Hyperbaric oxygen therapy in cluster headache.

abstract：:Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...

journal_title：Pain

authors： Macfarlane TV,Blinkhorn AS,Davies RM,Ryan P,Worthington HV,Macfarlane GJ

更新日期：2002-10-01 00:00:00

abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...

journal_title：Pain

authors： Eccleston C,Fisher E,Cooper TE,Grégoire MC,Heathcote LC,Krane E,Lord SM,Sethna NF,Anderson AK,Anderson B,Clinch J,Gray AL,Gold JI,Howard RF,Ljungman G,Moore RA,Schechter N,Wiffen PJ,Wilkinson NMR,Williams DG,Wood

更新日期：2019-08-01 00:00:00

abstract：:Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...

journal_title：Pain

authors： Byers MR,Neuhaus SJ,Gehrig JD

更新日期：1982-07-01 00:00:00

abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...

journal_title：Pain

authors： Ardid D,Guilbaud G

更新日期：1992-05-01 00:00:00

abstract：:Intrathecal administration of serotonin type 2 (5-HT(2)) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antial...

journal_title：Pain

authors： Obata H,Saito S,Sakurazawa S,Sasaki M,Usui T,Goto F

更新日期：2004-03-01 00:00:00

abstract：:Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase (COX) inhibition at both peripheral and central sites can contribute to the antihyperalgesic effects of NSAIDs, with the predominant clinical effect ...

journal_title：Pain

authors： Hodkinson DJ,Khawaja N,O'Daly O,Thacker MA,Zelaya FO,Wooldridge CL,Renton TF,Williams SCR,Howard MA

更新日期：2015-07-01 00:00:00

abstract：ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...

journal_title：Pain

authors： Solcà M,Krishna V,Young N,Deogaonkar M,Herbelin B,Orepic P,Mange R,Rognini G,Serino A,Rezai A,Blanke O

更新日期：2020-11-30 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...

journal_title：Pain

authors： Olivan-Blázquez B,Herrera-Mercadal P,Puebla-Guedea M,Pérez-Yus MC,Andrés E,Fayed N,López-Del-Hoyo Y,Magallon R,Roca M,Garcia-Campayo J

更新日期：2014-12-01 00:00:00

abstract：:This study determined whether opiates alter vascular components of inflammation (hyperthermia, edema and plasma extravasation) in addition to the suppression of hyperalgesia. Rats were administered carrageenan into one hind paw and saline into the other hind paw, followed by i.p. injection of morphine (0.2-5.0 mg/kg) ...

journal_title：Pain

authors： Joris J,Costello A,Dubner R,Hargreaves KM

更新日期：1990-10-01 00:00:00

abstract：:Numerous medications prolong the rate-corrected QT (QTc) interval and induce arrhythmias by blocking ionic current through cardiac potassium channels composed of subunits expressed by the human ether-a-go-go-related gene (HERG). Recent reports suggest that high doses of methadone cause torsades de pointes. To date, no...

journal_title：Pain

authors： Kornick CA,Kilborn MJ,Santiago-Palma J,Schulman G,Thaler HT,Keefe DL,Katchman AN,Pezzullo JC,Ebert SN,Woosley RL,Payne R,Manfredi PL

更新日期：2003-10-01 00:00:00

abstract：:A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg ...

journal_title：Pain

authors： Gimbel JS,Kivitz AJ,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2014-09-01 00:00:00

abstract：:Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action, ...

journal_title：Pain

authors： Xie JY,Chew LA,Yang X,Wang Y,Qu C,Wang Y,Federici LM,Fitz SD,Ripsch MS,Due MR,Moutal A,Khanna M,White FA,Vanderah TW,Johnson PL,Porreca F,Khanna R

更新日期：2016-09-01 00:00:00

abstract：:Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...

journal_title：Pain

authors： Edwards RR,Fillingim RB,Ness TJ

更新日期：2003-01-01 00:00:00

abstract：:The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...

journal_title：Pain

authors： Kunz M,Lautenbacher S,LeBlanc N,Rainville P

更新日期：2012-02-01 00:00:00

abstract：:The purpose of this study was to assess the hypothesis that pain and depression negatively impact the cognitive functioning of individuals with rheumatoid arthritis (RA). One hundred twenty-one community-dwelling RA patients (ages 34-84) completed a battery of cognitive tasks and multiple measures of pain and depressi...

journal_title：Pain

authors： Brown SC,Glass JM,Park DC

更新日期：2002-04-01 00:00:00

abstract：:In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...

journal_title：Pain

authors： Brennum J,Arendt-Nielsen L,Horn A,Secher NH,Jensen TS

更新日期：1993-01-01 00:00:00

abstract：:Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP release, but their vasoconstrictor properties limit thei...

journal_title：Pain

authors： Labastida-Ramírez A,Rubio-Beltrán E,Haanes KA,Chan KY,Garrelds IM,Johnson KW,Danser AHJ,Villalón CM,MaassenVanDenBrink A

更新日期：2020-05-01 00:00:00

abstract：:This study was designed to assess the role of calcitonin gene-related peptide (CGRP) and its receptor in the generation and maintenance of secondary mechanical allodynia and hyperalgesia induced by intradermal injection of capsaicin in rats. Paw withdrawal responses (PWRs) to von Frey hairs with different bending forc...

journal_title：Pain

authors： Sun RQ,Lawand NB,Willis WD

更新日期：2003-07-01 00:00:00

abstract：:There is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated assoc...

journal_title：Pain

authors： Quinn PD,Rickert ME,Franck J,Sariaslan A,Boersma K,Lichtenstein P,Larsson H,D'Onofrio BM

更新日期：2019-11-01 00:00:00

abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...

journal_title：Pain

authors： Staud R,Cannon RC,Mauderli AP,Robinson ME,Price DD,Vierck CJ Jr

更新日期：2003-03-01 00:00:00

abstract：:We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a...

journal_title：Pain

authors： Shabes P,Schloss N,Magerl W,Schmahl C,Treede RD,Baumgärtner U

更新日期：2016-01-01 00:00:00

abstract：:Pain scales using faces are commonly used tools for assessing pain in children capable of communicating. However, some children require other types of pain scales because they have difficulties in understanding faces pain scales. The goal of this study was to develop and validate the "Pain Block" concrete ordinal scal...

journal_title：Pain

authors： Jung JH,Lee JH,Kim DK,Jung JY,Chang I,Kwon H,Shin J,Paek SH,Oh S,Kwak YH

更新日期：2018-04-01 00:00:00

abstract：:There is considerable evidence to implicate N-methyl-D-aspartate (NMDA) receptor activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many of the effects of NMDA receptor activation appear to be ultimately mediated through production of nitric oxide (NO), recent reports have begun to d...

journal_title：Pain

authors： Meller ST,Gebhart GF

更新日期：1993-02-01 00:00:00

abstract：:In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pai...

journal_title：Pain

authors： Schmidt AJM

更新日期：1987-09-01 00:00:00

abstract：:Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...

journal_title：Pain

authors： Giamberardino MA,Berkley KJ,Iezzi S,de Bigontina P,Vecchiet L

更新日期：1997-06-01 00:00:00

abstract：:Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...

journal_title：Pain

authors： Groth R,Aanonsen L

更新日期：2002-11-01 00:00:00

abstract：:The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...

journal_title：Pain

authors： Haythornthwaite JA,Sieber WJ,Kerns RD

更新日期：1991-08-01 00:00:00

abstract：:A number of investigators have suggested that the generic classification temporomandibular disorders (TMD) may consist of several subsets of patients. Two primary factors are to be significant in discriminating subgroups, namely, presence or absence of TM joint abnormalities and psychological characteristics such as t...

journal_title：Pain

authors： Rudy TE,Turk DC,Zaki HS,Curtin HD

更新日期：1989-03-01 00:00:00

abstract：:Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...

journal_title：Pain

authors： Lilley CM,Craig KD,Grunau RE

更新日期：1997-08-01 00:00:00

abstract：:The effects of cold stress were studied on rats with unilaterally sectioned sciatic nerves. Behaviors suggestive of pain occurred in a number of these animals. These behaviors vanished when removing the rats from the stressful environment. Some severely painful syndromes in man might in part be due to mechanisms simil...

journal_title：Pain

authors： Wiesenfeld Z,Hallin RG

更新日期：1980-06-01 00:00:00