Abstract:
:Gabapentin is an effective option for the treatment of neuropathic pain syndromes because of its efficacy and favorable side-effect profile. A case is presented of a 58 year old man who developed a painful polyneuropathy while being treated with gabapentin.
journal_name
Painjournal_title
Painauthors
Gould HJdoi
10.1016/s0304-3959(97)00188-7subject
Has Abstractpub_date
1998-02-01 00:00:00pages
341-3issue
2-3eissn
0304-3959issn
1872-6623journal_volume
74pub_type
杂志文章相关文献
PAIN文献大全abstract::Lamina I of the spinal cord plays a key role in sensory transmission between afferent activity and the CNS. Studies have shown lamina I neurones to have distinct response properties compared to deep dorsal horn neurones, but little is known regarding excitatory amino acid mechanisms in their responses. Spinal electrop...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.12.004
更新日期:2004-03-01 00:00:00
abstract::Clinicians use patients' recall of pain and disability relief as indicators of therapeutic effectiveness. Recall can change over time, however, and is influenced by factors other than true relief, including current health status. We have determined the trend in the relative contribution of current pain/disability and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00377-3
更新日期:2002-01-01 00:00:00
abstract::The purpose of this study is to analyze cancer breakthrough pain (BP) characteristics and how BP responds to conventional cancer pain management. Seventy-four cancer pain patients with worst pain severity >or=4 out of 10 completed the Brief Pain Inventory (BPI), Memorial Symptom Assessment Scale-Short Form, Functional...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(02)00293-2
更新日期:2003-01-01 00:00:00
abstract::A systematic review and meta-analysis of population-based epidemiological studies was undertaken to determine the prevalence of foot and ankle pain in middle and old age. Searches were conducted in the following electronic databases from inception to October 2010: PubMed, EMBASE, AMED, CINAHL, Cochrane, PEDro, and Spo...
journal_title:Pain
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.pain.2011.09.019
更新日期:2011-12-01 00:00:00
abstract::Ectopically generated and antidromically conducted nerve impulses were recorded in 5 patients with tungsten microelectrodes inserted into skin nerve fascicles. All patients had mainly positive sensory symptoms and reported paresthesiae which could be provoked by different maneuvers which suggested increased mechanosen...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90013-7
更新日期:1984-11-01 00:00:00
abstract::In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90077-3
更新日期:1993-05-01 00:00:00
abstract::Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.06.010
更新日期:2012-11-01 00:00:00
abstract::Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervent...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.07.006
更新日期:2010-10-01 00:00:00
abstract::Colonoscopy is an invaluable tool for the screening and diagnosis of many colonic diseases. For most colonoscopies, moderate sedation is used during the procedure. However, insufflation of the colon produces a nociceptive stimulus that is usually accompanied by facial grimacing/groaning while under sedation. The objec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000446
更新日期:2016-04-01 00:00:00
abstract::To better understand the association between pain recalled over a previous week and the average of multiple momentary reports of pain taken during the same period, 68 patients with chronic pain completed both weekly recall and momentary reports over a 2-week period and assessed their change in pain over the 2 weeks. P...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.09.020
更新日期:2004-01-01 00:00:00
abstract::We investigated whether intraoperative 'subanesthetic doses' of ketamine have a postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of administration, either systemic (intravenous, i.v.) or epidural. One hundred patients scheduled for rectal adenocarcinoma surgery under combined...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(01)00278-0
更新日期:2001-06-01 00:00:00
abstract::Spasticity is a major clinical manifestation of spinal cord injury and upper motor neuron syndrome. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00255-9
更新日期:2000-03-01 00:00:00
abstract::Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.02.006
更新日期:2005-05-01 00:00:00
abstract::Using the chronic constriction injury (CCI) model of neuropathic pain, we profiled gene expression in the rat spinal cord, and identified SIP30 as a gene whose expression was elevated after CCI. SIP30 was previously shown to interact with SNAP25, but whose function was otherwise unknown. We now show that in the spinal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.07.011
更新日期:2009-11-01 00:00:00
abstract::On a no treatment trial, a group of 24 oriental subjects rated cold pressor pain as significantly more painful and distressing than did a group of 24 occidental subjects. For half of the Orientals and half of the Occidentals, a second trial was conducted after acupuncture analgesia had been induced. The remaining 12 O...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90086-0
更新日期:1977-10-01 00:00:00
abstract::The neuropeptide bradykinin (BK) sensitizes nociceptor activation following its release in response to inflammatory injury. Thereafter, the bioactivity of bradykinin is controlled by the enzymatic activities of circulating peptidases. One such enzyme, the metalloendopeptidase EC3.4.24.15 (EP24.15), is co-expressed wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.02.044
更新日期:2011-07-01 00:00:00
abstract::Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.02.006
更新日期:2007-11-01 00:00:00
abstract::The aims of this study were threefold. Firstly, to investigate the effect of increasing threat-expectancy on attentional biases towards pain-related words. Secondly, to determine the interaction between threat-expectancy and the effectiveness of two coping strategies on pain threshold and tolerance. Thirdly, to invest...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2005.09.032
更新日期:2005-12-15 00:00:00
abstract::Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90180-J
更新日期:1992-04-01 00:00:00
abstract::Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recoveri...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00212-4
更新日期:2003-09-01 00:00:00
abstract::Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.10.023
更新日期:2007-07-01 00:00:00
abstract::Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00014-J
更新日期:1995-10-01 00:00:00
abstract::The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90083-2
更新日期:1987-07-01 00:00:00
abstract::Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.05.018
更新日期:2014-08-01 00:00:00
abstract::The aim of this study was to test the capacity of the Fear Avoidance Model to explain the relationship between pain and disability in patients with whiplash-associated disorders. Using the method of Baron and Kenny, we assessed the mediating effect of fear of movement on the cross-sectional and longitudinal relationsh...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.09.023
更新日期:2012-01-01 00:00:00
abstract::Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ("autotomy"). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited tr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00295-0
更新日期:2001-08-01 00:00:00
abstract::Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000240
更新日期:2015-09-01 00:00:00
abstract::Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(97)03362-9
更新日期:1997-06-01 00:00:00
abstract::Surgery and trauma are recognised as important causes of chronic pain, although their overall contribution has not been systematically studied. This paper reports on the contribution of surgery and trauma to chronic pain among 5130 patients attending 10 outpatient clinics located throughout North Britain. Surgery cont...
journal_title:Pain
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in the neuroma model of neuropathic pain (HA rats (high autotomy) and LA ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.07.020
更新日期:2009-11-01 00:00:00