Abstract：
:The ability to sense and respond to thermal stimuli at varied environmental temperatures is essential for survival in seasonal areas. In this study, we show that mice respond similarly to ramping changes in temperature from a wide range of baseline temperatures. Further investigation suggests that this ability to adapt to different ambient environments is based on rapid adjustments made to a dynamic temperature set point. The adjustment of this set point requires transient receptor potential cation channel, subfamily member 8 (TRPM8), but not transient receptor potential cation channel, subfamily A, member 1 (TRPA1), and is regulated by phospholipase C (PLC) activity. Overall, our findings suggest that temperature response thresholds in mice are dynamic, and that this ability to adapt to environmental temperature seems to mirror the in vitro findings that PLC-mediated hydrolysis of phosphoinositol 4,5-bisphosphate modulates TRPM8 activity and thereby regulates the response thresholds to cold stimuli.
journal_name
Painjournal_title
Painauthors
Brenner DS,Golden JP,Vogt SK,Dhaka A,Story GM,Gereau RW IVdoi
10.1016/j.pain.2014.08.001subject
Has Abstractpub_date
2014-10-01 00:00:00pages
2124-33issue
10eissn
0304-3959issn
1872-6623pii
S0304-3959(14)00345-5journal_volume
155pub_type
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