Abstract:
:Patients with chronic pain often report being sensitive to pain at night before falling asleep, a time when the synchronization of cortical activity is initiated. However, how cortical activity relates to pain sensitivity is still unclear. Because sleep is characterized by enhanced cortical delta power, we hypothesized that enhanced cortical delta power may be an indicator of intensified pain. To test this hypothesis, we used pain thresholds tests, EEG/electromyogram recordings, c-Fos staining, and chemogenetic and pharmacological techniques in mice. We found that sleep deprivation or pharmacologic enhancement of EEG delta power by reserpine and scopolamine dramatically decreased mechanical pain thresholds, but not thermal withdrawal latency, in a partial sciatic nerve ligation model of neuropathic pain mice. On the contrary, suppression of EEG delta power using a wake-promoting agent modafinil significantly attenuated mechanical allodynia. Moreover, when EEG delta power was enhanced, c-Fos expression decreased in most regions of the cortex, except the anterior cingulate cortex (ACC), where c-Fos was increased in the somatostatin- and parvalbumin-positive GABAergic neurons. Chemogenetic activation of GABAergic neurons in ACC enhanced EEG delta power and lowered mechanical pain thresholds simultaneously in naive mice. However, chemogenetic inhibition of ACC GABAergic neurons could not block mechanical allodynia. These results provided compelling evidence that elevated EEG delta power is accompanied with aggravated neuropathic pain, whereas decreased delta power attenuated it, suggesting that enhanced delta power can be a specific marker of rising chronic neuropathic pain and that wake-promoting compounds could be used as analgesics in the clinic.
journal_name
Painjournal_title
Painauthors
Li YD,Ge J,Luo YJ,Xu W,Wang J,Lazarus M,Hong ZY,Qu WM,Huang ZLdoi
10.1097/j.pain.0000000000001725subject
Has Abstractpub_date
2020-02-01 00:00:00pages
288-299issue
2eissn
0304-3959issn
1872-6623pii
00006396-202002000-00007journal_volume
161pub_type
杂志文章相关文献
PAIN文献大全abstract::The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90028-A
更新日期:1992-09-01 00:00:00
abstract::In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.07.035
更新日期:2013-11-01 00:00:00
abstract::A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in lumbar disc herniation. In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniatio...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00068-4
更新日期:2002-09-01 00:00:00
abstract::Pain patients' retrospective reports of pain are important to physicians and other health professionals in helping to decide on future treatment plans. Unfortunately patients' memory of pain can be inaccurate and subject to overestimation. This study examined variables which influenced accuracy of remembering pain in ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90193-0
更新日期:1989-06-01 00:00:00
abstract::Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.08.003
更新日期:2004-11-01 00:00:00
abstract::Pain and thermal sensitivity thresholds in healthy volunteers were examined for diurnal variations. The subjects were 11 men aged between 22 and 27 years (means = 23.5, S.D. = 1.5). Data were collected for 2 days, with 7 measurements per day. To ensure the pain specificity of the results the subliminal modality, i.e.,...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90120-6
更新日期:1989-01-01 00:00:00
abstract::This study examined the adaptational classification stability of the multidimensional pain inventory (MPI) in two samples of female fibromyalgia syndrome patients. Retest resulted in one-third of patients being assigned to a different classification. Twenty patients had four repeated MPI assessments over a 10-month pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.01.014
更新日期:2004-05-01 00:00:00
abstract::There are few prospective studies assessing risk factors for onset of temporomandibular (TMD) pain disorders in any age group. The aim of this prospective cohort study was to identify risk factors for onset of clinically significant TMD pain (i.e., pain meeting research diagnostic criteria for myofascial pain and/or a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.10.012
更新日期:2007-06-01 00:00:00
abstract::Regular physical activity in healthy individuals prevents development of chronic musculoskeletal pain; however, the mechanisms underlying this exercise-induced analgesia are not well understood. Interleukin-10 (IL-10), an antiinflammatory cytokine that can reduce nociceptor sensitization, increases during regular phys...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000312
更新日期:2016-01-01 00:00:00
abstract::Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.002
更新日期:2009-08-01 00:00:00
abstract::To characterize the contribution of interleukin-6 (IL-6) to spinal cord injury pain (SCIP), we employed a clinically relevant rat contusion model of SCIP. Using Western blots, we measured IL-6 levels in lumbar segments (L1-L5), at the lesion site (T10), and in the corresponding lumbar and thoracic dorsal root ganglia ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.03.026
更新日期:2013-07-01 00:00:00
abstract::Hindlimb pain models developed in rats have been transposed to mice, but assumed sciatic nerve neuroanatomic similarities have not been examined. We compared sciatic nerve structural organization in mouse strains (C57BL/6J, DBA/2J, and B6129PF2/J) and rat strains (Wistar, Brown Norway, and Sprague-Dawley). Dissection ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.016
更新日期:2008-05-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000831
更新日期:2017-04-01 00:00:00
abstract::Numerous medications prolong the rate-corrected QT (QTc) interval and induce arrhythmias by blocking ionic current through cardiac potassium channels composed of subunits expressed by the human ether-a-go-go-related gene (HERG). Recent reports suggest that high doses of methadone cause torsades de pointes. To date, no...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00205-7
更新日期:2003-10-01 00:00:00
abstract::Tanezumab is a humanized monoclonal antinerve growth factor antibody in development for treatment of chronic pain. In a phase III, placebo- and active-controlled study, we investigated the efficacy and safety of tanezumab for osteoarthritis (OA) hip or knee pain. Patients (N=610) received up to 2 doses of intravenous ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.04.035
更新日期:2013-09-01 00:00:00
abstract::Capture-recapture methods are increasingly used to determine the prevalence of numerous chronic conditions but have never been used in the context of chronic pain (CP). This study sought to provide up-to-date estimates of the prevalence of people experiencing CP ± neuropathic characteristics in France using the captur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001347
更新日期:2018-11-01 00:00:00
abstract::This study analyzed the relationship between the density of intraepidermal nerve fibers (IENF) and the characteristics of either nociceptive laser-evoked potentials (LEPs) or contact heat-evoked potentials (CHEPs) in patients with painful sensory polyneuropathy with the aim to determine which parameters of LEPs and CH...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.11.012
更新日期:2011-02-01 00:00:00
abstract::This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.12.018
更新日期:2012-04-01 00:00:00
abstract::Physicians are frequently called upon to evaluate patients with chronic pain to (1) establish the etiology, (2) determine the extent of impairment and disability, and (3) prescribe treatment. In many cases, there is little agreement as to what evaluation procedures should be used or how to weight and integrate these f...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90181-9
更新日期:1988-07-01 00:00:00
abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2004.06.013
更新日期:2004-09-01 00:00:00
abstract::The effects of vibratory stimulation on muscular pain threshold were investigated in 28 healthy subjects. Pain sensation was evaluated by the subjects' verbal reports in response to electrical stimulation of the vastus medialis muscle. Concomitant variations of blink response evoked as a component of the startle react...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90046-1
更新日期:1986-02-01 00:00:00
abstract::Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460350.30707.8d
更新日期:2015-04-01 00:00:00
abstract::Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001459
更新日期:2019-04-01 00:00:00
abstract::The endogenous opioid peptide dynorphin A has non-opioid effects that can damage the spinal cord when given in high doses. Dynorphin has been shown to increase the receptive field size of spinal cord neurons and facilitate C-fiber-evoked reflexes. Furthermore, endogenous dynorphin levels increase following damage to t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00046-8
更新日期:1997-08-01 00:00:00
abstract::The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90083-0
更新日期:1983-05-01 00:00:00
abstract::We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(02)00334-2
更新日期:2003-02-01 00:00:00
abstract::The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (c...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2006.04.031
更新日期:2006-10-01 00:00:00
abstract::The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(88)90156-X
更新日期:1988-08-01 00:00:00
abstract::For many individuals undergoing routine surgical procedures, their satisfaction with the operation may depend upon their postoperative experience. We used the McGill Pain Questionnaire and the McGill Nausea Questionnaire to study the intensity of 5 common postoperative problems--sore throat, muscle pain, headache, bac...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90040-7
更新日期:1989-12-01 00:00:00
abstract::The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00021-3
更新日期:1997-09-01 00:00:00