当前位置： SCI文献检索 > PAIN期刊下所有文献 > Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.

Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.

Abstract：

:Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort drawn from Department of Veterans Affairs (VA) health care databases, January 1, 2000, to December 31, 2007. We included 28,554 patients who received methadone and 79,938 who received long-acting morphine from VA pharmacies. Compared with those who received long-acting morphine, patients who received methadone were younger, less likely to have some medical comorbidities, and more likely to have psychiatric and substance use disorders. Patients were stratified into quintiles according to propensity score; the probability of receiving methadone was conditional on demographic, clinical, and VA service area variables. Overall propensity-adjusted mortality was lower for methadone than for morphine. Hazard ratios varied across propensity score quintiles; the magnitude of the between-drug difference in mortality decreased as the propensity to receive methadone increased. Mortality was significantly lower for methadone in all but the last quintile, in which there was no between-drug difference in mortality (hazard ratio=0.92, 95% confidence interval=0.74, 1.16). Multiple sensitivity analyses found either no difference in mortality between methadone and long-acting morphine or lower mortality rates among patients who received methadone. In summary, we found no evidence of excess all-cause mortality among VA patients who received methadone compared with those who received long-acting morphine. Randomized trials and prospective observational research are needed to better understand the relative safety of long-acting opioids.

journal_name

Pain

journal_title

Pain

authors

Krebs EE,Becker WC,Zerzan J,Bair MJ,McCoy K,Hui S

doi

10.1016/j.pain.2011.03.023

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1789-1795

issue

eissn

0304-3959

issn

1872-6623

pii

00006396-201108000-00018

journal_volume

152

pub_type

杂志文章

在线工具

Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.