Abstract:
:This study was designed to assess the role of calcitonin gene-related peptide (CGRP) and its receptor in the generation and maintenance of secondary mechanical allodynia and hyperalgesia induced by intradermal injection of capsaicin in rats. Paw withdrawal responses (PWRs) to von Frey hairs with different bending forces applied on the rat paw were tested in this study. CGRP(8-37), a specific antagonist of CGRP 1 receptors, was delivered through a microdialysis fiber inserted across the dorsal horn. Post- and pretreatment paradigms were followed. When CGRP(8-37) was administered 1h after capsaicin injection, the mechanical allodynia and hyperalgesia were partially reversed in a dose-dependent manner. On the other hand, when rats were treated with CGRP(8-37) prior to capsaicin injection, the PWRs to von Frey applications were significantly reduced as compared to control animals. Collectively, these results suggest that CGRP receptors present in the dorsal horn are involved in the generation and maintenance of nociceptive behaviors associated with cutaneous inflammation.
journal_name
Painjournal_title
Painauthors
Sun RQ,Lawand NB,Willis WDdoi
10.1016/s0304-3959(03)00008-3keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
201-8issue
1-2eissn
0304-3959issn
1872-6623pii
S0304395903000083journal_volume
104pub_type
杂志文章相关文献
PAIN文献大全abstract::Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00324-x
更新日期:2003-01-01 00:00:00
abstract::The investigation of neurotransmitter systems in placebo and nocebo effects has improved our understanding of these phenomena. Yet, most studies involve healthy participants. Because the pain modulatory system may differ in healthy participants and patients with chronic pain, it is important to investigate the evidenc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001682
更新日期:2020-01-01 00:00:00
abstract::Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001265
更新日期:2018-09-01 00:00:00
abstract::Using a number of complementary anatomical and molecular techniques, we studied the effects of chronic constriction injury (CCI), a model of partial nerve injury that elicits behavioral hyperalgesia, on primary sensory neurons in the rat. Dorsal root ganglia taken from animals with CCI were analyzed for alterations in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90189-9
更新日期:1994-07-01 00:00:00
abstract::Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000114
更新日期:2015-06-01 00:00:00
abstract::Altered pain sensitivity is believed to play an important role for chronification of headache. It has however mainly been evaluated in highly selected patients from headache clinics and never in longitudinal studies. The present study is a 12-year follow-up of a population-based study of primary headache disorders and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.10.023
更新日期:2008-07-31 00:00:00
abstract::Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and P...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00226-2
更新日期:2000-02-01 00:00:00
abstract::Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium channel subtype...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.015
更新日期:2014-10-01 00:00:00
abstract::Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90165-8
更新日期:1992-08-01 00:00:00
abstract::The relation between personality characteristics and the psychological functioning of headache patients has long been a topic of interest. Early investigations focused on clinical and anecdotal reports while recent research has moved toward a more objective evaluation of headache groups by using the MMPI. However, the...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(86)90037-0
更新日期:1986-02-01 00:00:00
abstract::In rats anaesthetised with Saffan (Glaxovet), inhibition of the tail flick reflex evoked by electrical stimulation in the dorsal periaqueductal grey matter (PAG) was accompanied by an increase in blood pressure, tachycardia, vasodilatation in hind limb muscle, an increase in respiration, pupillodilatation and widening...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90088-0
更新日期:1985-03-01 00:00:00
abstract::The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001764
更新日期:2020-04-01 00:00:00
abstract::In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90091-4
更新日期:1982-10-01 00:00:00
abstract::Recent studies demonstrate that some brain structures activated by pain are also engaged when an individual observes someone else in pain, and that these empathy-related responses are modulated as a function of the affective link between the empath and the individual in pain. In this study we test the hypothesis that ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.07.017
更新日期:2008-05-01 00:00:00
abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(99)00259-6
更新日期:2000-03-01 00:00:00
abstract::Expectations modulate the subjective experience of pain by increasing sensitivity to nociceptive inputs, an effect mediated by brain regions such as the insula. However, it is still unknown whether the neural structures underlying pain expectancy hold sensory-specific information or, alternatively, code for modality-i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001237
更新日期:2018-08-01 00:00:00
abstract::Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervent...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.07.006
更新日期:2010-10-01 00:00:00
abstract::This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.12.018
更新日期:2012-04-01 00:00:00
abstract::The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00169-F
更新日期:1995-05-01 00:00:00
abstract::The blood vessels and the pial surface of the brain, spinal cord and its roots are innervated by primary afferent neurones. Here, we have electrophysiologically characterized the functional properties of a subpopulation of these afferent fibres that supply the ventral roots of the cat sacral spinal cord. We have taken...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90167-V
更新日期:1991-04-01 00:00:00
abstract::OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000119
更新日期:2015-05-01 00:00:00
abstract::The present paper describes the pain reducing effect of high and low frequency transcutaneous electrical nerve stimulation (TENS) and 100 Hz mechanical vibratory stimulation as compared to placebo stimulation of the HoKu point in 50 patients suffering acute oro-facial pain. Ten of the 30 patients receiving actual stim...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(85)90100-9
更新日期:1985-11-01 00:00:00
abstract::The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1016/s0304-3959(96)03316-7
更新日期:1997-04-01 00:00:00
abstract::Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.10.025
更新日期:2013-02-01 00:00:00
abstract::The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(94)90053-1
更新日期:1994-10-01 00:00:00
abstract::Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in the neuroma model of neuropathic pain (HA rats (high autotomy) and LA ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.07.020
更新日期:2009-11-01 00:00:00
abstract::Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2006.09.032
更新日期:2007-05-01 00:00:00
abstract::Procedural pain is associated with poorer neurodevelopment in infants born very preterm (≤ 32 weeks gestational age), however, the etiology is unclear. Animal studies have demonstrated that early environmental stress leads to slower postnatal growth; however, it is unknown whether neonatal pain-related stress affects ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.007
更新日期:2012-07-01 00:00:00
abstract::A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(85)90010-7
更新日期:1985-12-01 00:00:00
abstract::Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90022-1
更新日期:1994-12-01 00:00:00