Abstract：
:The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were placed in the masseter and digastric muscles and a light was attached to the mandibular symphysis to track jaw movements. The animals were decerebrated and the anesthetic was discontinued. Rhythmic jaw movements were evoked by electrically stimulating the corticobulbar tracts (1-msec rectangular pulses, 50 Hz), in the absence and presence of tonic noxious pressure applied bilaterally to the zygomatic periosteum (range: 400-1500 kPa). The overall response to tonic noxious pressure was a statistically significant decrease in the frequency and amplitude of the rhythmic jaw movements and in the mandibular velocity during opening and closing. The slowing of the frequency was associated with a significant increase in the duration between muscle bursts. In those animals in which the jaw closing muscles were most active, there was a significant decrease in the area of the masseter muscle bursts during jaw closure. The changes in motor activity in response to the application of tonic noxious pressure are similar to those that have been reported for patients experiencing musculoskeletal pain, suggesting that pain modifies motor programs at the segmental level. Our data support the pain-adaptation model.
journal_name
Painjournal_title
Painauthors
Schwartz G,Lund JPdoi
10.1016/0304-3959(95)00028-Qsubject
Has Abstractpub_date
1995-11-01 00:00:00pages
153-161issue
2eissn
0304-3959issn
1872-6623pii
00006396-199511000-00003journal_volume
63pub_type
杂志文章相关文献
PAIN文献大全abstract：:Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.07.021
更新日期：2011-11-01 00:00:00
abstract：:Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.07.012
更新日期：2012-10-01 00:00:00
abstract：:The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000778
更新日期：2017-03-01 00:00:00
abstract：:Ectopically generated and antidromically conducted nerve impulses were recorded in 5 patients with tungsten microelectrodes inserted into skin nerve fascicles. All patients had mainly positive sensory symptoms and reported paresthesiae which could be provoked by different maneuvers which suggested increased mechanosen...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90013-7
更新日期：1984-11-01 00:00:00
abstract：:Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00318-9
更新日期：2001-09-01 00:00:00
abstract：:Interactions between the input from cutaneous and nociceptive muscle afferents in polysynaptic reflex pathways were investigated in man. Interaction was tested by evoking reflexes before, during, and after a period of muscle pain induced by intramuscular injection of hypertonic saline. Muscle pain was induced either i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(99)00174-8
更新日期：2000-01-01 00:00:00
abstract：:This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(97)00126-7
更新日期：1997-12-01 00:00:00
abstract：:Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.018
更新日期：2007-04-01 00:00:00
abstract：:Although cognitive-behavioral therapies (CBT) have been demonstrated to be effective for a variety of chronic pain problems, patients vary in their response and little is known about patient characteristics that predict or moderate treatment effects. Furthermore, although cognitive-behavioral theory posits that change...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2006.09.005
更新日期：2007-02-01 00:00:00
abstract：:A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(85)90174-5
更新日期：1985-06-01 00:00:00
abstract：:Changes in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001366
更新日期：2018-12-01 00:00:00
abstract：:Gabapentin is an effective option for the treatment of neuropathic pain syndromes because of its efficacy and favorable side-effect profile. A case is presented of a 58 year old man who developed a painful polyneuropathy while being treated with gabapentin. ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)00188-7
更新日期：1998-02-01 00:00:00
abstract：:The purpose of this study was to assess if the functional activation caused by painful stimuli could be detected with arterial spin labeling (ASL), which is a non-invasive magnetic resonance imaging (MRI) technique for measuring cerebral blood flow (CBF). Because ASL directly measures blood flow, it is well suited to ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.06.021
更新日期：2008-05-01 00:00:00
abstract：:Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2014.01.008
更新日期：2014-04-01 00:00:00
abstract：:A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(85)90010-7
更新日期：1985-12-01 00:00:00
abstract：:Spiritual healing is a popular complementary and alternative therapy; in the UK almost 13000 members are registered in nine separate healing organisations. The present randomized clinical trial was designed to investigate the efficacy of healing in the treatment of chronic pain. One hundred and twenty patients sufferi...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(00)00421-8
更新日期：2001-03-01 00:00:00
abstract：:Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(98)00201-2
更新日期：1999-03-01 00:00:00
abstract：:The inability of opioids to control pain over time may be influenced by different factors such as drug tolerance, hyperalgesia due to repeated morphine administration or progression of the original disease. In addition, chronic pain may alter morphine tolerance development. This study examined whether chronic morphine...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00334-1
更新日期：2000-12-01 00:00:00
abstract：:Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed. Systematic literature reviews, randomized clinical trials, and existing guidelines were evaluated at a consensus meeting. Medications were considered for recommendation if ...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/j.pain.2007.08.033
更新日期：2007-12-05 00:00:00
abstract：:The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90118-U
更新日期：1992-07-01 00:00:00
abstract：:We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(02)00334-2
更新日期：2003-02-01 00:00:00
abstract：:Chronic pain was induced in rats by daily injections of complete Freund's adjuvant into hind paws. Daily changes of pain threshold and endorphin (ED) content and their receptors in 4 divided parts: cortex, diencephalon-mesencephalon containing striatum (D-M), pons-medulla (P-M) and spinal cord, were measured. Decrease...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90131-8
更新日期：1983-09-01 00:00:00
abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90023-7
更新日期：1989-02-01 00:00:00
abstract：:The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001350
更新日期：2018-12-01 00:00:00
abstract：:Sensory neuron-specific receptors (SNSRs) belong to a large family of GPCRs, known as Mrgs (Mas-related genes), many of which are preferentially expressed in primary afferent nociceptors. Selective SNSR agonists produce pain-like behaviors in rats, showing that SNSR activation is sufficient to produce pain. However, i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.02.010
更新日期：2009-05-01 00:00:00
abstract：:The aim of the present study has been to assess the responsiveness of various types of chronic pain to opioids given i.v. and tested against placebo in a double-blind, randomized fashion. Pain classified as primary nociceptive was effectively alleviated (P greater than 0.001) while neuropathic deafferentation pain was...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(88)90198-4
更新日期：1988-04-01 00:00:00
abstract：:Spasticity is a major clinical manifestation of spinal cord injury and upper motor neuron syndrome. ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(99)00255-9
更新日期：2000-03-01 00:00:00
abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)00018-3
更新日期：1997-08-01 00:00:00
abstract：:Although systemic lidocaine has been shown to suppress postoperative pain in a clinical setting, the mechanisms of action of lidocaine have not been elucidated. The present study was therefore designed to determine the relative contribution of central and peripheral sites to the action of lidocaine on incision-induced...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.01.004
更新日期：2006-05-01 00:00:00
abstract：:Using the chronic constriction injury (CCI) model of neuropathic pain, we profiled gene expression in the rat spinal cord, and identified SIP30 as a gene whose expression was elevated after CCI. SIP30 was previously shown to interact with SNAP25, but whose function was otherwise unknown. We now show that in the spinal...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.07.011
更新日期：2009-11-01 00:00:00
