Nitric oxide (NO) and nociceptive processing in the spinal cord.

abstract：ABSTRACT:Mobile health (mHealth) apps have the potential to enhance pain management through the use of daily diaries, medication and appointment reminders, education, and facilitating communication between patients and providers. Although many pain management apps exist, the extent to which these apps use evidence-base...

journal_title：Pain

authors： Gamwell KL,Kollin SR,Gibler RC,Bedree H,Bieniak KH,Jagpal A,Tran ST,Hommel KA,Ramsey RR

更新日期：2020-09-22 00:00:00

abstract：:Existing estimates of sociodemographic disparities in chronic pain in the United States are based on cross-sectional data, often treat pain as a binary construct, and rarely test for nonresponse or other types of bias. This study uses 7 biennial waves of national data from the Health and Retirement Study (1998-2010; n...

journal_title：Pain

authors： Grol-Prokopczyk H

更新日期：2017-02-01 00:00:00

abstract：:The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...

journal_title：Pain

authors： Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

更新日期：2015-02-01 00:00:00

abstract：:Central pain following traumatic brain injury (TBI) has not been studied in depth. Our purpose was to conduct a systematic study of patients with TBI suffering from chronic central pain, and to describe the characteristics of the central pain. Groups were TBI patients with (TBIP) and without central pain (TBINP) and h...

journal_title：Pain

authors： Ofek H,Defrin R

更新日期：2007-10-01 00:00:00

abstract：:The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

journal_title：Pain

authors： Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

更新日期：1995-12-01 00:00:00

abstract：:A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression. Treatment was given, in randomized order, for periods of 4 weeks, separated by 1 week wash-o...

journal_title：Pain

authors： Leijon G,Boivie J

更新日期：1989-01-01 00:00:00

abstract：:This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 150 mg/kg (75 mg/kg intraperitoneal on 2 successive days). When compare...

journal_title：Pain

authors： Zurek JR,Nadeson R,Goodchild CS

更新日期：2001-02-01 00:00:00

abstract：:When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...

journal_title：Pain

authors： Seltzer Z,Cohn S,Ginzburg R,Beilin B

更新日期：1991-04-01 00:00:00

abstract：:Treatment of neuropathic pain is a major clinical challenge that has been met with minimal success. After peripheral nerve injury, a decrease in the expression of the K-Cl cotransporter KCC2, a major neuronal Cl(-) extruder, leads to pathologic alterations in GABA(A) and glycine receptor function in the spinal cord. T...

journal_title：Pain

authors： Asiedu M,Ossipov MH,Kaila K,Price TJ

更新日期：2010-02-01 00:00:00

abstract：:Clinical trials on the treatment of pain syndromes have adopted Patient Global Impression of Change (PGIC) as a primary outcome. However, little is known about how change in clinical status influences these ratings. The present study examined relationships between changes in pain, depressed mood, physical functioning,...

journal_title：Pain

authors： Geisser ME,Clauw DJ,Strand V,Gendreau MR,Palmer R,Williams DA

更新日期：2010-05-01 00:00:00

abstract：:Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...

journal_title：Pain

authors： Di Cesare Mannelli L,Cinci L,Micheli L,Zanardelli M,Pacini A,McIntosh JM,Ghelardini C

更新日期：2014-10-01 00:00:00

abstract：:The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...

journal_title：Pain

authors： Khandwala H,Hodge E,Loomis CW

更新日期：1997-09-01 00:00:00

abstract：:Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated excitability in sensory neurons. Nerve injury is also accompanied by increased expression of the extracellular matrix glycoprotein thrombospondin-4 (TSP4), and int...

journal_title：Pain

authors： Pan B,Guo Y,Wu HE,Park J,Trinh VN,Luo ZD,Hogan QH

更新日期：2016-09-01 00:00:00

abstract：:Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal cord neural network contributing to the development of CNP after spinal cord injury (SCI), we characterized the morphological and behavioral correlates of CNP in ...

journal_title：Pain

authors： Nees TA,Tappe-Theodor A,Sliwinski C,Motsch M,Rupp R,Kuner R,Weidner N,Blesch A

更新日期：2016-03-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:Diffuse burning dysesthetic sensations distal to the level of spinal injury are the most common and disabling painful sequelae of traumatic spinal cord injury (SCI). In a cross-sectional study of 19 SCI patients, clinical characteristics and results of 3 validated pain measurement instruments (McGill Pain Questionnair...

journal_title：Pain

authors： Davidoff G,Roth E,Guarracini M,Sliwa J,Yarkony G

更新日期：1987-04-01 00:00:00

abstract：:Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...

journal_title：Pain

authors： Berger RL,Byers MR,Calkins DF

更新日期：1983-04-01 00:00:00

abstract：:Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...

journal_title：Pain

authors： Beasley M,Freidin MB,Basu N,Williams FMK,Macfarlane GJ

更新日期：2019-02-01 00:00:00

abstract：:Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...

journal_title：Pain

authors： Chaturvedi SK

更新日期：1987-05-01 00:00:00

abstract：:Beneficial effects have been observed in University of Washington Pain Clinic patients treated with tricyclic antidepressants, but such effects occur much earlier than predicted mood elevation. A laboratory investigation of pain perception was employed to test the hypothesis that doxepin, a tricyclic antidepressant, h...

journal_title：Pain

authors： Chapman RC,Butler SH

更新日期：1978-10-01 00:00:00

abstract：:Noxious C-fibre stimulation produces increased sensitivity within the injured area (primary hyperalgesia), and a surrounding zone of secondary hyperalgesia. As significant changes in nociceptive processing occur during development, we compared C-fibre induced primary and secondary hyperalgesia in rat pups aged 3, 10 a...

journal_title：Pain

authors： Walker SM,Meredith-Middleton J,Lickiss T,Moss A,Fitzgerald M

更新日期：2007-03-01 00:00:00

abstract：:Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...

journal_title：Pain

authors： Egan KJ,Ready LB,Nessly M,Greer BE

更新日期：1992-04-01 00:00:00

abstract：:Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...

journal_title：Pain

authors： Xie JY,Qu C,Patwardhan A,Ossipov MH,Navratilova E,Becerra L,Borsook D,Porreca F

更新日期：2014-08-01 00:00:00

abstract：:The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....

journal_title：Pain

authors： Ohrbach R,Crow H,Kamer A

更新日期：1998-02-01 00:00:00

abstract：:Using the indirect immunofluorescence method, the distribution of cyclic GMP (cGMP) and nitric oxide synthase (NOS) was investigated in lumbar 5 dorsal root ganglia (DRGs) of untreated rats 1, 3 and 7 days following sciatic nerve section (axotomy). Untreated and axotomized (7 days) rats were also studied after perfusi...

journal_title：Pain

authors： Sten Shi TJ,Holmberg K,Xu ZD,Steinbusch H,de Vente J,Hökfelt T

更新日期：1998-12-01 00:00:00

abstract：:Low Back Pain Rating scale is an index scale which includes measurements of pain intensity, disability, and physical impairment. The scale was designed to monitor the outcome of clinical trials of low back pain treatment. It has been validated in 58 patients following first-time discectomy. The scale rating can be rap...

journal_title：Pain

authors： Manniche C,Asmussen K,Lauritsen B,Vinterberg H,Kreiner S,Jordan A

更新日期：1994-06-01 00:00:00

abstract：:Venoms peptides have produced exceptional sources for drug development to treat pain. In this study we examined the antinociceptive and side effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer venom, which inhibits high-voltage-dependent calcium channels (VDCC), preferentially P/Q and R-type VDCC. W...

journal_title：Pain

authors： Dalmolin GD,Silva CR,Rigo FK,Gomes GM,do Nascimento Cordeiro M,Richardson M,Silva MAR,Prado MAM,Gomez MV,Ferreira J

更新日期：2011-10-01 00:00:00

abstract：:The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...

journal_title：Pain

authors： Goossens ME,Vlaeyen JW,Rutten-van Mölken MP,van der Linden SM

更新日期：1999-03-01 00:00:00

abstract：:Psychologic assessment and treatment of the family of the chronic pain patient has been thought to be of benefit in the outcome of pain therapy. The present study was designed to determine the presence of psychologic symptoms in the spouses of pain patients and the relationship of distress levels between the marital p...

journal_title：Pain

authors： Shanfield SB,Heiman EM,Cope N,Jones JR

更新日期：1979-12-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00