Abstract：
:The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and the 2nd phase (20-30 min) of the formalin test, and increased the duration of the response. The increase in the response to formalin depended on the formalin concentration and was significant with 1% and 5% concentrations of formalin but not with a 0.05% concentration. No increase in the response was observed when NMDA or substance P was given alone. These findings indicate that concurrent activation of spinal NMDA and substance P receptors induces an enhancement of spinal transmission of nociception, and that this enhancement is dependent on the intensity or the quality of the peripheral stimulus.
journal_name
Painjournal_title
Painauthors
Mjellem-Joly N,Lund A,Berge OG,Hole Kdoi
10.1016/0304-3959(92)90260-Ikeywords:
subject
Has Abstractpub_date
1992-11-01 00:00:00pages
195-198issue
2eissn
0304-3959issn
1872-6623pii
00006396-199211000-00008journal_volume
51pub_type
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