Abstract:
:Aiming at developing a new, noninvasive approach to spinal cord neuromodulation, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in the central pain pathways in human beings. A double-blind crossover design was used to investigate the effects of anodal direct current (2mA, 15min) applied on the skin overlying the thoracic spinal cord on the lower-limb flexion reflex in a group of 11 healthy volunteers. To investigate whether transcutaneous spinal cord DC stimulation (tsDCS) acts indirectly on the nociceptive reflex by modulating excitability in mono-oligosynaptic segmental reflex pathways, we also evaluated the H-reflex size from soleus muscle after tibial nerve stimulation. In our healthy subjects, anodal thoracic tsDCS reduced the total lower-limb flexion reflex area by 40.25% immediately after stimulation (T0) and by 46.9% 30min after stimulation offset (T30). When we analyzed the 2 lower-limb flexion reflex components (RII tactile and RIII nociceptive) separately, we found that anodal tsDCS induced a significant reduction in RIII area with a slight but not significant effect on RII area. After anodal tsDCS, the RIII area decreased by 27% at T0 and by 28% at T30. Both sham and active tsDCS left all the tested H-reflex variables unchanged. None of our subjects reported adverse effects after active stimulation. These results suggest that tsDCS holds promise as a tool that is complementary or alternative to drugs and invasive spinal cord electrical stimulation for managing pain. Thoracic transcutaneous direct current stimulation induces depression of nociceptive lower limb flexion reflex in human beings that persists after stimulation offset; this form of stimulation holds promise as a tool that is complementary or alternative to drugs and invasive spinal cord electrical stimulation for managing pain.
journal_name
Painjournal_title
Painauthors
Cogiamanian F,Vergari M,Schiaffi E,Marceglia S,Ardolino G,Barbieri S,Priori Adoi
10.1016/j.pain.2010.10.041subject
Has Abstractpub_date
2011-02-01 00:00:00pages
370-375issue
2eissn
0304-3959issn
1872-6623pii
00006396-201102000-00023journal_volume
152pub_type
杂志文章,随机对照试验相关文献
PAIN文献大全abstract::This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.02.030
更新日期:2011-06-01 00:00:00
abstract::Although trigeminal neuralgia and atypical facial pain can usually be distinguished on the basis of several well-established criteria, differential diagnosis is difficult in a small number of patients. The purpose of this study was to determine whether the McGill Pain Questionnaire (MPQ) is capable of discriminating b...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90157-0
更新日期:1986-12-01 00:00:00
abstract::Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait thr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001023
更新日期:2017-11-01 00:00:00
abstract::The purpose of this study was to develop and validate a measure of patient satisfaction for patients receiving treatment for either acute or chronic pain: the Pain Treatment Satisfaction Scale (PTSS). Development of the initial questionnaire included a comprehensive literature review and interviews with patients, phys...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.09.005
更新日期:2004-12-01 00:00:00
abstract::Salmon calcitonin (s-CT) has been shown to be a valuable analgesic in phantom limb pain (PLP) in several case reports. To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe P...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90127-W
更新日期:1992-01-01 00:00:00
abstract::Intramedullary or subarachnoid injections of alumina cream were made in the lumbar region of 38 adult cats. The animals were observed for 3 to 12 months and then subjected to acute neurophysiologic and histologic analysis. Neuronal hyperactivity in the dorsal horns was reliably produced by either subarachnoid or intra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90011-8
更新日期:1978-10-01 00:00:00
abstract::Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2013.04.005
更新日期:2013-08-01 00:00:00
abstract::Despite the presence of pathology in cancer pain, the pain experience in adult cancer patients cannot be totally explained by the extent of such pathology. Unlike chronic benign pain very little research on the role of biobehavioral factors has been conducted to help explain this paradox. The literature on the role of...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(88)90084-X
更新日期:1988-05-01 00:00:00
abstract::The present study is a long-term report on 69 patients undergoing unilateral percutaneous cervical cordotomy for vertebral pain due to neoplastic bone metastases. The pain was unilateral or bilateral and was characterised by a chronic and/or an incident component. Seventy-one per cent (49/69) of the patients benefitte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90832-7
更新日期:1984-06-01 00:00:00
abstract::Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/j.pain.2014.04.020
更新日期:2014-08-01 00:00:00
abstract::Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.01.056
更新日期:2011-06-01 00:00:00
abstract::The objective of this preliminary study was to examine the extent to which affective marital interaction related to depressive symptoms in persons with chronic pain and their spouses and to pain severity in persons with pain. Couples from the community completed self-report surveys and engaged in a videotaped conversa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.04.016
更新日期:2007-11-01 00:00:00
abstract::Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of a...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001322
更新日期:2018-11-01 00:00:00
abstract::The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90082-3
更新日期:1982-09-01 00:00:00
abstract::Extraterritorial spread of sensory symptoms is frequent in carpal tunnel syndrome (CTS). Animal models suggest that this phenomenon may depend on central sensitization. We sought to obtain psychophysical evidence of sensitization in CTS with extraterritorial symptoms spread. We recruited 100 unilateral CTS patients. A...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.10.025
更新日期:2010-02-01 00:00:00
abstract::Although both a loss of spinal inhibitory neurotransmission and the involvement of oxidative stress have been regarded as important mechanisms in the pathogenesis of pain, the relationship between these 2 mechanisms has not been studied. To determine whether reactive oxygen species (ROS) involvement in pain mechanisms...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.034
更新日期:2011-04-01 00:00:00
abstract::We investigated the effects of acute and of chronic morphine treatment on T-lymphocyte function and natural killer (NK) cell activity in rats receiving chronic constriction injury (CCI) of the sciatic nerve. T-Lymphocyte function was evaluated based on concanavalin-A (ConA)- and phytohemagglutinin (PHA)-induced spleno...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00323-7
更新日期:2000-11-01 00:00:00
abstract::The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00334-7
更新日期:2001-09-01 00:00:00
abstract::Visceral pain/discomfort is the cardinal complaints and treatment targets for functional gastrointestinal disorders (FGID). However, effective treatment for such pain is limited and often associated with high placebo effects. The mechanisms of placebo effects in visceral pain are unclear. We used functional neuroimagi...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2009.10.012
更新日期:2010-01-01 00:00:00
abstract::Our aim was to assess the discriminative capacity of the McGill Pain Questionnaire (MPQ) in patients with temporomandibular joint (TMJ) disorders or with myogenous facial pain (MP). The MPQ was administered to 57 TMJ and 28 MP patients who were also asked to assess the level of pain using the Visual Analog Scale (VAS)...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00461-9
更新日期:2001-04-01 00:00:00
abstract::In this study, construct validity of 2 pain behaviour observation measurement instruments for young children aged 1 to 56 months (mean age was 20 months) with burns is assessed by using Rasch analysis. The Rasch model, wherein data should meet the model expectations, assumes that an instrument measures one unidimensio...
journal_title:Pain
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.pain.2012.07.021
更新日期:2012-11-01 00:00:00
abstract::In this study, we examined the relationship between astrocyte activation in the cuneate nucleus (CN) and behavioral hypersensitivity after chronic constriction injury (CCI) of the median nerve. In addition, we also examined the effects of pre-emptive treatment with a number of drugs on astrocyte activation and hyperse...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.11.004
更新日期:2010-01-01 00:00:00
abstract::Pro-inflammatory cytokine production after nociceptive stimuli is pivotal for hyperalgesia. As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.11.011
更新日期:2010-02-01 00:00:00
abstract::Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00192-1
更新日期:1996-03-01 00:00:00
abstract::Interactions between the input from cutaneous and nociceptive muscle afferents in polysynaptic reflex pathways were investigated in man. Interaction was tested by evoking reflexes before, during, and after a period of muscle pain induced by intramuscular injection of hypertonic saline. Muscle pain was induced either i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00174-8
更新日期:2000-01-01 00:00:00
abstract::This work aimed to evaluate the potential role of the 5-HT(7) receptor in nociception secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands (5-HT(7) receptor agonists: AS-19, MSD-5a, E-55888; 5-HT(7) receptor antagonists: SB-258719, SB-269970; 5-HT(1A) receptor agonist: F-13640...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00226-1
更新日期:1998-04-01 00:00:00
abstract::Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Pos...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.10.023
更新日期:2009-01-01 00:00:00
abstract::Spinal synaptic plasticity is believed to drive central sensitization that underlies the persistent nature of neuropathic pain. Our recent data showed that synaptic plasticity in the dorsal horn is cell type specific: intense afferent stimulation produced long-term potentiation (LTP) in excitatory spinothalamic tract ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001014
更新日期:2017-11-01 00:00:00
abstract::We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(91)90109-B
更新日期:1991-09-01 00:00:00