On the relationship between nociceptive evoked potentials and intraepidermal nerve fiber density in painful sensory polyneuropathies.

abstract：:Internet-based educational and therapeutic programs (e-health applications) are becoming increasingly popular for a variety of psychological and physical disorders. We tested the efficacy of an online Chronic Pain Management Program, a comprehensive, fully self-directed and self-paced system that integrates social net...

journal_title：Pain

authors： Ruehlman LS,Karoly P,Enders C

更新日期：2012-02-01 00:00:00

abstract：:Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...

journal_title：Pain

authors： Taiwo OB,Taylor BK

更新日期：2002-04-01 00:00:00

abstract：:microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...

journal_title：Pain

authors： Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger E

更新日期：2013-03-01 00:00:00

abstract：:Advances in pain measurement using ecological momentary assessments offer novel opportunities for understanding the temporal dynamics of pain. This study examined whether regime-switching models, which capture processes characterized by recurrent shifts between different states, provide clinically relevant information...

journal_title：Pain

authors： Schneider S,Junghaenel DU,Ono M,Stone AA

更新日期：2018-07-01 00:00:00

abstract：:This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 150 mg/kg (75 mg/kg intraperitoneal on 2 successive days). When compare...

journal_title：Pain

authors： Zurek JR,Nadeson R,Goodchild CS

更新日期：2001-02-01 00:00:00

abstract：:The experiments determined the ventilatory effects of epidurally injected morphine and sufentanil in rats in the absence and in the presence of chlordiazepoxide, a drug that may alleviate the effects of stress. Soon after administration of morphine as well as of sufentanil, ventilation was more profoundly depressed wh...

journal_title：Pain

authors： Van den Hoogen RHWM,Bervoets KJW,Colpaert FC

更新日期：1989-04-01 00:00:00

abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...

journal_title：Pain

authors： Hardy PAJ,Wells JCD

更新日期：1989-02-01 00:00:00

abstract：:Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...

journal_title：Pain

authors： Shields SD,Mazario J,Skinner K,Basbaum AI

更新日期：2007-09-01 00:00:00

abstract：:Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precise cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test the...

journal_title：Pain

authors： Thomaidou MA,Veldhuijzen DS,Meulders A,Evers AWM

更新日期：2021-01-01 00:00:00

abstract：:Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...

journal_title：Pain

authors： Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

更新日期：2020-09-30 00:00:00

abstract：:The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...

journal_title：Pain

authors： Bragin EO,Vasilenko GF,Durinjan RA

更新日期：1983-05-01 00:00:00

abstract：:Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...

journal_title：Pain

authors： Laughlin TM,Bethea JR,Yezierski RP,Wilcox GL

更新日期：2000-02-01 00:00:00

abstract：:Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...

journal_title：Pain

authors： Gibson SJ,Helme RD

更新日期：2000-04-01 00:00:00

abstract：:Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy (DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP, assess screening tools for NeuP, and relate DPN severity to NeuP. The Pain in Neuropathy Study (PiNS) is an observational cross-sectional multi...

journal_title：Pain

authors： Themistocleous AC,Ramirez JD,Shillo PR,Lees JG,Selvarajah D,Orengo C,Tesfaye S,Rice ASC,Bennett DLH

更新日期：2016-05-01 00:00:00

abstract：:Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...

journal_title：Pain

authors： Ziegeler C,Schulte LH,May A

更新日期：2020-10-26 00:00:00

abstract：:The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...

journal_title：Pain

authors： Morasco BJ,Smith N,Dobscha SK,Deyo RA,Hyde S,Yarborough BJH

更新日期：2020-06-01 00:00:00

abstract：:The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...

journal_title：Pain

authors： Leinisch E,Evers S,Kaempfe N,Kraemer C,Sostak P,Jürgens T,Straube A,May A

更新日期：2005-10-01 00:00:00

abstract：:High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...

journal_title：Pain

authors： Cornelius VR,Sauzet O,Williams JE,Ayis S,Farquhar-Smith P,Ross JR,Branford RA,Peacock JL

更新日期：2013-02-01 00:00:00

abstract：:Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...

journal_title：Pain

authors： Noppers IM,Niesters M,Aarts LPHJ,Bauer MCR,Drewes AM,Dahan A,Sarton EY

更新日期：2011-09-01 00:00:00

abstract：:Our objectives were to determine whether procedural pain and glucose exposure are associated with altered structural and functional brain development differently in preterm males and females, and neurodevelopment at 18-month corrected age. Fifty-one very preterm neonates (22 males; median [interquartile range] gestati...

journal_title：Pain

authors： Schneider J,Duerden EG,Guo T,Ng K,Hagmann P,Bickle Graz M,Grunau RE,Chakravarty MM,Hüppi PS,Truttmann AC,Miller SP

更新日期：2018-03-01 00:00:00

abstract：:The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined. Buspirone produced dose- and time-dependent analgesia in all nociceptive tests, with greatest effects against chemical and mechanical pain. Buspirone was less po...

journal_title：Pain

authors： Giordano J,Rogers L

更新日期：1989-10-01 00:00:00

abstract：:In inflammatory neuropathy, immune activation near intact peripheral nerves induces mechanical allodynia. The identity of the peripheral immune product(s) that lead to these changes in pain behavior is unknown. The present series of studies utilized the sciatic inflammatory neuropathy (SIN) model to examine this quest...

journal_title：Pain

authors： Twining CM,Sloane EM,Milligan ED,Chacur M,Martin D,Poole S,Marsh H,Maier SF,Watkins LR

更新日期：2004-07-01 00:00:00

abstract：:The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...

journal_title：Pain

authors： Svendsen F,Rygh LJ,Hole K,Tjølsen A

更新日期：1999-12-01 00:00:00

abstract：:In the last decade, there has been burgeoning interest in the effectiveness of third-generation psychological therapies for managing fibromyalgia (FM) symptoms. The present study examined the effectiveness of acceptance and commitment therapy (ACT) on functional status as well as the role of pain acceptance as a media...

journal_title：Pain

authors： Luciano JV,Guallar JA,Aguado J,López-Del-Hoyo Y,Olivan B,Magallón R,Alda M,Serrano-Blanco A,Gili M,Garcia-Campayo J

更新日期：2014-04-01 00:00:00

abstract：:This study evaluated two brief (3-5 min) interventions for controlling responses to acute pain. Eighty male subjects were randomly assigned to 1 of 2 intervention groups (Positive Emotion Induction (PEI) or Brief Relaxation (BR)) or to 1 of 2 control groups (No-instruction or Social Demand). The PEI focused on re-crea...

journal_title：Pain

authors： Bruehl S,Carlson CR,McCubbin JA

更新日期：1993-07-01 00:00:00

abstract：:Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...

journal_title：Pain

authors： Bernfort L,Gerdle B,Rahmqvist M,Husberg M,Levin LÅ

更新日期：2015-03-01 00:00:00

abstract：:Part I of our earlier pilot study demonstrated that patients preferred modulated stimulation forms - frequency modulation and burst - rather than conventional continuous mode. To assess whether long-term therapeutic effects validate the immediate test results, this trial was performed in 14 patients with 21 pain condi...

journal_title：Pain

authors： Tulgar M,McGlone F,Bowsher D,Miles JB

更新日期：1991-11-01 00:00:00

abstract：:The present study utilized recently developed diagnostic tests that permit recognition of functional deficits in spine mobility, trunk strength, endurance, coordination, and dynamic lifting capacity. Changes in these tests were compared to changes in psychological functioning (e.g., self-report of pain) as well as to ...

journal_title：Pain

authors： Mayer TG,Gatchel RJ,Kishino N,Keeley J,Mayer H,Capra P,Mooney V

更新日期：1986-04-01 00:00:00

abstract：:Intrathecal (i.t.) administration of spermine (0.1-10000 fmol), an endogenous polyamine, produced the behavioural response mainly consisting of biting and/or licking of the hindpaw along with a slight hindlimb scratching directed toward the flank in mice, which peaked at 5-15 min and almost disappeared at 30 min after...

journal_title：Pain

authors： Tan-No K,Taira A,Wako K,Niijima F,Nakagawasai O,Tadano T,Sakurada C,Sakurada T,Kisara K

更新日期：2000-05-01 00:00:00

abstract：:Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...

journal_title：Pain

authors： Beasley M,Freidin MB,Basu N,Williams FMK,Macfarlane GJ

更新日期：2019-02-01 00:00:00