Modification of rhythmical jaw movements by noxious pressure applied to the periosteum of the zygoma in decerebrate rabbits.


:The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were placed in the masseter and digastric muscles and a light was attached to the mandibular symphysis to track jaw movements. The animals were decerebrated and the anesthetic was discontinued. Rhythmic jaw movements were evoked by electrically stimulating the corticobulbar tracts (1-msec rectangular pulses, 50 Hz), in the absence and presence of tonic noxious pressure applied bilaterally to the zygomatic periosteum (range: 400-1500 kPa). The overall response to tonic noxious pressure was a statistically significant decrease in the frequency and amplitude of the rhythmic jaw movements and in the mandibular velocity during opening and closing. The slowing of the frequency was associated with a significant increase in the duration between muscle bursts. In those animals in which the jaw closing muscles were most active, there was a significant decrease in the area of the masseter muscle bursts during jaw closure. The changes in motor activity in response to the application of tonic noxious pressure are similar to those that have been reported for patients experiencing musculoskeletal pain, suggesting that pain modifies motor programs at the segmental level. Our data support the pain-adaptation model.






Schwartz G,Lund JP




Has Abstract


1995-11-01 00:00:00
















  • Cognitive factors and the experience of pain and suffering in older persons.

    abstract::Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...


    pub_type: 临床试验,杂志文章


    authors: Gibson SJ,Helme RD

    更新日期:2000-04-01 00:00:00

  • Patterns of recovery from pain after cesarean delivery.

    abstract::We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were inclu...


    pub_type: 杂志文章


    authors: Booth JL,Sharpe EE,Houle TT,Harris L,Curry RS,Aschenbrenner CA,Eisenach JC

    更新日期:2018-10-01 00:00:00

  • Site of pain: relationship to measures of pain description, behavior and personality.

    abstract::Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...


    pub_type: 杂志文章


    authors: Toomey TC,Gover VF,Jones BN

    更新日期:1984-08-01 00:00:00

  • A cross-national study of the course of persistent pain in primary care.

    abstract::Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...


    pub_type: 杂志文章


    authors: Gureje O,Simon GE,Von Korff M

    更新日期:2001-05-01 00:00:00

  • Dissociation of hypertension and enhanced clonidine-induced antinociception in spontaneously hypertensive rats.

    abstract::In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spont...


    pub_type: 杂志文章


    authors: Lin JC,Tsao WL,Lee HK,Wang Y

    更新日期:1993-04-01 00:00:00

  • What is the effect of alcohol consumption on the risk of chronic widespread pain? A Mendelian randomisation study using UK Biobank.

    abstract::Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...


    pub_type: 杂志文章


    authors: Beasley M,Freidin MB,Basu N,Williams FMK,Macfarlane GJ

    更新日期:2019-02-01 00:00:00

  • Peripheral involvement of PKA and PKC in subcutaneous bee venom-induced persistent nociception, mechanical hyperalgesia, and inflammation in rats.

    abstract::The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...


    pub_type: 杂志文章


    authors: Chen HS,Lei J,He X,Qu F,Wang Y,Wen WW,You HJ,Arendt-Nielsen L

    更新日期:2008-03-01 00:00:00

  • Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants.

    abstract::In several pain models, tricyclic antidepressants (TCAs) have been shown to reduce nociception. In the present study, we evaluated the antinociceptive effect of metapramine (META) in 4 nociception tests: (1) the hot plate test; (2) the phenylbenzoquinone-induced writhing; (3) the tail flick test; and (4) the test of e...


    pub_type: 杂志文章


    authors: Michael-Titus A,Costentin J

    更新日期:1987-12-01 00:00:00

  • The effects of excessive heat on heat-activated membrane currents in cultured dorsal root ganglia neurons from neonatal rat.

    abstract::The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...


    pub_type: 杂志文章


    authors: Lyfenko A,Vlachová V,Vyklický L,Dittert I,Kress M,Reeh PW

    更新日期:2002-02-01 00:00:00

  • Duration of sleep contributes to next-day pain report in the general population.

    abstract::Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...


    pub_type: 杂志文章


    authors: Edwards RR,Almeida DM,Klick B,Haythornthwaite JA,Smith MT

    更新日期:2008-07-01 00:00:00

  • The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.

    abstract::Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...


    pub_type: 杂志文章


    authors: Slosky LM,BassiriRad NM,Symons AM,Thompson M,Doyle T,Forte BL,Staatz WD,Bui L,Neumann WL,Mantyh PW,Salvemini D,Largent-Milnes TM,Vanderah TW

    更新日期:2016-11-01 00:00:00

  • Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases.

    abstract::Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...


    pub_type: 杂志文章,随机对照试验


    authors: Noppers IM,Niesters M,Aarts LPHJ,Bauer MCR,Drewes AM,Dahan A,Sarton EY

    更新日期:2011-09-01 00:00:00

  • Sensory and autonomic measurements in idiopathic trigeminal neuralgia before and after radiofrequency thermocoagulation: differentiation from some other causes of facial pain.

    abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...


    pub_type: 杂志文章


    authors: Hampf G,Bowsher D,Wells C,Miles J

    更新日期:1990-03-01 00:00:00

  • Determination of mild, moderate, and severe pain interference in patients with cancer.

    abstract::Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe...


    pub_type: 杂志文章


    authors: Shi Q,Mendoza TR,Dueck AC,Ma H,Zhang J,Qian Y,Bhowmik D,Cleeland CS

    更新日期:2017-06-01 00:00:00

  • Specifying the nonspecific components of acupuncture analgesia.

    abstract::It is well known that acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to acupuncture analgesia is less clear. One hundred one patients who developed pain of ≥ 3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive activ...


    pub_type: 杂志文章,随机对照试验


    authors: Vase L,Baram S,Takakura N,Yajima H,Takayama M,Kaptchuk TJ,Schou S,Jensen TS,Zachariae R,Svensson P

    更新日期:2013-09-01 00:00:00

  • Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

    abstract::G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received little research attention. We used a tag singl...


    pub_type: 杂志文章


    authors: Bruehl S,Denton JS,Lonergan D,Koran ME,Chont M,Sobey C,Fernando S,Bush WS,Mishra P,Thornton-Wells TA

    更新日期:2013-12-01 00:00:00

  • Disproportionate longer-term opioid use among U.S. adults with mood disorders.

    abstract::Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...


    pub_type: 杂志文章


    authors: Halbert BT,Davis RB,Wee CC

    更新日期:2016-11-01 00:00:00

  • Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system.

    abstract::A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct ...


    pub_type: 杂志文章


    authors: Shields SD,Ahn HS,Yang Y,Han C,Seal RP,Wood JN,Waxman SG,Dib-Hajj SD

    更新日期:2012-10-01 00:00:00

  • Top-down attentional modulation of analgesia induced by heterotopic noxious counterstimulation.

    abstract::Heterotopic noxious counterstimulation (HNCS) by the application of a sustained noxious stimulus has been shown to inhibit nociceptive processes and decrease pain induced by a competing noxious stimulus. However, it is still not clear how attentional processes contribute to these effects. The main objective of this st...


    pub_type: 杂志文章


    authors: Ladouceur A,Tessier J,Provencher B,Rainville P,Piché M

    更新日期:2012-08-01 00:00:00

  • Impact of CYP2D6 genotype on postoperative tramadol analgesia.

    abstract::Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recoveri...


    pub_type: 杂志文章


    authors: Stamer UM,Lehnen K,Höthker F,Bayerer B,Wolf S,Hoeft A,Stuber F

    更新日期:2003-09-01 00:00:00

  • Comparison of cognitive-behavioral group treatment and an alternative non-psychological treatment for chronic low back pain.

    abstract::This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...


    pub_type: 杂志文章


    authors: Nicholas MK,Wilson PH,Goyen J

    更新日期:1992-03-01 00:00:00

  • Manipulating presence influences the magnitude of virtual reality analgesia.

    abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...


    pub_type: 临床试验,杂志文章


    authors: Hoffman HG,Sharar SR,Coda B,Everett JJ,Ciol M,Richards T,Patterson DR

    更新日期:2004-09-01 00:00:00

  • Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.

    abstract::Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...


    pub_type: 杂志文章


    authors: Chacur M,Gutiérrez JM,Milligan ED,Wieseler-Frank J,Britto LR,Maier SF,Watkins LR,Cury Y

    更新日期:2004-09-01 00:00:00

  • Ratio scales of sensory and affective verbal pain descriptors.

    abstract::The results of two experiments show that ratio scales of sensory and affective verbal pain descriptors are valid, reliable and objective. In the first experiment, 16 subjects rated 15 sensory and 15 affective verbal pain descriptors by numerical magnitude estimation and by cross-modality matching to handgrip force. Ra...


    pub_type: 杂志文章


    authors: Gracely RH,McGrath P,Dubner R

    更新日期:1978-06-01 00:00:00

  • Social information processing in adolescents with chronic pain: my friends don't really understand me.

    abstract::Adolescents with chronic pain are at risk for impairment in their friendships. They miss out on leisure activities, have increased school absence, may have fewer friends, are at an increased risk for victimization, and may be perceived by peers as less likeable. To help determine the source of these problems, the Soci...


    pub_type: 杂志文章


    authors: Forgeron PA,McGrath P,Stevens B,Evans J,Dick B,Finley AG,Carlson T

    更新日期:2011-12-01 00:00:00

  • Reduction in movement-evoked pain and fatigue during initial 30-minute TENS treatment predicts TENS responders in women with fibromyalgia.

    abstract::We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...


    pub_type: 杂志文章


    authors: Vance CG,Zimmerman MB,Dailey DL,Rakel BA,Geasland KM,Chimenti RL,Williams JM,Golchha M,Crofford LJ,Sluka KA

    更新日期:2020-11-11 00:00:00

  • Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation.

    abstract::Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...


    pub_type: 杂志文章


    authors: Li CY,Zhang XL,Matthews EA,Li KW,Kurwa A,Boroujerdi A,Gross J,Gold MS,Dickenson AH,Feng G,Luo ZD

    更新日期:2006-11-01 00:00:00

  • EVENDOL, a new behavioral pain scale for children ages 0 to 7 years in the emergency department: design and validation.

    abstract::Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...


    pub_type: 杂志文章


    authors: Fournier-Charrière E,Tourniaire B,Carbajal R,Cimerman P,Lassauge F,Ricard C,Reiter F,Turquin P,Lombart B,Letierce A,Falissard B

    更新日期:2012-08-01 00:00:00

  • Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro.

    abstract::Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...


    pub_type: 杂志文章


    authors: Roza C,Reeh PW

    更新日期:2001-09-01 00:00:00

  • The effects of feedback and contingent reinforcement on the exercise behavior of chronic pain patients.

    abstract::The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...


    pub_type: 杂志文章


    authors: Geiger G,Todd DD,Clark HB,Miller RP,Kori SH

    更新日期:1992-05-01 00:00:00