Comparing the DN4 tool with the IASP grading system for chronic neuropathic pain screening after breast tumor resection with and without paravertebral blocks: a prospective 6-month validation study.

Abstract:

:Investigating protective strategies against chronic neuropathic pain (CNP) after breast cancer surgery entails using valid screening tools. The DN4 (Douleur Neuropathique en 4 questions) is 1 tool that offers important research advantages. This prospective 6-month follow-up study seeks to validate the DN4 and assess its responsiveness in screening for CNP that satisfies the International Association for the Study of Pain (IASP) definition and fulfills its grading system criteria after breast tumor resection with and without paravertebral blocks (PVBs). We randomized 66 females to standardized general anesthesia and sham subcutaneous injections, or PVB and total intravenous anesthesia. The 6-month CNP risk was assessed using the IASP grading system and the DN4 screening tools. We evaluated the DN4 sensitivity, specificity, and responsiveness in capturing the impact of PVB on the CNP risk relative to the IASP grading system. Data from 64 patients showed similar demographic characteristics in both groups. Twenty patients in both groups met the grading system CNP criteria; among these, 18 patients also met the DN4 CNP criteria. Furthermore, 15 patients in both groups did not meet the grading system CNP criteria; among these, 9 patients also did not meet the DN4 CNP criteria. Therefore, the sensitivity and specificity of the DN4 were estimated at 90% and 60%, respectively. Both screening tools suggested that PVB reduced the 6-month CNP risk. Our results suggest that the DN4 can reliably identify CNP at 6 months after breast tumor resection and detect the preincisional PVB effect on the risk of developing such pain.

journal_name

Pain

journal_title

Pain

authors

Abdallah FW,Morgan PJ,Cil T,Escallon JM,Semple JL,Chan VW

doi

10.1097/j.pain.0000000000000108

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

740-749

issue

4

eissn

0304-3959

issn

1872-6623

pii

00006396-201504000-00021

journal_volume

156

pub_type

杂志文章,随机对照试验

相关文献

PAIN文献大全
  • Successful treatment of whiplash-type injury induced severe pain syndrome with epidural stimulation: a case report.

    abstract::Chronic severe cervico-facial pain syndrome associated with a whiplash-type injury was successfully treated with epidural spinal cord stimulation. The patient had been in pain for 9 years, responding temporarily only to stellate ganglion blocks. The patient has now been painless for 18 months. We have been unable to f...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(98)00218-8

    authors: Kirvelä OA,Kotilainen E

    更新日期:1999-03-01 00:00:00

  • Selective innervation of NK1 receptor-lacking lamina I spinoparabrachial neurons by presumed nonpeptidergic Aδ nociceptors in the rat.

    abstract::Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2014.08.023

    authors: Baseer N,Al-Baloushi AS,Watanabe M,Shehab SA,Todd AJ

    更新日期:2014-11-01 00:00:00

  • Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse.

    abstract::Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in somatosensory processing, as exemplified by the importance of spinal dynorphin-expressing neurons for the suppression of mechanical pain and chemical itch. Although it is...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001636

    authors: Serafin EK,Chamessian A,Li J,Zhang X,McGann A,Brewer CL,Berta T,Baccei M

    更新日期:2019-10-01 00:00:00

  • Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain.

    abstract::Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and noci...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000947

    authors: Ichihara K,Aizawa N,Akiyama Y,Kamei J,Masumori N,Andersson KE,Homma Y,Igawa Y

    更新日期:2017-08-01 00:00:00

  • The effects of feedback and contingent reinforcement on the exercise behavior of chronic pain patients.

    abstract::The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(92)90141-W

    authors: Geiger G,Todd DD,Clark HB,Miller RP,Kori SH

    更新日期:1992-05-01 00:00:00

  • Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine.

    abstract::A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression. Treatment was given, in randomized order, for periods of 4 weeks, separated by 1 week wash-o...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0304-3959(89)90108-5

    authors: Leijon G,Boivie J

    更新日期:1989-01-01 00:00:00

  • The role of threat-expectancy in acute pain: effects on attentional bias, coping strategy effectiveness and response to pain.

    abstract::The aims of this study were threefold. Firstly, to investigate the effect of increasing threat-expectancy on attentional biases towards pain-related words. Secondly, to determine the interaction between threat-expectancy and the effectiveness of two coping strategies on pain threshold and tolerance. Thirdly, to invest...

    journal_title:Pain

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.pain.2005.09.032

    authors: Boston A,Sharpe L

    更新日期:2005-12-15 00:00:00

  • Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices.

    abstract::Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(98)00113-4

    authors: Southall DM,Michael LR,Vasko RM

    更新日期:1998-10-01 00:00:00

  • The effects of myofascial trigger point injections are naloxone reversible.

    abstract::Ten patients with myofascial trigger point pain were entered into a double-blind cross-over study of the reversibility of myofascial trigger point injection (TPI) effects with naloxone versus placebo in order to test the hypothesis that the benefits of TPI are mediated, at least in part, through activation of an endog...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/0304-3959(88)90018-8

    authors: Fine PG,Milano R,Hare BD

    更新日期:1988-01-01 00:00:00

  • TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin.

    abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001848

    authors: Heber S,Ciotu CI,Hartner G,Gold-Binder M,Ninidze N,Gleiss A,Kress HG,Fischer MJM

    更新日期:2020-07-01 00:00:00

  • Heterotopic pruritic conditioning and itch--analogous to DNIC in pain?

    abstract::Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chron...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2010.02.026

    authors: van Laarhoven AIM,Kraaimaat FW,Wilder-Smith OH,van de Kerkhof PCM,Evers AWM

    更新日期:2010-05-01 00:00:00

  • Chronic pain and sensory changes after augmentation mammoplasty: long term effects of preincisional administration of methylprednisolone.

    abstract::We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.pain.2006.03.020

    authors: Romundstad L,Breivik H,Roald H,Skolleborg K,Romundstad PR,Stubhaug A

    更新日期:2006-09-01 00:00:00

  • Genetic factors influence the development of mechanical hypersensitivity, motor deficits and morphological damage after transient spinal cord ischemia in the rat.

    abstract::Genetic influence on the sensory, motor and histopathological outcome of transient spinal cord ischemia was studied in Sprague-Dawley (SD), spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Ischemia caused minor motor deficits and no identifiable morphological damage in the spinal cord of the majority of SD...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(93)90152-F

    authors: Wiesenfeld-Hallin Z,Hao JX,Xu XJ,Aldskogius H,Seiger Å

    更新日期:1993-11-01 00:00:00

  • Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats.

    abstract::The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(03)00115-5

    authors: Schäfers M,Sorkin LS,Sommer C

    更新日期:2003-08-01 00:00:00

  • Downregulation of adenosine and adenosine A1 receptor contributes to neuropathic pain in resiniferatoxin neuropathy.

    abstract::The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001246

    authors: Kan HW,Chang CH,Lin CL,Lee YC,Hsieh ST,Hsieh YL

    更新日期:2018-08-01 00:00:00

  • Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury.

    abstract::Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated excitability in sensory neurons. Nerve injury is also accompanied by increased expression of the extracellular matrix glycoprotein thrombospondin-4 (TSP4), and int...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000612

    authors: Pan B,Guo Y,Wu HE,Park J,Trinh VN,Luo ZD,Hogan QH

    更新日期:2016-09-01 00:00:00

  • Respiratory effects of epidural morphine and sufentanil in the absence and presence of chlordiazepoxide.

    abstract::The experiments determined the ventilatory effects of epidurally injected morphine and sufentanil in rats in the absence and in the presence of chlordiazepoxide, a drug that may alleviate the effects of stress. Soon after administration of morphine as well as of sufentanil, ventilation was more profoundly depressed wh...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(89)90159-0

    authors: Van den Hoogen RHWM,Bervoets KJW,Colpaert FC

    更新日期:1989-04-01 00:00:00

  • The influence of children's vocal expressions, age, medical diagnosis and information obtained from parents on nurses' pain assessments and decisions regarding interventions.

    abstract::This article reports on a study that examines the influence of task-related factors on nurses' pain assessments and decision regarding interventions. In an experimental design pediatric nurses (n = 202), were exposed to different cases, each case being a combination of a vignette and a videotape. For every case subjec...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(95)00147-6

    authors: Hamers JPH,Abu-Saad HH,van den Hout MA,Halfens RJG,Kester ADM

    更新日期:1996-04-01 00:00:00

  • Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion.

    abstract::We have developed a model in which inflammation contiguous to and within a dorsal root ganglion (DRG) was generated by local application of complete Freund's adjuvant (CFA) to the L4 lumbar spinal nerve as it exits from the intervertebral foramen. The periganglionic inflammation (PGI) elicited a marked reduction in wi...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2008.11.013

    authors: Amaya F,Samad TA,Barrett L,Broom DC,Woolf CJ

    更新日期:2009-03-01 00:00:00

  • The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.

    abstract::This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold)...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2009.12.002

    authors: da Costa DSM,Meotti FC,Andrade EL,Leal PC,Motta EM,Calixto JB

    更新日期:2010-03-01 00:00:00

  • One-year trend in pain and disability relief recall in acute and chronic ambulatory low back pain patients.

    abstract::Clinicians use patients' recall of pain and disability relief as indicators of therapeutic effectiveness. Recall can change over time, however, and is influenced by factors other than true relief, including current health status. We have determined the trend in the relative contribution of current pain/disability and ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(01)00377-3

    authors: Haas M,Nyiendo J,Aickin M

    更新日期:2002-01-01 00:00:00

  • Lack of analgesic effect of 50 and 100 mg oral tramadol after orthopaedic surgery: a randomized, double-blind, placebo and standard active drug comparison.

    abstract::Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now availabl...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0304-3959(95)00056-X

    authors: Stubhaug A,Grimstad J,Breivik H

    更新日期:1995-07-01 00:00:00

  • A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy.

    abstract::Current treatments for post-injury movement-evoked pain are inadequate. Non-opioids may complement opioids, which preferentially reduce spontaneous pain, but most have incomplete efficacy as single agents. This trial evaluates efficacy of a gabapentin-rofecoxib combination following hysterectomy. In addition to IV-PCA...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.pain.2004.10.008

    authors: Gilron I,Orr E,Tu D,O'Neill JP,Zamora JE,Bell AC

    更新日期:2005-01-01 00:00:00

  • Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome.

    abstract::Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2011.06.012

    authors: Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

    更新日期:2011-12-01 00:00:00

  • Pain catastrophizing is related to temporal summation of pain but not temporal summation of the nociceptive flexion reflex.

    abstract::Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2010.12.041

    authors: Rhudy JL,Martin SL,Terry EL,France CR,Bartley EJ,DelVentura JL,Kerr KL

    更新日期:2011-04-01 00:00:00

  • Gender differences in pain and depressive tendency among Chinese elders with knee osteoarthritis.

    abstract::The purpose of this study was to explore gender differences in pain experiences, pain control beliefs, pain coping strategies, and depressive tendency among Chinese elderly with knee osteoarthritis (OA). Participants (N=199) were drawn from a previous convenience sample of outpatients with OA in Taiwan. Results indica...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2007.03.014

    authors: Tsai YF

    更新日期:2007-07-01 00:00:00

  • Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.

    abstract::Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits ne...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001738

    authors: Wu M,Li Z,Liang L,Ma P,Cui D,Chen P,Wu G,Song XJ

    更新日期:2020-03-01 00:00:00

  • Altered experimental pain perception after cerebellar infarction.

    abstract::Animal studies have suggested that the cerebellum, in addition to its motor functions, also has a role in pain processing and modulation, possibly because of its extensive connections with the prefrontal cortex and with brainstem regions involved in descending pain control. Consistently, human imaging studies have sho...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2014.04.006

    authors: Ruscheweyh R,Kühnel M,Filippopulos F,Blum B,Eggert T,Straube A

    更新日期:2014-07-01 00:00:00

  • Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain.

    abstract::Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mechanisms. As part of the Veterans Integrated Pain Evaluation Rese...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000728

    authors: Chamessian A,Van de Ven T,Buchheit T,Hsia HL,McDuffie M,Gamazon ER,Walsh C,Bruehl S,Buckenmaier C' 3rd,Shaw A

    更新日期:2017-01-01 00:00:00

  • Response properties of nociceptive and non-nociceptive neurons in the rat's trigeminal subnucleus caudalis (medullary dorsal horn) related to cutaneous and deep craniofacial afferent stimulation and modulation by diffuse noxious inhibitory controls.

    abstract::An electrophysiological study was carried out in anesthetized rats to characterize the properties of single neurons in trigeminal (V) subnucleus caudalis. Each neuron was functionally classified in terms of its cutaneous mechanoreceptive field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(90)90010-B

    authors: Hu JW

    更新日期:1990-06-01 00:00:00