Abstract：
:Thirty subjects were given a placebo (intravenous saline), which was described as a known pain killer, once a week for 3 consecutive weeks. Experimental ischemic arm pain was produced prior to the placebo and again 1 h later. In a double blind procedure, half of the subjects received 10 mg of naloxone after placebo; the remaining subjects received naloxone vehicle. In addition to the placebo session, there were control and naloxone sessions each week to determine the normal changes in pain and the effect of naloxone on the pain, respectively, when no placebo was given. Significant placebo-induced analgesia was demonstrated, and a group of consistent placebo responders was identified. Although naloxone alone had no effect on the experimental pain, naloxone diminished the analgesic effectiveness of the placebo, suggesting that endogenous opioids are involved in producing placebo-induced analgesia.
journal_name
Painjournal_title
Painauthors
Grevert P,Albert LH,Goldstein Adoi
10.1016/0304-3959(83)90203-8subject
Has Abstractpub_date
1983-06-01 00:00:00pages
129-143issue
2eissn
0304-3959issn
1872-6623pii
00006396-198306000-00003journal_volume
16pub_type
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