Sex differences in functional brain activation during noxious visceral stimulation in rats.

abstract：:The social determinants of health (SDH) are known to differentially impact outcomes from many noncommunicable diseases; however, their potential role in low back pain (LBP) is poorly defined. This review endeavours to comprehensively inform the field of their relevance. Our research question was: "How do the broad ran...

journal_title：Pain

authors： Karran EL,Grant AR,Moseley GL

更新日期：2020-11-01 00:00:00

abstract：:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...

journal_title：Pain

authors： Sawynok J,Reid AR,Doak GJ

更新日期：1995-05-01 00:00:00

abstract：:Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...

journal_title：Pain

authors： Eliav E,Teich S,Nitzan D,El Raziq DA,Nahlieli O,Tal M,Gracely RH,Benoliel R

更新日期：2003-08-01 00:00:00

abstract：:The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...

journal_title：Pain

authors： Nielsen TA,Eriksen MA,Gazerani P,Andersen HH

更新日期：2018-10-01 00:00:00

abstract：:This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise. Low caffeine consuming college-aged males (N=12) ingested one of two doses of caffeine (5 or 10 mg.kg(-1) body weight) o...

journal_title：Pain

authors： O'Connor PJ,Motl RW,Broglio SP,Ely MR

更新日期：2004-06-01 00:00:00

abstract：:An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...

journal_title：Pain

authors： Procacci P,Maresca M

更新日期：1991-06-01 00:00:00

abstract：:Animal studies have suggested that the cerebellum, in addition to its motor functions, also has a role in pain processing and modulation, possibly because of its extensive connections with the prefrontal cortex and with brainstem regions involved in descending pain control. Consistently, human imaging studies have sho...

journal_title：Pain

authors： Ruscheweyh R,Kühnel M,Filippopulos F,Blum B,Eggert T,Straube A

更新日期：2014-07-01 00:00:00

abstract：:Advances in pain measurement using ecological momentary assessments offer novel opportunities for understanding the temporal dynamics of pain. This study examined whether regime-switching models, which capture processes characterized by recurrent shifts between different states, provide clinically relevant information...

journal_title：Pain

authors： Schneider S,Junghaenel DU,Ono M,Stone AA

更新日期：2018-07-01 00:00:00

abstract：:Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...

journal_title：Pain

authors： Zhuang ZY,Gerner P,Woolf CJ,Ji RR

更新日期：2005-03-01 00:00:00

abstract：:Experimental muscle pain was elicited by bolus injection of 0.15 ml of 5% hypertonic saline into the human masseter muscle. The sensory experience was described using 10-cm visual analogue scales (VAS) and the McGill Pain Questionnaires (MPQ) on 10 subjects. Effects of pain on deliberately unilateral mastication were ...

journal_title：Pain

authors： Svensson P,Arendt-Nielsen L,Houe L

更新日期：1996-02-01 00:00:00

abstract：:This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold)...

journal_title：Pain

authors： da Costa DSM,Meotti FC,Andrade EL,Leal PC,Motta EM,Calixto JB

更新日期：2010-03-01 00:00:00

abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...

journal_title：Pain

authors： Hardy PAJ,Wells JCD

更新日期：1989-02-01 00:00:00

abstract：:Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

journal_title：Pain

authors： Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

更新日期：2011-12-01 00:00:00

abstract：:Gabapentin is an effective option for the treatment of neuropathic pain syndromes because of its efficacy and favorable side-effect profile. A case is presented of a 58 year old man who developed a painful polyneuropathy while being treated with gabapentin. ...

journal_title：Pain

authors： Gould HJ

更新日期：1998-02-01 00:00:00

abstract：:Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...

journal_title：Pain

authors： Baseer N,Al-Baloushi AS,Watanabe M,Shehab SA,Todd AJ

更新日期：2014-11-01 00:00:00

abstract：:Recent studies have suggested that spouses of chronic pain patients are at risk for emotional and marital maladjustment. This study explored the role of patient and spouse gender in mediating the effects of chronic pain on the spouse's adjustment. Eight-three chronic low back pain patients and their spouses completed ...

journal_title：Pain

authors： Romano JM,Turner JA,Clancy SL

更新日期：1989-12-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00

abstract：:Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may unde...

journal_title：Pain

authors： Schmahl C,Greffrath W,Baumgärtner U,Schlereth T,Magerl W,Philipsen A,Lieb K,Bohus M,Treede RD

更新日期：2004-07-01 00:00:00

abstract：:The perception of pain is determined by a combination of genetic, neurobiological, cultural, and emotional factors. Recent studies have demonstrated an association between specific genotypes and pain perception. Particular focus has been given to the triallelic polymorphism in the promoter region of the serotonin tran...

journal_title：Pain

authors： Horjales-Araujo E,Demontis D,Lund EK,Vase L,Finnerup NB,Børglum AD,Jensen TS,Svensson P

更新日期：2013-08-01 00:00:00

abstract：:A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by 2 isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1 (NO-GC1) and 2 (NO-GC2). However, the specific functions of the 2 iso...

journal_title：Pain

authors： Petersen J,Mergia E,Kennel L,Drees O,Steubing RD,Real CI,Kallenborn-Gerhardt W,Lu R,Friebe A,Koesling D,Schmidtko A

更新日期：2019-03-01 00:00:00

abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...

journal_title：Pain

authors： Inbal R,Rousso M,Ashur H,Wall PD,Devor M

更新日期：1987-02-01 00:00:00

abstract：:Coeliac plexus block (CPB) is one of the few neurolytic procedures that is still considered very useful in managing chronic cancer pain. We describe what we believe to be the fifth case in the literature of paraplegia following coeliac plexus block with ethyl alcohol. Clinical and neurophysiological examination confir...

journal_title：Pain

authors： De Conno F,Caraceni A,Aldrighetti L,Magnani G,Ferla G,Comi G,Ventafridda V

更新日期：1993-12-01 00:00:00

abstract：:Children of parents with chronic pain have higher rates of pain and internalizing (eg, anxiety and depressive) symptoms than children of parents without chronic pain. Parental modeling of pain behaviour and reinforcement of child pain have been hypothesized to underlie these relationships. These mechanisms were tested...

journal_title：Pain

authors： Higgins KS,Chambers CT,Rosen NO,Sherry S,Mohammadi S,Lynch M,Campbell-Yeo M,Clark AJ

更新日期：2019-11-01 00:00:00

abstract：:Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...

journal_title：Pain

authors： Ross FB,Smith MT

更新日期：1997-11-01 00:00:00

abstract：:Is a person's response to one noxious stimulus similar to his/her responses to other noxious stimuli? This long-investigated topic in pain research has provided inconclusive results. In the present study, 2 samples were studied: one using 60 healthy volunteers and the other using 29 patients with coronary artery disea...

journal_title：Pain

authors： Janal MN,Glusman M,Kuhl JP,Clark WC

更新日期：1994-09-01 00:00:00

abstract：:The ability to sense and respond to thermal stimuli at varied environmental temperatures is essential for survival in seasonal areas. In this study, we show that mice respond similarly to ramping changes in temperature from a wide range of baseline temperatures. Further investigation suggests that this ability to adap...

journal_title：Pain

authors： Brenner DS,Golden JP,Vogt SK,Dhaka A,Story GM,Gereau RW IV

更新日期：2014-10-01 00:00:00

abstract：:Dysmenorrhea is the most prevalent gynecological disorder in women of child-bearing age. Dysmenorrhea is associated with central sensitization and functional and structural changes in the brain. Our recent brain morphometry study disclosed that dysmenorrhea is associated with trait-related abnormal gray matter (GM) ch...

journal_title：Pain

authors： Tu CH,Niddam DM,Yeh TC,Lirng JF,Cheng CM,Chou CC,Chao HT,Hsieh JC

更新日期：2013-09-01 00:00:00

abstract：:Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...

journal_title：Pain

authors： Vachon-Presseau E,Roy M,Woo CW,Kunz M,Martel MO,Sullivan MJ,Jackson PL,Wager TD,Rainville P

更新日期：2016-08-01 00:00:00

abstract：:Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...

journal_title：Pain

authors： Stokvis A,van der Avoort DJC,van Neck JW,Hovius SER,Coert HJ

更新日期：2010-12-01 00:00:00

abstract：:The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...

journal_title：Pain

authors： Kan HW,Chang CH,Lin CL,Lee YC,Hsieh ST,Hsieh YL

更新日期：2018-08-01 00:00:00