Abstract：
:Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Possibly, the effects of single nucleotide polymorphisms (SNPs) vary depending on the pain task. The current investigation analyzed the association of five previously identified GCH1 SNPs with ratings of pain induced by topical high concentration (10%) capsaicin applied to the skin of 39 healthy human volunteers. Each of the GCH1 polymorphisms was associated with lower pain ratings. When combined, three of the five accounted for a surprisingly high 35% of the inter-individual variance in pain ratings. We conclude that SNPs of the GCH1 gene may profoundly affect the ratings of pain induced by capsaicin.
journal_name
Painjournal_title
Painauthors
Campbell CM,Edwards RR,Carmona C,Uhart M,Wand G,Carteret A,Kim YK,Frost J,Campbell JNdoi
10.1016/j.pain.2008.10.023subject
Has Abstractpub_date
2009-01-01 00:00:00pages
114-8issue
1-2eissn
0304-3959issn
1872-6623pii
S0304-3959(08)00671-4journal_volume
141pub_type
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