Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesion.

abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...

journal_title：Pain

authors： Lang E,Hord HA,Denson D

更新日期：1996-11-01 00:00:00

abstract：:Occupational activities such as lifting loads, working in constrained spaces, and training increase the risk of pain-related musculoskeletal disorders (MSDs) in military veterans. Few studies have investigated MSD and psychological disorder in veterans, and previous studies had limitations. This cross-sectional study ...

journal_title：Pain

authors： Kelsall HL,McKenzie DP,Forbes AB,Roberts MH,Urquhart DM,Sim MR

更新日期：2014-04-01 00:00:00

abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...

journal_title：Pain

authors： Inbal R,Rousso M,Ashur H,Wall PD,Devor M

更新日期：1987-02-01 00:00:00

abstract：:Investigating dose-dependent effects of placebo analgesia (PA) in laboratory subjects undergoing pain testing, we evaluated 2 hypotheses: (1) greater expectancy for relief produces greater PA, and (2) cued expectancy for relief triggered by a predictive cue leads to more enhanced analgesia than does passive expectancy...

journal_title：Pain

authors： Nakamura Y,Donaldson GW,Kuhn R,Bradshaw DH,Jacobson RC,Chapman RC

更新日期：2012-01-01 00:00:00

abstract：:The aims of this study were threefold. Firstly, to investigate the effect of increasing threat-expectancy on attentional biases towards pain-related words. Secondly, to determine the interaction between threat-expectancy and the effectiveness of two coping strategies on pain threshold and tolerance. Thirdly, to invest...

journal_title：Pain

authors： Boston A,Sharpe L

更新日期：2005-12-15 00:00:00

abstract：:The termination of an unpleasant or painful somatic condition can produce a rewarding sense of relief, even if the stimulus that causes the termination is itself unpleasant or painful under normal circumstances. We aimed to identify central neural mechanisms of pain relief from capsaicin-elicited heat-hyperalgesia by ...

journal_title：Pain

authors： Mohr C,Leyendecker S,Mangels I,Machner B,Sander T,Helmchen C

更新日期：2008-10-15 00:00:00

abstract：:The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain. Most of the patients had evidence of musculoskeletal pain while some had a history suggesting pain of neurogenic origin. Two patients had mixed elements of neurogenic and musculoskeletal pain. Amitriptyline was more effective tha...

journal_title：Pain

authors： Sharav Y,Singer E,Schmidt E,Dionne RA,Dubner R

更新日期：1987-11-01 00:00:00

abstract：:Managing acute procedural pain effectively in preterm infants in the neonatal intensive care unit remains a significant problem. The objectives of this study were to evaluate the efficacy of breastfeeding for reducing pain and to determine if breastfeeding skills were altered after this treatment. Fifty-seven infants ...

journal_title：Pain

authors： Holsti L,Oberlander TF,Brant R

更新日期：2011-11-01 00:00:00

abstract：:Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...

journal_title：Pain

authors： Andreou AP,Holland PR,Lasalandra MP,Goadsby PJ

更新日期：2015-03-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...

journal_title：Pain

authors： Egan KJ,Ready LB,Nessly M,Greer BE

更新日期：1992-04-01 00:00:00

abstract：:Pediatric chronic pain is associated with numerous negative outcomes including increased physical disability, increased rates of depression and anxiety, and decreased quality of life (QOL). Pain catastrophizing-broadly conceptualized as including rumination, magnification, and helplessness cognitions surrounding one's...

journal_title：Pain

authors： Miller MM,Meints SM,Hirsh AT

更新日期：2018-12-01 00:00:00

abstract：:Growth mixture modeling (GMM) identified latent groups based on treatment outcome trajectories of headache disability measures in patients in headache subspecialty treatment clinics. Using a longitudinal design, 219 patients in headache subspecialty clinics in 4 large cities throughout Ohio provided data on their head...

journal_title：Pain

authors： Lewis KN,Heckman BD,Himawan L

更新日期：2011-08-01 00:00:00

abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...

journal_title：Pain

authors： Keefe FJ,Shelby RA,Somers TJ,Varia I,Blazing M,Waters SJ,McKee D,Silva S,She L,Blumenthal JA,O'Connor J,Knowles V,Johnson P,Bradley L

更新日期：2011-04-01 00:00:00

abstract：:The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...

journal_title：Pain

authors： Stevens BJ,Johnston CC,Horton L

更新日期：1994-10-01 00:00:00

abstract：:Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...

journal_title：Pain

authors： Baseer N,Al-Baloushi AS,Watanabe M,Shehab SA,Todd AJ

更新日期：2014-11-01 00:00:00

abstract：:Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...

journal_title：Pain

authors： Ward SE,Hernandez L

更新日期：1994-08-01 00:00:00

abstract：:Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...

journal_title：Pain

authors： Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

更新日期：2020-09-30 00:00:00

abstract：:Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...

journal_title：Pain

authors： Elliott K,Hynansky A,Inturrisi CE

更新日期：1994-12-01 00:00:00

abstract：:Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...

journal_title：Pain

authors： Li MJ,Liu LY,Chen L,Cai J,Wan Y,Xing GG

更新日期：2017-04-01 00:00:00

abstract：:Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...

journal_title：Pain

authors： Li CY,Zhang XL,Matthews EA,Li KW,Kurwa A,Boroujerdi A,Gross J,Gold MS,Dickenson AH,Feng G,Luo ZD

更新日期：2006-11-01 00:00:00

abstract：:Ten patients with organic nerve injury causing chronic neuropathic pain were tested for the effects of intravenous lidocaine versus saline upon psychophysical somatosensory variables. The variables assessed were the subjective magnitude of pain, area of mechanical hyperalgesia and presence and magnitude of thermal hea...

journal_title：Pain

authors： Marchettini P,Lacerenza M,Marangoni C,Pellegata G,Sotgiu ML,Smirne S

更新日期：1992-03-01 00:00:00

abstract：:The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...

journal_title：Pain

authors： Wilson JF,Brockopp GW,Kryst S,Steger H,Witt WO

更新日期：1992-09-01 00:00:00

abstract：:Gabapentin is an effective option for the treatment of neuropathic pain syndromes because of its efficacy and favorable side-effect profile. A case is presented of a 58 year old man who developed a painful polyneuropathy while being treated with gabapentin. ...

journal_title：Pain

authors： Gould HJ

更新日期：1998-02-01 00:00:00

abstract：:In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (WAS) rat model. However, it is unknown whether enhanced visceral pain and permeability are intrinsically linked...

journal_title：Pain

authors： Creekmore AL,Hong S,Zhu S,Xue J,Wiley JW

更新日期：2018-09-01 00:00:00

abstract：:Altered pain sensitivity is believed to play an important role for chronification of headache. It has however mainly been evaluated in highly selected patients from headache clinics and never in longitudinal studies. The present study is a 12-year follow-up of a population-based study of primary headache disorders and...

journal_title：Pain

authors： Buchgreitz L,Lyngberg AC,Bendtsen L,Jensen R

更新日期：2008-07-31 00:00:00

abstract：:Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than dimin...

journal_title：Pain

authors： King T,Vardanyan A,Majuta L,Melemedjian O,Nagle R,Cress AE,Vanderah TW,Lai J,Porreca F

更新日期：2007-11-01 00:00:00

abstract：:Treatment of neuropathic pain is a major clinical challenge that has been met with minimal success. After peripheral nerve injury, a decrease in the expression of the K-Cl cotransporter KCC2, a major neuronal Cl(-) extruder, leads to pathologic alterations in GABA(A) and glycine receptor function in the spinal cord. T...

journal_title：Pain

authors： Asiedu M,Ossipov MH,Kaila K,Price TJ

更新日期：2010-02-01 00:00:00

abstract：:Potential applications of attention bias modification (ABM) for acute and chronic pain patients are investigated. In study 1, 54 acute back pain patients (46 of whom completed the study) were recruited at their initial physiotherapy session and randomised to receive 1 session of ABM or placebo. Patients were followed ...

journal_title：Pain

authors： Sharpe L,Ianiello M,Dear BF,Perry KN,Refshauge K,Nicholas MK

更新日期：2012-03-01 00:00:00

abstract：:Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...

journal_title：Pain

authors： Reyes-Gibby CC,Shete S,Rakvåg T,Bhat SV,Skorpen F,Bruera E,Kaasa S,Klepstad P

更新日期：2007-07-01 00:00:00