Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation.

abstract：:Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...

journal_title：Pain

authors： Sawynok J,Esser MJ,Reid AR

更新日期：1999-08-01 00:00:00

abstract：:In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spont...

journal_title：Pain

authors： Lin JC,Tsao WL,Lee HK,Wang Y

更新日期：1993-04-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00

abstract：:Ninety-two knees in 46 patients were evaluated with regard to pain: in 51 of these knees, implantation of a hinged endoprosthesis had been performed. The reliability and validity of 2 pain evaluation methods were assessed: the knee-pain questionnaire method (standard version including 10 questions and modified version...

journal_title：Pain

authors： Boeckstyns MEH,Backer M

更新日期：1989-07-01 00:00:00

abstract：:Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...

journal_title：Pain

authors： Ross FB,Smith MT

更新日期：1997-11-01 00:00:00

abstract：:Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...

journal_title：Pain

authors： Tesarz J,Gerhardt A,Leisner S,Janke S,Treede RD,Eich W

更新日期：2015-04-01 00:00:00

abstract：:The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...

journal_title：Pain

authors： Abbott FV,Guy ER

更新日期：1995-09-01 00:00:00

abstract：:The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...

journal_title：Pain

authors： Lipman JJ,Blumenkopf B,Parris WCV

更新日期：1987-07-01 00:00:00

abstract：:This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomf...

journal_title：Pain

authors： Langer SL,Romano J,Brown JD,Nielson H,Ou B,Rauch C,Zullo L,Levy RL

更新日期：2017-09-01 00:00:00

abstract：:An abundance of animal research suggests that fear inhibits pain whereas anxiety increases it. Human studies on this topic are more scarce, and the existing evidence seems rather inconsistent. Therefore, we aimed to investigate the divergent effects of both negative emotional states-that is, pain-related fear and anxi...

journal_title：Pain

authors： Meulders A,Vansteenwegen D,Vlaeyen JWS

更新日期：2012-05-01 00:00:00

abstract：:Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia. Although evoked responses in neuropathic pain models are well characterized, determining the presence of spontaneous pain is more challenging. We determined whether the chronic constriction injury (CCI) mo...

journal_title：Pain

authors： Dalm BD,Reddy CG,Howard MA,Kang S,Brennan TJ

更新日期：2015-12-01 00:00:00

abstract：:Data from daily diaries were used to analyze pain coping processes in rheumatoid arthritis patients. For 30 consecutive days, 53 individuals described the pain coping strategies they used that day and rated the efficacy of their coping, joint pain, and positive and negative mood. Relations among variables were examine...

journal_title：Pain

authors： Keefe FJ,Affleck G,Lefebvre JC,Starr K,Caldwell DS,Tennen H

更新日期：1997-01-01 00:00:00

abstract：:In this study, we examined the relationship between astrocyte activation in the cuneate nucleus (CN) and behavioral hypersensitivity after chronic constriction injury (CCI) of the median nerve. In addition, we also examined the effects of pre-emptive treatment with a number of drugs on astrocyte activation and hyperse...

journal_title：Pain

authors： Chen JJ,Lue JH,Lin LH,Huang CT,Chiang RP,Chen CL,Tsai YJ

更新日期：2010-01-01 00:00:00

abstract：:A growing body of literature suggests that the experience of clinical pain differs across ethnocultural groups. Additionally, some evidence indicates greater sensitivity to experimentally induced pain among African Americans; however, most studies have included only one pain modality. This study examined ethnic differ...

journal_title：Pain

authors： Campbell CM,Edwards RR,Fillingim RB

更新日期：2005-01-01 00:00:00

abstract：:We assessed for the first time the long-term maintenance of repetitive transcranial magnetic stimulation (rTMS)-induced analgesia in patients with chronic widespread pain due to fibromyalgia. Forty consecutive patients were randomly assigned, in a double-blind fashion, to 2 groups: one receiving active rTMS (n=20) and...

journal_title：Pain

authors： Mhalla A,Baudic S,de Andrade DC,Gautron M,Perrot S,Teixeira MJ,Attal N,Bouhassira D

更新日期：2011-07-01 00:00:00

abstract：:This was a multicenter, double-blind (DB), placebo-controlled, randomized discontinuation trial to evaluate the efficacy of pregabalin monotherapy for durability of effect on fibromyalgia (FM) pain. The trial included a 6-week open-label (OL) pregabalin-treatment period followed by 26-week DB treatment with placebo or...

journal_title：Pain

authors： Crofford LJ,Mease PJ,Simpson SL,Young JP Jr,Martin SA,Haig GM,Sharma U

更新日期：2008-06-01 00:00:00

abstract：:In a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 day...

journal_title：Pain

authors： Procacci P,Francini F,Zoppi M,Maresca M

更新日期：1975-06-01 00:00:00

abstract：:Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...

journal_title：Pain

authors： Gordon NC,Heller PH,Levine JD

更新日期：1992-02-01 00:00:00

abstract：:Substance P like immunoreactivity (SPLI) and total protein (TP) concentrations in plasma and saliva were measured in 80 healthy female patients divided into the following four groups: women in group 1 were not pregnant and they were awaiting tubal ligation; women in group 2 were not pregnant but they experienced acute...

journal_title：Pain

authors： Dalby PL,Ramanathan S,Rudy TE,Roy L,Amenta JS,Aber A

更新日期：1997-02-01 00:00:00

abstract：:Osteoarthritis (OA) is a debilitating disease in which primarily weight-bearing joints undergo progressive degeneration. Despite the widespread prevalence of OA in the adult population, very little is known about the factors responsible for the generation and maintenance of OA pain. Vasoactive intestinal peptide (VIP)...

journal_title：Pain

authors： McDougall JJ,Watkins L,Li Z

更新日期：2006-07-01 00:00:00

abstract：:Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort d...

journal_title：Pain

authors： Krebs EE,Becker WC,Zerzan J,Bair MJ,McCoy K,Hui S

更新日期：2011-08-01 00:00:00

abstract：:The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...

journal_title：Pain

authors： Gutierrez-Mecinas M,Bell AM,Marin A,Taylor R,Boyle KA,Furuta T,Watanabe M,Polgár E,Todd AJ

更新日期：2017-03-01 00:00:00

abstract：:Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...

journal_title：Pain

authors： Kornguth PJ,Keefe FJ,Conaway MR

更新日期：1996-08-01 00:00:00

abstract：:A large sample of staff physicians and residents (n = 193) responded to a questionnaire in which they were asked to rate 10 pain descriptors for level of applicability to 4 common acute and chronic pain syndromes. The purpose of the study was to examine the extent to which physicians would agree on the ratings, and wh...

journal_title：Pain

authors： Tearnan BH,Dar R

更新日期：1986-07-01 00:00:00

abstract：:Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for ...

journal_title：Pain

authors： Gündel H,Valet M,Sorg C,Huber D,Zimmer C,Sprenger T,Tölle TR

更新日期：2008-07-15 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:While a variety of cultural, psychological and physiological factors contribute to variability in both clinical and experimental contexts, the role of genetic factors in human pain sensitivity is increasingly recognized as an important element. This study was performed to evaluate genetic influences on variability in ...

journal_title：Pain

authors： Kim H,Neubert JK,San Miguel A,Xu K,Krishnaraju RK,Iadarola MJ,Goldman D,Dionne RA

更新日期：2004-06-01 00:00:00

abstract：:The failure to translate research evidence into day-to-day clinical practices is identified as a significant reason for suboptimal quality care across the health system, including procedural pain management in children. Clinical practice guidelines (CPGs) have been developed to assist in this process by synthesizing a...

journal_title：Pain

authors： Taddio A,Rogers JM

更新日期：2015-04-01 00:00:00

abstract：:A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...

journal_title：Pain

authors： Morgan MM,Fields HL

更新日期：1993-01-01 00:00:00

abstract：:This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...

journal_title：Pain

authors： Mailis A,Plapler P,Ashby P,Shoichet R,Roe S

更新日期：1997-03-01 00:00:00