Abstract:
:Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve injury, which enables Aβ afferents to access pain pathways. However, a recent mouse knockout study demonstrates that C-tactile afferents are necessary for allodynia to develop, suggesting a role for not only Aβ but also C-tactile afferent signaling. To examine the contribution of C-tactile afferents to the allodynic condition in humans, we applied the heat/capsaicin model of tactile allodynia in 43 healthy subjects and in 2 sensory neuronopathy patients lacking Aβ afferents. Healthy subjects reported tactile-evoked pain, whereas the patients did not. Instead, patients reported their C-touch percept (faint sensation of pleasant touch) to be significantly weaker in the allodynic zone compared to untreated skin. Functional magnetic resonance imaging in 18 healthy subjects and in 1 scanned patient indicated that stroking in the allodynic and control zones evoked different responses in the primary cortical receiving area for thin fiber signaling, the posterior insular cortex. In addition, reduced activation in the medial prefrontal cortices, key areas for C-tactile hedonic processing, was identified. These findings suggest that dynamic tactile allodynia is associated with reduced C-tactile mediated hedonic touch processing. Nevertheless, because the patients did not develop allodynic pain, this seems dependent on Aβ signaling, at least under these experimental conditions.
journal_name
Painjournal_title
Painauthors
Liljencrantz J,Björnsdotter M,Morrison I,Bergstrand S,Ceko M,Seminowicz DA,Cole J,Bushnell CM,Olausson Hdoi
10.1016/j.pain.2012.10.024subject
Has Abstractpub_date
2013-02-01 00:00:00pages
227-234issue
2eissn
0304-3959issn
1872-6623pii
00006396-201302000-00011journal_volume
154pub_type
杂志文章相关文献
PAIN文献大全abstract::Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002100
更新日期:2020-09-30 00:00:00
abstract::The assessment and development of pain in children is reviewed in the first part of a two-part series. Assessment of pain in children has relied on self-report measures that have included visual analogue procedures using concrete stimuli for ratings. Behavioral assessment procedures are more sophisticated, but researc...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(86)90206-X
更新日期:1986-11-01 00:00:00
abstract::Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000690
更新日期:2016-12-01 00:00:00
abstract::Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical and cold sensitivity in neuropathic pain and therefore offered a new a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000197
更新日期:2015-08-01 00:00:00
abstract::Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000827
更新日期:2017-04-01 00:00:00
abstract::Experimental evidence is reviewed showing that brain and spinal cord serotonergic neurons are involved in nociceptive responses, as well as in the analgesic effects of opiate narcotics. This evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervo...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(77)90083-5
更新日期:1977-10-01 00:00:00
abstract::This study aimed to identify areas of disagreement in the management of neurogenic pain. A short questionnaire was mailed to 179 consultants with an interest in chronic pain (response rate 89%). The questionnaire listed 11 specific conditions involving nerve pain (e.g., post-herpetic neuralgia, causalgia) together wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90035-N
更新日期:1993-09-01 00:00:00
abstract::A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.10.001
更新日期:2005-01-01 00:00:00
abstract::The GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission was studied from young rat substantia gelatinosa (SG) neurons using a conventional whole-cell patch clamp technique. Action potential-dependent glycinergic inhibitory postsynaptic currents (IPSCs) were recorded from SG neurons in the pres...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.005
更新日期:2008-08-31 00:00:00
abstract::Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.025
更新日期:2008-07-01 00:00:00
abstract::Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system. A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development and maintenance of MS-relate...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001483
更新日期:2019-05-01 00:00:00
abstract::Although calcitonin gene-related peptide (CGRP) has been shown to be elevated in jugular venous blood of adult migraineurs during acute migraine attacks, it remains unknown whether CGRP is increased outside of attacks in jugular or cubital venous blood. The aim of the present study was to compare interictal plasma lev...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(00)00232-3
更新日期:2000-05-01 00:00:00
abstract::Colonoscopy is an invaluable tool for the screening and diagnosis of many colonic diseases. For most colonoscopies, moderate sedation is used during the procedure. However, insufflation of the colon produces a nociceptive stimulus that is usually accompanied by facial grimacing/groaning while under sedation. The objec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000446
更新日期:2016-04-01 00:00:00
abstract::Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded on previous findings related to the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001578
更新日期:2019-08-01 00:00:00
abstract::Pain is generally considered to have a sensory and an affective component. Clinical research has suggested that morphine more potently attenuates the affective component as compared to the sensory component. Because preclinical nociception models typically focus on the sensory component of nociception, and do not asse...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.07.027
更新日期:2008-06-01 00:00:00
abstract::Past research has shown that pain catastrophizing contributes to heightened pain experience. The hypothesis advanced in this study was that individuals who score high on measures of pain catastrophizing would also perceive more intense pain in others. The study also examined the role of pain behaviour as a determinant...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.02.007
更新日期:2006-07-01 00:00:00
abstract::Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(97)00034-1
更新日期:1997-08-01 00:00:00
abstract::The aim of this study was to investigate the relationship between psychosocial work characteristics and neck and upper limb symptoms and to examine to what extent this relationship could be explained by other risk factors. Data were used from a prospective cohort study in a working population, with a follow-up period ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.008
更新日期:2005-03-01 00:00:00
abstract::Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of a...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001322
更新日期:2018-11-01 00:00:00
abstract::Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(98)00201-2
更新日期:1999-03-01 00:00:00
abstract::Previous research has demonstrated that intravenously administered cannabinoids produce potent antinociception in rodents. The present study examined the ability of 16 cannabinoid analogs to produce antinociception and hypothermia after intrathecal administration. Fifteen of the compounds tested produced significant i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90004-U
更新日期:1992-10-01 00:00:00
abstract::Phantom urinary phenomena are a relatively rare disease entity. Literature search has revealed only one case following cystectomy, seven cases following spinal cord injury and several other cases in hemodialysis patients. This report presents a case of painful phantom bladder following cystectomy for chronic kidney an...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90011-3
更新日期:1979-10-01 00:00:00
abstract::Peripheral nerve injury produces a persistent neuropathic pain state characterized by spontaneous pain, allodynia and hyperalgesia. In this study, we evaluated the possible involvement of A 2ARs in the development of neuropathic pain and the expression of microglia and astrocytes in the spinal cord after sciatic nerve...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.07.012
更新日期:2008-11-15 00:00:00
abstract::Twenty patients with chronic low back pain received 12 lumbar sympathetic injections, in a series of 6 with bupivacaine and a series of 6 with saline. Changes in subjective pain intensity, EMG from paravertebral muscles, joint ranges of mobility, and daily activity levels were measured at multiple intervals throughout...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(80)90085-8
更新日期:1980-02-01 00:00:00
abstract::Unlike most classical analgesics, botulinum toxin type A (BoNT/A) does not alter acute nociceptive thresholds, and shows selectivity primarily for allodynic and hyperalgesic responses in certain pain conditions. We hypothesized that this phenomenon might be explained by characterizing the sensory neurons targeted by B...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.04.027
更新日期:2014-08-01 00:00:00
abstract::The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00026-X
更新日期:2002-08-01 00:00:00
abstract::Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00315-4
更新日期:2003-11-01 00:00:00
abstract::Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00092-5
更新日期:1996-01-01 00:00:00
abstract::We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history, examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00244-4
更新日期:2000-02-01 00:00:00
abstract:ABSTRACT:Mobile health (mHealth) apps have the potential to enhance pain management through the use of daily diaries, medication and appointment reminders, education, and facilitating communication between patients and providers. Although many pain management apps exist, the extent to which these apps use evidence-base...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002090
更新日期:2020-09-22 00:00:00