen BMS patients (11 female, two male; mean age+/-SD 64.3+/-7.9 years, mean disease duration 18.9+/-6.2 months) and 13 healthy non-smoking...

journal_title：Pain

authors： Heckmann SM,Heckmann JG,HiIz MJ,Popp M,Marthol H,Neundörfer B,Hummel T

更新日期：2001-02-15 00:00:00

abstract：:Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...

journal_title：Pain

authors： Bernfort L,Gerdle B,Rahmqvist M,Husberg M,Levin LÅ

更新日期：2015-03-01 00:00:00

abstract：:Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...

journal_title：Pain

authors： Keefe FJ,Lefebvre JC,Kerns RD,Rosenberg R,Beaupre P,Prochaska J,Prochaska JO,Caldwell DS

更新日期：2000-09-01 00:00:00

abstract：:Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive inf...

journal_title：Pain

authors： Bingel U,Quante M,Knab R,Bromm B,Weiller C,Büchel C

更新日期：2002-09-01 00:00:00

abstract：:Conditioned pain modulation (CPM) is a phenomenon that may be tested with a dynamic quantitative sensory test that assesses the inhibitory aspect of this pain modulatory network. Although CPM has been adopted as a clinical assessment tool in recent years, the stability of the measure has not been determined over long ...

journal_title：Pain

authors： Wilson H,Carvalho B,Granot M,Landau R

更新日期：2013-12-01 00:00:00

abstract：:The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...

journal_title：Pain

authors： Jones SF,McQuay HJ,Moore RA,Hand CW

更新日期：1988-08-01 00:00:00

abstract：:Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...

journal_title：Pain

authors： Tesarz J,Gerhardt A,Leisner S,Janke S,Treede RD,Eich W

更新日期：2015-04-01 00:00:00

abstract：:The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdo...

journal_title：Pain

authors： Miranda HF,Puig MM,Prieto JC,Pinardi G

更新日期：2006-03-01 00:00:00

abstract：:Although many patients with multiple sclerosis (MS) complain of trigeminal neuralgia (TN), its cause and mechanisms are still debatable. In a multicentre controlled study, we collected 130 patients with MS: 50 patients with TN, 30 patients with trigeminal sensory disturbances other than TN (ongoing pain, dysaesthesia,...

journal_title：Pain

authors： Cruccu G,Biasiotta A,Di Rezze S,Fiorelli M,Galeotti F,Innocenti P,Mameli S,Millefiorini E,Truini A

更新日期：2009-06-01 00:00:00

abstract：:Primary burning mouth syndrome (BMS) is defined as an "intraoral burning or dysaesthetic sensation, recurring daily… more than 3 months, without clinically evident causative lesions" (IHS 2013). In addition to pain, taste alterations are frequent (dysgeusia, xerostomia). Although lacking clinical signs of neuropathy, ...

journal_title：Pain

authors： Jääskeläinen SK

更新日期：2018-03-01 00:00:00

abstract：:Many chronic pain syndromes, including fibromyalgia (FM), show evidence of central nervous system hyperexcitability related to central sensitization. Windup (WU) of second pain reflects increased excitability of spinal cord neurons that is related to central sensitization. Psychophysical testing can help characterize ...

journal_title：Pain

authors： Staud R,Price DD,Robinson ME,Mauderli AP,Vierck CJ

更新日期：2004-08-01 00:00:00

abstract：:We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered from a right-sided postcentral stroke. In this patient, we were able to demonstrate (i) a dissociation of discriminative and affective components of pain perception and, for the first time in humans, (ii) t...

journal_title：Pain

authors： Ploner M,Freund HJ,Schnitzler A

更新日期：1999-05-01 00:00:00

abstract：:Pain is a frequently observed non-motor symptom of patients with Parkinson's disease. In some patients, Parkinson's-related pain responds to dopaminergic treatment. In the present study, we aimed to elucidate whether subthalamic deep brain stimulation has a similar beneficial effect on pain in Parkinson's disease, and...

journal_title：Pain

authors： Sürücü O,Baumann-Vogel H,Uhl M,Imbach LL,Baumann CR

更新日期：2013-08-01 00:00:00

abstract：:Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...

journal_title：Pain

authors： Rabert DK,Koch BD,Ilnicka M,Obernolte RA,Naylor SL,Herman RC,Eglen RM,Hunter JC,Sangameswaran L

更新日期：1998-11-01 00:00:00

abstract：:Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and P...

journal_title：Pain

authors： Stroud MW,Thorn BE,Jensen MP,Boothby JL

更新日期：2000-02-01 00:00:00

abstract：:Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic...

journal_title：Pain

authors： Wang X,Wang S,Wang W,Duan J,Zhang M,Lv X,Niu C,Tan C,Wu Y,Yang J,Hu S,Xing J

更新日期：2016-10-01 00:00:00

abstract：:Unlike most classical analgesics, botulinum toxin type A (BoNT/A) does not alter acute nociceptive thresholds, and shows selectivity primarily for allodynic and hyperalgesic responses in certain pain conditions. We hypothesized that this phenomenon might be explained by characterizing the sensory neurons targeted by B...

journal_title：Pain

authors： Matak I,Rossetto O,Lacković Z

更新日期：2014-08-01 00:00:00

abstract：:Noxious C-fibre stimulation produces increased sensitivity within the injured area (primary hyperalgesia), and a surrounding zone of secondary hyperalgesia. As significant changes in nociceptive processing occur during development, we compared C-fibre induced primary and secondary hyperalgesia in rat pups aged 3, 10 a...

journal_title：Pain

authors： Walker SM,Meredith-Middleton J,Lickiss T,Moss A,Fitzgerald M

更新日期：2007-03-01 00:00:00

abstract：:Somatovisceral convergence was demonstrated in recordings from 15 of 16 spinothalamic tract cells in the lower thoracic spinal cords of anesthetized monkeys. Inputs were produced by mechanical (or sometimes electrical) stimulation of the skin over the lower trunk and by electrical stimulation of the greater splanchnic...

journal_title：Pain

authors： Foreman RD,Hancock MB,Willis WD

更新日期：1981-10-01 00:00:00

abstract：:Dysmenorrhea is the most prevalent gynecological disorder in women of child-bearing age. Dysmenorrhea is associated with central sensitization and functional and structural changes in the brain. Our recent brain morphometry study disclosed that dysmenorrhea is associated with trait-related abnormal gray matter (GM) ch...

journal_title：Pain

authors： Tu CH,Niddam DM,Yeh TC,Lirng JF,Cheng CM,Chou CC,Chao HT,Hsieh JC

更新日期：2013-09-01 00:00:00

abstract：:Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...

journal_title：Pain

authors： Forte BL,Slosky LM,Zhang H,Arnold MR,Staatz WD,Hay M,Largent-Milnes TM,Vanderah TW

更新日期：2016-12-01 00:00:00

abstract：:Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...

journal_title：Pain

authors： Davis KD,Dostrovsky JO

更新日期：1986-06-01 00:00:00

abstract：:We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain. The hypothalamic-pituitary-adrenal (HPA) axis is known to respond to stressful stimuli, including pain. To examine whether the blockade of tolerance by pain is related to HPA activity, ...

journal_title：Pain

authors： Vaccarino AL,Couret LC Jr

更新日期：1995-12-01 00:00:00

abstract：:A double-blind placebo-controlled crossover trial was used to determine the effects of topical ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on the sensory disturbances in 20 patients with complex regional pain syndrome (CRPS). On two occasions separated by at least one week, sensory tests to light tou...

journal_title：Pain

authors： Finch PM,Knudsen L,Drummond PD

更新日期：2009-11-01 00:00:00

abstract：:To better understand the association between pain recalled over a previous week and the average of multiple momentary reports of pain taken during the same period, 68 patients with chronic pain completed both weekly recall and momentary reports over a 2-week period and assessed their change in pain over the 2 weeks. P...

journal_title：Pain

authors： Stone AA,Broderick JE,Shiffman SS,Schwartz JE

更新日期：2004-01-01 00:00:00

abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...

journal_title：Pain

authors： Katz J,France C,Melzack R

更新日期：1989-03-01 00:00:00

abstract：:Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...

journal_title：Pain

authors： Kleggetveit IP,Namer B,Schmidt R,Helås T,Rückel M,Ørstavik K,Schmelz M,Jørum E

更新日期：2012-10-01 00:00:00

abstract：:Although the administration of opioids is the most effective treatment for pain, their efficacy is limited by the development of tolerance. The midbrain periaqueductal gray matter (PAG) participates in opioid analgesia and tolerance. Microinjection of morphine into PAG produces antinociception, probably through neuron...

journal_title：Pain

authors： Tortorici V,Morgan MM,Vanegas H

更新日期：2001-01-01 00:00:00

abstract：:A preliminary report of clinical study revealed that chronic discogenic low back pain could be treated by intradiscal methylene blue (MB) injection. We investigated the effect of intradiscal MB injection for the treatment of chronic discogenic low back pain in a randomized placebo-controlled trial. We recruited 136 pa...

journal_title：Pain

authors： Peng B,Pang X,Wu Y,Zhao C,Song X

更新日期：2010-04-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00