Abstract:
:Chronic pain was induced in rats by daily injections of complete Freund's adjuvant into hind paws. Daily changes of pain threshold and endorphin (ED) content and their receptors in 4 divided parts: cortex, diencephalon-mesencephalon containing striatum (D-M), pons-medulla (P-M) and spinal cord, were measured. Decrease in pain responsiveness was observed in the adjuvant-injected group with concomitant increase of ED content in P-M and spinal cord. This decrease in pain responsiveness in the adjuvant-injected group was significantly different from that in the non-treated control group being partially reversed by naloxone. Furthermore, [3H]met-enkephalin binding sites increase in number in P-M of the adjuvant-injected group when maximal decrease of pain responsiveness was observed, returning to control level thereafter. Scatchard analysis revealed the increase of the low affinity binding site in P-M of the adjuvant-injected group. In cortex and D-M, on the other hand, ED content tended to decrease and no change was observed in number of [3H]met-enkephalin binding sites. These results indicate that the ED system in P-M and spinal cord may be more substantially involved in autoanalgesia than in cortex and D-M.
journal_name
Painjournal_title
Painauthors
Yonehara N,Kudo T,Iwatsubo K,Maeda S,Saito K,Inoki Rdoi
10.1016/0304-3959(83)90131-8subject
Has Abstractpub_date
1983-09-01 00:00:00pages
91-98issue
1eissn
0304-3959issn
1872-6623pii
00006396-198309000-00009journal_volume
17pub_type
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