Abstract:
:The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were placed in the masseter and digastric muscles and a light was attached to the mandibular symphysis to track jaw movements. The animals were decerebrated and the anesthetic was discontinued. Rhythmic jaw movements were evoked by electrically stimulating the corticobulbar tracts (1-msec rectangular pulses, 50 Hz), in the absence and presence of tonic noxious pressure applied bilaterally to the zygomatic periosteum (range: 400-1500 kPa). The overall response to tonic noxious pressure was a statistically significant decrease in the frequency and amplitude of the rhythmic jaw movements and in the mandibular velocity during opening and closing. The slowing of the frequency was associated with a significant increase in the duration between muscle bursts. In those animals in which the jaw closing muscles were most active, there was a significant decrease in the area of the masseter muscle bursts during jaw closure. The changes in motor activity in response to the application of tonic noxious pressure are similar to those that have been reported for patients experiencing musculoskeletal pain, suggesting that pain modifies motor programs at the segmental level. Our data support the pain-adaptation model.
journal_name
Painjournal_title
Painauthors
Schwartz G,Lund JPdoi
10.1016/0304-3959(95)00028-Qsubject
Has Abstractpub_date
1995-11-01 00:00:00pages
153-161issue
2eissn
0304-3959issn
1872-6623pii
00006396-199511000-00003journal_volume
63pub_type
杂志文章相关文献
PAIN文献大全abstract::Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(99)00284-5
更新日期:2000-04-01 00:00:00
abstract::We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were inclu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001313
更新日期:2018-10-01 00:00:00
abstract::Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90085-X
更新日期:1984-08-01 00:00:00
abstract::Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(00)00483-8
更新日期:2001-05-01 00:00:00
abstract::In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spont...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90055-T
更新日期:1993-04-01 00:00:00
abstract::Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001426
更新日期:2019-02-01 00:00:00
abstract::The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.04.040
更新日期:2008-03-01 00:00:00
abstract::In several pain models, tricyclic antidepressants (TCAs) have been shown to reduce nociception. In the present study, we evaluated the antinociceptive effect of metapramine (META) in 4 nociception tests: (1) the hot plate test; (2) the phenylbenzoquinone-induced writhing; (3) the tail flick test; and (4) the test of e...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90167-9
更新日期:1987-12-01 00:00:00
abstract::The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00401-8
更新日期:2002-02-01 00:00:00
abstract::Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.025
更新日期:2008-07-01 00:00:00
abstract::Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000681
更新日期:2016-11-01 00:00:00
abstract::Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.03.026
更新日期:2011-09-01 00:00:00
abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91121-X
更新日期:1990-03-01 00:00:00
abstract::Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000890
更新日期:2017-06-01 00:00:00
abstract::It is well known that acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to acupuncture analgesia is less clear. One hundred one patients who developed pain of ≥ 3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive activ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.05.008
更新日期:2013-09-01 00:00:00
abstract::G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received little research attention. We used a tag singl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.08.026
更新日期:2013-12-01 00:00:00
abstract::Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000650
更新日期:2016-11-01 00:00:00
abstract::A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.04.022
更新日期:2012-10-01 00:00:00
abstract::Heterotopic noxious counterstimulation (HNCS) by the application of a sustained noxious stimulus has been shown to inhibit nociceptive processes and decrease pain induced by a competing noxious stimulus. However, it is still not clear how attentional processes contribute to these effects. The main objective of this st...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.05.019
更新日期:2012-08-01 00:00:00
abstract::Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recoveri...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00212-4
更新日期:2003-09-01 00:00:00
abstract::This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90082-M
更新日期:1992-03-01 00:00:00
abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2004.06.013
更新日期:2004-09-01 00:00:00
abstract::Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.06.001
更新日期:2004-09-01 00:00:00
abstract::The results of two experiments show that ratio scales of sensory and affective verbal pain descriptors are valid, reliable and objective. In the first experiment, 16 subjects rated 15 sensory and 15 affective verbal pain descriptors by numerical magnitude estimation and by cross-modality matching to handgrip force. Ra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90020-9
更新日期:1978-06-01 00:00:00
abstract::Adolescents with chronic pain are at risk for impairment in their friendships. They miss out on leisure activities, have increased school absence, may have fewer friends, are at an increased risk for victimization, and may be perceived by peers as less likeable. To help determine the source of these problems, the Soci...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.09.001
更新日期:2011-12-01 00:00:00
abstract::We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002144
更新日期:2020-11-11 00:00:00
abstract::Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.04.022
更新日期:2006-11-01 00:00:00
abstract::Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.024
更新日期:2012-08-01 00:00:00
abstract::Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00318-9
更新日期:2001-09-01 00:00:00
abstract::The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90141-W
更新日期:1992-05-01 00:00:00