Abstract:
:Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to the plantar or the dorsal surface of the paw. During testing the rat was either in a restraint tube with hindlimbs hanging semi-extended without weight bearing or it was standing on a metal grid (bearing its own weight). In intact rats, the withdrawal thresholds were significantly lower when the stimulus site was the dorsal hairy skin rather than the plantar glabrous skin. Also, thresholds were significantly lower when the hindlimbs were not bearing weight. Following carrageenan-induced unilateral inflammation of the plantar paw or a tibial nerve cut there was a marked threshold decrease to test stimuli applied to plantar or dorsal paw, respectively, ipsilateral to the pathological condition in standing rats. However, when the hindlimbs were not weight bearing the unilateral threshold decrease was markedly attenuated (carrageenan-treated rats) or completely abolished (tibial cut). In contrast, in rats with a unilateral spinal nerve ligation the threshold decrease ipsilateral to the nerve lesion was highly significant independent of the weight bearing of the hindlimbs. The results indicate that weight bearing of hindlimbs is an important confounding factor in the assessment of tactile allodynia in rats.
journal_name
Painjournal_title
Painauthors
Kauppila T,Kontinen VK,Pertovaara Adoi
10.1016/S0304-3959(97)00143-7subject
Has Abstractpub_date
1998-01-01 00:00:00pages
55-59issue
1eissn
0304-3959issn
1872-6623pii
00006396-199801010-00008journal_volume
74pub_type
杂志文章相关文献
PAIN文献大全abstract::Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00043-3
更新日期:1999-08-01 00:00:00
abstract::The current investigation studied the effectiveness of a secondary prevention program for nurses with back pain who were deemed at risk for developing a chronic problem. A 2 X 3 repeated measures design was employed with 2 groups and 3 assessment periods. The treatment group received an intervention designed to reduce...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(89)90024-9
更新日期:1989-02-01 00:00:00
abstract::Primary neuronal cell bodies, whose peripheral axons comprised the cutaneous branch of the mylohyoid nerve or innervated the mandibular molar tooth pulp or the cornea, were labeled with HRP and their cross-sectional area was analyzed. Most of their cell bodies were smaller than 1000 microns2 in cross-sectional area an...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90050-4
更新日期:1988-03-01 00:00:00
abstract::Fibromyalgia (FM) syndrome represents a great challenge for clinicians and researchers because the efficacy of currently available treatments is limited. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for reducing functional impairment as well as the role of mindfulness-related construct...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/j.pain.0000000000001655
更新日期:2019-11-01 00:00:00
abstract::Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90229-Q
更新日期:1991-12-01 00:00:00
abstract::Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than dimin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.06.026
更新日期:2007-11-01 00:00:00
abstract::Multimodal neuroimaging studies provide support for a role of alterations in sensory processing circuits and endogenous pain modulatory systems in provoked vestibulodynia (PVD). In this study, we tested the hypotheses that PVD compared with healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001532
更新日期:2019-07-01 00:00:00
abstract::Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90022-1
更新日期:1994-12-01 00:00:00
abstract::In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.01.006
更新日期:2012-04-01 00:00:00
abstract::The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001723
更新日期:2020-02-01 00:00:00
abstract::We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history, examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00244-4
更新日期:2000-02-01 00:00:00
abstract::Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.01.024
更新日期:2010-04-01 00:00:00
abstract::The enzyme 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR) catalyzes the synthesis and bioavailability of 3alpha,5alpha-neurosteroids as allopregnanolone (3alpha,5alpha-THP) which activates GABA(A) receptors and blocks T-type calcium channels involved in pain mechanisms. Here, we used a multidisciplinary approach ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(94)90053-1
更新日期:1994-10-01 00:00:00
abstract::Visceral pain/discomfort is the cardinal complaints and treatment targets for functional gastrointestinal disorders (FGID). However, effective treatment for such pain is limited and often associated with high placebo effects. The mechanisms of placebo effects in visceral pain are unclear. We used functional neuroimagi...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2009.10.012
更新日期:2010-01-01 00:00:00
abstract::Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.01.011
更新日期:2009-04-01 00:00:00
abstract::These experiments quantitatively analyzed effects of electrical midbrain stimulation on a nociceptive hind limb flexion reflex in rats anesthetized with sodium pentobarbital. We recorded the force of isometric hind limb flexion withdrawal, and related flexor electromyographic (EMG) activity, elicited by noxious heat (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90092-9
更新日期:1988-05-01 00:00:00
abstract::Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.10.003
更新日期:2008-07-15 00:00:00
abstract::Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)91039-6
更新日期:1987-05-01 00:00:00
abstract::Constipation is the most common adverse event (AE) of opioid therapy. This multicenter, phase 2 study evaluated the efficacy and safety of linaclotide in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain syndromes (NCT02270983). Adults with OIC (<3 spontaneous bowel movements [SBMs]/we...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001754
更新日期:2020-05-01 00:00:00
abstract::Our goal was to examine the association between mental health disorders (MHD) and subsequent risk of opioid use among commercially insured youth and adults (aged 14-64 years) with comorbid chronic noncancer pain (CNCP) conditions. We conducted a retrospective cohort study using IQVIA Health Plan Claims database from J...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001934
更新日期:2020-10-01 00:00:00
abstract::Iatrogenic Cushing's syndrome has been reported after the use of nasal, aerosol, oral, and intramuscular steroid preparations. Presented is a case of Cushing's syndrome due to an epidural injection of methylprednisolone. A 24-year-old man had left arm pain after an occupational injury. Electromyography revealed C7 rad...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91054-M
更新日期:1990-01-01 00:00:00
abstract::Patients suffering from postherpetic neuralgia often complain about hypo- or hypersensation in the affected dermatome. The loss of thermal sensitivity has been demonstrated by quantitative sensory testing as being associated with small-fiber (Aδ- and C-fiber) deafferentation. We aimed to compare laser stimulation (rad...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.04.029
更新日期:2012-08-01 00:00:00
abstract::A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.10.001
更新日期:2005-01-01 00:00:00
abstract::Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from pain research units exp...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000000433
更新日期:2016-03-01 00:00:00
abstract::Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.08.011
更新日期:2012-12-01 00:00:00
abstract:ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002195
更新日期:2021-01-12 00:00:00
abstract::The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00401-8
更新日期:2002-02-01 00:00:00
abstract::To date, patients with bony metastases were only a small fraction of the samples studied, or they were entirely excluded. Patients with metastatic cancers, such as bone metastases, are more likely to report pain, compared to patients without metastatic cancer (50-74% and 15%, respectively). Their cancer pain results i...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.06.021
更新日期:2011-10-01 00:00:00
abstract::Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00113-4
更新日期:1998-10-01 00:00:00